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CHP1 calcineurin like EF-hand protein 1 [ Homo sapiens (human) ]

Gene ID: 11261, updated on 9-Dec-2018

Summary

Official Symbol
CHP1provided by HGNC
Official Full Name
calcineurin like EF-hand protein 1provided by HGNC
Primary source
HGNC:HGNC:17433
See related
Ensembl:ENSG00000187446 MIM:606988
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CHP; p22; p24; Sid470p; SLC9A1BP
Summary
This gene encodes a phosphoprotein that binds to the Na+/H+ exchanger NHE1. This protein serves as an essential cofactor which supports the physiological activity of NHE family members and may play a role in the mitogenic regulation of NHE1. The protein shares similarity with calcineurin B and calmodulin and it is also known to be an endogenous inhibitor of calcineurin activity. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in colon (RPKM 59.2), liver (RPKM 56.3) and 25 other tissues See more
Orthologs

Genomic context

See CHP1 in Genome Data Viewer
Location:
15q15.1
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (41231156..41281887)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (41523341..41574085)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 92, member A2 (pseudogene) Neighboring gene RNA, 7SL, cytoplasmic 497, pseudogene Neighboring gene exonuclease 3'-5' domain containing 1 Neighboring gene OIP5 antisense RNA 1 Neighboring gene Opa interacting protein 5 Neighboring gene nucleolar and spindle associated protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

Pathways from BioSystems

  • Alzheimers Disease, organism-specific biosystem (from WikiPathways)
    Alzheimers Disease, organism-specific biosystemThis pathway displays current genes, proteolytic events and other processes associated with the progression of Alzheimer's disease. This pathway was adapted from KEGG on 10/7/2011. Note: mitochondria...
  • Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem (from Pathway Interaction Database)
    Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem
    Calcium signaling in the CD4+ TCR pathway
  • Glycosaminoglycan metabolism, organism-specific biosystem (from REACTOME)
    Glycosaminoglycan metabolism, organism-specific biosystemGlycosaminoglycans (GAGs) are long, unbranched polysaccharides containing a repeating disaccharide unit composed of a hexosamine (either N-acetylgalactosamine (GalNAc) or N-acetylglucosamine (GlcNAc)...
  • Hyaluronan metabolism, organism-specific biosystem (from REACTOME)
    Hyaluronan metabolism, organism-specific biosystemHyaluronan (hyaluronic acid, hyaluronate or HA) is an anionic glycosaminoglycan (GAG) distributed widely throughout connective, epithelial, and neural tissues and most abundant in the extracellular m...
  • Hyaluronan uptake and degradation, organism-specific biosystem (from REACTOME)
    Hyaluronan uptake and degradation, organism-specific biosystemHyaluronan (HA) turnover can occur locally at the tissue of origin, where it is taken up by cells to be degraded, or released into the lymphatic and vascular systems, where it can be eliminated by th...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of carbohydrates, organism-specific biosystem (from REACTOME)
    Metabolism of carbohydrates, organism-specific biosystemThese pathways together are responsible for: 1) the extraction of energy and carbon skeletons for biosyntheses from dietary sugars and related molecules; 2) the short-term storage of glucose in the b...
  • Role of Calcineurin-dependent NFAT signaling in lymphocytes, organism-specific biosystem (from Pathway Interaction Database)
    Role of Calcineurin-dependent NFAT signaling in lymphocytes, organism-specific biosystem
    Role of Calcineurin-dependent NFAT signaling in lymphocytes
  • T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection, organism-specific biosystem (from WikiPathways)
    T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection, organism-specific biosystemThis pathway is based on Figure 4 of "A Model of an Integrated Immune System Pathway in Homo sapiens and Its Interaction with Superantigen Producing Expression Regulatory Pathway in Staphylococcus au...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20350

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium-dependent protein binding IDA
Inferred from Direct Assay
more info
PubMed 
kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
 
potassium channel regulator activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
calcium ion regulated exocytosis IEA
Inferred from Electronic Annotation
more info
 
cellular response to acidic pH ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasmic microtubule organization ISS
Inferred from Sequence or Structural Similarity
more info
 
hyaluronan catabolic process TAS
Traceable Author Statement
more info
 
membrane docking ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane fusion ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane organization ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule bundle formation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of calcineurin-NFAT signaling cascade IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein targeting to membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein transport ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of sodium:proton antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of sodium:proton antiporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
potassium ion transport TAS
Traceable Author Statement
more info
PubMed 
protein complex oligomerization IEA
Inferred from Electronic Annotation
more info
 
protein export from nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of intracellular pH IDA
Inferred from Direct Assay
more info
PubMed 
regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum-Golgi intermediate compartment IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
focal adhesion HDA PubMed 
microtubule cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
transport vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
calcineurin B homologous protein 1
Names
EF-hand calcium-binding domain-containing protein p22
SLC9A1 binding protein
calcineurin B homolog
calcineurin B-like protein
calcineurin homologous protein
calcium binding protein P22
calcium-binding protein CHP
calcium-binding protein p22

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007236.5NP_009167.1  calcineurin B homologous protein 1

    See identical proteins and their annotated locations for NP_009167.1

    Status: REVIEWED

    Source sequence(s)
    AC012652
    Consensus CDS
    CCDS10073.1
    UniProtKB/Swiss-Prot
    Q99653
    UniProtKB/TrEMBL
    A0A024R9M9
    Related
    ENSP00000335632.5, ENST00000334660.9
    Conserved Domains (1) summary
    COG5126
    Location:1182
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

    Range
    41231156..41281887
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021879.2XP_016877368.1  calcineurin B homologous protein 1 isoform X1

    UniProtKB/TrEMBL
    H0YKE7
    Related
    ENSP00000452772.1, ENST00000560784.5
    Conserved Domains (1) summary
    cl25352
    Location:198
    EFh_PEF; The penta-EF hand (PEF) family
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