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DDX19B DEAD-box helicase 19B [ Homo sapiens (human) ]

Gene ID: 11269, updated on 5-Aug-2018

Summary

Official Symbol
DDX19Bprovided by HGNC
Official Full Name
DEAD-box helicase 19Bprovided by HGNC
Primary source
HGNC:HGNC:2742
See related
Ensembl:ENSG00000157349 MIM:605812; Vega:OTTHUMG00000137577
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DBP5; RNAh; DDX19
Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which exhibits RNA-dependent ATPase and ATP-dependent RNA-unwinding activities. This protein is recruited to the cytoplasmic fibrils of the nuclear pore complex, where it participates in the export of mRNA from the nucleus. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 16.5), thyroid (RPKM 10.7) and 25 other tissues See more
Orthologs

Genomic context

See DDX19B in Genome Data Viewer
Location:
16q22.1
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (70289767..70335213)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (70323670..70367735)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene exosome component 6 Neighboring gene alanyl-tRNA synthetase Neighboring gene RNA, 7SL, cytoplasmic 279, pseudogene Neighboring gene uncharacterized LOC100506083 Neighboring gene DEAD-box helicase 19A Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
helicase activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
mRNA export from nucleus TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
membrane HDA PubMed 
nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear pore IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ATP-dependent RNA helicase DDX19B
Names
ATP-dependent RNA helicase DDX19
DEAD (Asp-Glu-Ala-As) box polypeptide 19B
DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B
DEAD box protein 19B
DEAD-box RNA helicase DEAD5
DEAD-box protein 5
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 19 (Dbp5, yeast, homolog)
yeast Dbp5 homolog
NP_001014449.1
NP_001014451.1
NP_001244101.1
NP_001244102.1
NP_001244103.1
NP_001244104.1
NP_009173.1
XP_006721190.1
XP_011521134.1
XP_011521135.1
XP_011521136.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014449.3NP_001014449.1  ATP-dependent RNA helicase DDX19B isoform 3

    See identical proteins and their annotated locations for NP_001014449.1

    Status: REVIEWED

    Source sequence(s)
    AC012184, BC003626, BC010008, BI756088, DC385044
    Consensus CDS
    CCDS42187.1
    UniProtKB/Swiss-Prot
    Q9UMR2
    UniProtKB/TrEMBL
    A0A024QZ90
    Related
    ENSP00000377267.2, OTTHUMP00000255698, ENST00000393657.6
    Conserved Domains (1) summary
    COG0513
    Location:1369
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
  2. NM_001014451.3NP_001014451.1  ATP-dependent RNA helicase DDX19B isoform 2

    See identical proteins and their annotated locations for NP_001014451.1

    Status: REVIEWED

    Source sequence(s)
    AC012184, AL136639, BC003626, BI756088, DC385044
    Consensus CDS
    CCDS32475.1
    UniProtKB/Swiss-Prot
    Q9UMR2
    Related
    ENSP00000348271.3, OTTHUMP00000255699, ENST00000355992.7
    Conserved Domains (1) summary
    COG0513
    Location:101447
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
  3. NM_001257172.2NP_001244101.1  ATP-dependent RNA helicase DDX19B isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC012184, AK302107
    Consensus CDS
    CCDS58478.1
    UniProtKB/Swiss-Prot
    Q9UMR2
    Related
    ENSP00000392639.3, OTTHUMP00000255694, ENST00000451014.7
    Conserved Domains (3) summary
    COG0513
    Location:106452
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd00079
    Location:281416
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cl21455
    Location:105270
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. NM_001257173.2NP_001244102.1  ATP-dependent RNA helicase DDX19B isoform 3

    See identical proteins and their annotated locations for NP_001244102.1

    Status: REVIEWED

    Source sequence(s)
    AC012184, AK301938
    Consensus CDS
    CCDS42187.1
    UniProtKB/Swiss-Prot
    Q9UMR2
    UniProtKB/TrEMBL
    A0A024QZ90
    Related
    ENSP00000456757.1, OTTHUMP00000255696, ENST00000568625.5
    Conserved Domains (1) summary
    COG0513
    Location:1369
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
  5. NM_001257174.2NP_001244103.1  ATP-dependent RNA helicase DDX19B isoform 3

    See identical proteins and their annotated locations for NP_001244103.1

    Status: REVIEWED

    Source sequence(s)
    AC012184, AF353720
    Consensus CDS
    CCDS42187.1
    UniProtKB/Swiss-Prot
    Q9UMR2
    UniProtKB/TrEMBL
    A0A024QZ90
    Related
    ENSP00000456574.1, OTTHUMP00000255745, ENST00000563392.5
    Conserved Domains (1) summary
    COG0513
    Location:1369
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
  6. NM_001257175.2NP_001244104.1  ATP-dependent RNA helicase DDX19B isoform 5

    See identical proteins and their annotated locations for NP_001244104.1

    Status: REVIEWED

    Source sequence(s)
    AC012184, AK296868, DC385044
    UniProtKB/TrEMBL
    B4DL69
    Conserved Domains (1) summary
    COG0513
    Location:9327
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
  7. NM_001363938.1NP_001350867.1  ATP-dependent RNA helicase DDX19B isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC012184
    Consensus CDS
    CCDS86540.1
    Conserved Domains (1) summary
    COG0513
    Location:95483
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
  8. NM_007242.6NP_009173.1  ATP-dependent RNA helicase DDX19B isoform 1

    See identical proteins and their annotated locations for NP_009173.1

    Status: REVIEWED

    Source sequence(s)
    AC012184, BC003626, BI756088, DC385044
    Consensus CDS
    CCDS10888.1
    UniProtKB/Swiss-Prot
    Q9UMR2
    UniProtKB/TrEMBL
    A0A0U4B4U6
    Related
    ENSP00000288071.6, OTTHUMP00000174901, ENST00000288071.10
    Conserved Domains (1) summary
    COG0513
    Location:90478
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    70289767..70335213
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522834.2XP_011521136.1  ATP-dependent RNA helicase DDX19B isoform X3

    UniProtKB/TrEMBL
    H3BQK0
    Related
    ENSP00000455813.1, OTTHUMP00000255695, ENST00000563206.5, OTTHUMT00000435032
    Conserved Domains (1) summary
    COG0513
    Location:95483
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
  2. XM_011522832.2XP_011521134.1  ATP-dependent RNA helicase DDX19B isoform X1

    Conserved Domains (3) summary
    PTZ00424
    Location:151529
    PTZ00424; helicase 45; Provisional
    cd00079
    Location:367502
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cl21455
    Location:154356
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. XM_011522833.2XP_011521135.1  ATP-dependent RNA helicase DDX19B isoform X2

    Conserved Domains (3) summary
    COG0513
    Location:161507
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd00079
    Location:336471
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cl21455
    Location:160325
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. XM_006721127.2XP_006721190.1  ATP-dependent RNA helicase DDX19B isoform X4

    See identical proteins and their annotated locations for XP_006721190.1

    UniProtKB/Swiss-Prot
    Q9UMR2
    UniProtKB/TrEMBL
    A0A024QZ90
    Conserved Domains (1) summary
    COG0513
    Location:1369
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
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