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DCUN1D3 defective in cullin neddylation 1 domain containing 3 [ Homo sapiens (human) ]

Gene ID: 123879, updated on 1-Jun-2020

Summary

Official Symbol
DCUN1D3provided by HGNC
Official Full Name
defective in cullin neddylation 1 domain containing 3provided by HGNC
Primary source
HGNC:HGNC:28734
See related
Ensembl:ENSG00000188215 MIM:616167
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
44M2.4; SCCRO3
Expression
Ubiquitous expression in fat (RPKM 6.0), gall bladder (RPKM 5.4) and 25 other tissues See more
Orthologs

Genomic context

See DCUN1D3 in Genome Data Viewer
Location:
16p12.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (20854925..20900358, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (20866219..20911561, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene acyl-CoA synthetase medium chain family member 3 Neighboring gene RNA, U6 small nuclear 944, pseudogene Neighboring gene ERI1 exoribonuclease family member 2 Neighboring gene uncharacterized LOC105371121 Neighboring gene RNA exonuclease 5 Neighboring gene LYR motif containing 1 Neighboring gene dynein axonemal heavy chain 3 Neighboring gene uncharacterized LOC107984888 Neighboring gene Sharpr-MPRA regulatory region 1818

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41725, MGC48972, DKFZp686O0290, DKFZp686G23203

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cullin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-like protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
negative regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein neddylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to UV-C IDA
Inferred from Direct Assay
more info
PubMed 
response to gamma radiation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
DCN1-like protein 3
Names
DCN1, defective in cullin neddylation 1, domain containing 3
DCUN1 domain-containing protein 3
defective in cullin neddylation protein 1-like protein 3
squamous cell carcinoma-related oncogene 3
NP_775746.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173475.4NP_775746.1  DCN1-like protein 3

    See identical proteins and their annotated locations for NP_775746.1

    Status: VALIDATED

    Source sequence(s)
    AC002394, AC004381, AK027199, BC040442, DA545688
    Consensus CDS
    CCDS10592.1
    UniProtKB/Swiss-Prot
    Q8IWE4
    Related
    ENSP00000319482.3, ENST00000324344.9
    Conserved Domains (1) summary
    pfam03556
    Location:161276
    Cullin_binding; Cullin binding

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    20854925..20900358 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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