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ERI2 ERI1 exoribonuclease family member 2 [ Homo sapiens (human) ]

Gene ID: 112479, updated on 11-Jun-2021

Summary

Official Symbol
ERI2provided by HGNC
Official Full Name
ERI1 exoribonuclease family member 2provided by HGNC
Primary source
HGNC:HGNC:30541
See related
Ensembl:ENSG00000196678
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EXOD1; ZGRF5
Expression
Ubiquitous expression in testis (RPKM 7.3), liver (RPKM 6.6) and 25 other tissues See more
Orthologs
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Genomic context

See ERI2 in Genome Data Viewer
Location:
16p12.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (20780193..20806472, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (20791515..20817794, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene acyl-CoA synthetase medium chain family member 1 Neighboring gene uncharacterized LOC105379461 Neighboring gene acyl-CoA synthetase medium chain family member 4 pseudogene Neighboring gene THUMP domain containing 1 Neighboring gene acyl-CoA synthetase medium chain family member 3 Neighboring gene RNA, U6 small nuclear 944, pseudogene Neighboring gene uncharacterized LOC105371121 Neighboring gene RNA exonuclease 5 Neighboring gene defective in cullin neddylation 1 domain containing 3 Neighboring gene LYR motif containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ERI1 exoribonuclease family member 2 (ERI2) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1504, MGC16943

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3'-5'-exoribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ERI1 exoribonuclease 2
Names
enhanced RNAi three prime mRNA exonuclease homolog 2
exonuclease domain containing 1
exonuclease domain-containing protein 1
exoribonuclease 2
zinc finger, GRF-type containing 5
NP_001136197.1
NP_542394.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142725.2NP_001136197.1  ERI1 exoribonuclease 2 isoform 1

    See identical proteins and their annotated locations for NP_001136197.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK292594, BC010503, BX648185
    Consensus CDS
    CCDS45436.1
    UniProtKB/Swiss-Prot
    A8K979
    Related
    ENSP00000350651.4, ENST00000357967.9
    Conserved Domains (2) summary
    cd06133
    Location:37230
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    pfam06839
    Location:595643
    zf-GRF; GRF zinc finger
  2. NM_080663.3NP_542394.2  ERI1 exoribonuclease 2 isoform 2

    See identical proteins and their annotated locations for NP_542394.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and has multiple differences in the 3' coding region, compared to variant 1. These differences result in a protein (isoform 2) with a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK292594, BC010503, BX437401
    Consensus CDS
    CCDS10590.1
    UniProtKB/Swiss-Prot
    A8K979
    Related
    ENSP00000300005.3, ENST00000300005.7
    Conserved Domains (1) summary
    cd06133
    Location:37230
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    20780193..20806472 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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