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CHN2 chimerin 2 [ Homo sapiens (human) ]

Gene ID: 1124, updated on 5-Aug-2018

Summary

Official Symbol
CHN2provided by HGNC
Official Full Name
chimerin 2provided by HGNC
Primary source
HGNC:HGNC:1944
See related
Ensembl:ENSG00000106069 Ensembl:ENSG00000285162 MIM:602857; Vega:OTTHUMG00000023063
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BCH; CHN2-3; ARHGAP3; RHOGAP3
Summary
This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that contains a phorbol-ester/diacylglycerol (DAG)-type zinc finger, a Rho-GAP domain, and an SH2 domain. The encoded protein translocates from the cytosol to the Golgi apparatus membrane upon binding by diacylglycerol (DAG). Activity of this protein is important in cell proliferation and migration, and expression changes in this gene have been detected in cancers. A mutation in this gene has also been associated with schizophrenia in men. Alternative transcript splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, May 2014]
Expression
Broad expression in duodenum (RPKM 21.4), small intestine (RPKM 16.7) and 20 other tissues See more
Orthologs

Genomic context

See CHN2 in Genome Data Viewer
Location:
7p14.3
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (29146547..29514335)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (29233991..29553944)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene carboxypeptidase, vitellogenic like Neighboring gene uncharacterized LOC107986703 Neighboring gene uncharacterized LOC101928168 Neighboring gene uncharacterized LOC102724484 Neighboring gene Nanog homeobox pseudogene 4 Neighboring gene uncharacterized LOC107986700 Neighboring gene general transcription factor IIIC subunit 6 pseudogene Neighboring gene proline rich 15

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of atypical psychosis.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Pathways from BioSystems

  • ErbB1 downstream signaling, organism-specific biosystem (from Pathway Interaction Database)
    ErbB1 downstream signaling, organism-specific biosystem
    ErbB1 downstream signaling
  • Regulation of RAC1 activity, organism-specific biosystem (from Pathway Interaction Database)
    Regulation of RAC1 activity, organism-specific biosystem
    Regulation of RAC1 activity
  • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
    Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138360

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity TAS
Traceable Author Statement
more info
 
SH3/SH2 adaptor activity TAS
Traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
beta-chimaerin
Names
beta-chimerin
beta3-chimaerin
chimerin (chimaerin) 2
chimerin, beta-2
chimerin, testis-specific
rho-GTPase-activating protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029365.2 RefSeqGene

    Range
    52959..372789
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001039936.2NP_001035025.1  beta-chimaerin isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform (1).
    Source sequence(s)
    AC007255, AK026415, BC112155, BU743119
    Consensus CDS
    CCDS47566.1
    UniProtKB/Swiss-Prot
    P52757
    Related
    ENSP00000486515.1, OTTHUMP00000279221, ENST00000412711.6, OTTHUMT00000327536
    Conserved Domains (2) summary
    cd04372
    Location:139332
    RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...
    pfam00130
    Location:79131
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  2. NM_001293069.1NP_001279998.1  beta-chimaerin isoform 3

    See identical proteins and their annotated locations for NP_001279998.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and contains multiple additional 5' coding exons, compared to variant 1. It represents use of an alternate promoter and initiates translation from an alternate start codon. The encoded isoform (3) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AC004417, AC007255, AK294271, BU743119, DA190643
    Consensus CDS
    CCDS87488.1
    UniProtKB/Swiss-Prot
    P52757
    UniProtKB/TrEMBL
    B7Z232
    Related
    ENSP00000495614.1, ENST00000644824.1
    Conserved Domains (3) summary
    cd10352
    Location:127213
    SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
    cd04372
    Location:350543
    RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...
    pfam00130
    Location:290342
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  3. NM_001293070.1NP_001279999.1  beta-chimaerin isoform 4

    See identical proteins and their annotated locations for NP_001279999.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and contains multiple additional 5' coding exons, compared to variant 1. It represents use of an alternate promoter and initiates translation from an alternate start codon. The encoded isoform (4) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AC004593, AC007255, AK293959, BC112155, BU743119, DA105459
    UniProtKB/Swiss-Prot
    P52757
    UniProtKB/TrEMBL
    B7Z1V0
    Conserved Domains (3) summary
    cd10352
    Location:65151
    SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
    cd04372
    Location:288481
    RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...
    pfam00130
    Location:228280
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  4. NM_001293071.1NP_001280000.1  beta-chimaerin isoform 5

    See identical proteins and their annotated locations for NP_001280000.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5, also known as B2-CHNdel ex3) differs in the 5' UTR and and contains multiple additional 5' coding exons, compared to variant 1. It represents use of an alternate promoter and initiates translation from an alternate start codon. The encoded isoform (5) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AC004593, AC007255, BC112155, BU743119, DA105459, EU732760
    UniProtKB/Swiss-Prot
    P52757
    UniProtKB/TrEMBL
    B3VCF9
    Conserved Domains (3) summary
    cd10352
    Location:17103
    SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
    cd04372
    Location:240433
    RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...
    pfam00130
    Location:180232
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  5. NM_001293072.1NP_001280001.1  beta-chimaerin isoform 6

    See identical proteins and their annotated locations for NP_001280001.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and contains multiple additional 5' coding exons, compared to variant 1. It represents use of an alternate promoter and initiates translation from an alternate start codon. The encoded isoform (6) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AC007255, AK294032, BU743119
    UniProtKB/TrEMBL
    B7Z1W9
    Conserved Domains (3) summary
    cd10352
    Location:37123
    SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
    cd04372
    Location:260453
    RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...
    pfam00130
    Location:200252
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  6. NM_001293073.1NP_001280002.1  beta-chimaerin isoform 7

    See identical proteins and their annotated locations for NP_001280002.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7, also known as B1-CHNdel ex7p) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (7) is shorter than isoform 1.
    Source sequence(s)
    AC007255, AK026415, BC112155, BU743119, EU732752
    UniProtKB/Swiss-Prot
    P52757
    Conserved Domains (2) summary
    cd04372
    Location:94287
    RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...
    pfam00130
    Location:3786
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  7. NM_001293075.1NP_001280004.1  beta-chimaerin isoform 8

    See identical proteins and their annotated locations for NP_001280004.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8, also known as B1-CHNdel ex7p,11) uses an alternate in-frame splice site in the 5' coding region and lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (8) is shorter than isoform 1.
    Source sequence(s)
    AC007255, AK026415, BC112155, BU743119, EU732753
    UniProtKB/Swiss-Prot
    P52757
    Conserved Domains (2) summary
    pfam00130
    Location:3786
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl02570
    Location:94241
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
  8. NM_001293076.1NP_001280005.1  beta-chimaerin isoform 9

    See identical proteins and their annotated locations for NP_001280005.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9, also known as B1-CHNdel ex9) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (9) is shorter than isoform 1.
    Source sequence(s)
    AC007255, AK026415, BC112155, BU743119, EU732754
    Consensus CDS
    CCDS78219.1
    UniProtKB/Swiss-Prot
    P52757
    Related
    ENSP00000394284.2, ENST00000421775.6
    Conserved Domains (2) summary
    pfam00130
    Location:79110
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl02570
    Location:107274
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
  9. NM_001293077.1NP_001280006.1  beta-chimaerin isoform 10

    See identical proteins and their annotated locations for NP_001280006.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10, also known as B1-CHNdel ex10-11) lacks two alternate in-frame exons, compared to variant 1. The encoded isoform (10) is shorter than isoform 1.
    Source sequence(s)
    AC007255, AK026415, BC112155, BU743119, EU732756
    Consensus CDS
    CCDS78218.1
    UniProtKB/Swiss-Prot
    P52757
    UniProtKB/TrEMBL
    B3VCF5
    Related
    ENSP00000386849.5, ENST00000409041.7
    Conserved Domains (2) summary
    pfam00130
    Location:79131
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl02570
    Location:139260
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
  10. NM_001293078.1NP_001280007.1  beta-chimaerin isoform 11

    See identical proteins and their annotated locations for NP_001280007.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11, also known as B1-CHNdel ex9,11) lacks two alternate in-frame exons, compared to variant 1. The encoded isoform (11) is shorter than isoform 1.
    Source sequence(s)
    AC007255, AK026415, BC112155, BU743119, EU732755
    Consensus CDS
    CCDS78220.1
    UniProtKB/Swiss-Prot
    P52757
    UniProtKB/TrEMBL
    B3VCF4
    Related
    ENSP00000406337.3, ENST00000424025.4
    Conserved Domains (2) summary
    pfam00130
    Location:79110
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl02570
    Location:107228
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
  11. NM_001293079.1NP_001280008.1  beta-chimaerin isoform 12

    See identical proteins and their annotated locations for NP_001280008.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12, also known as B1-CHNdel ex11-12) lacks two alternate exons in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (12) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC007255, AK026415, BC112155, BU743119, EU732757
    Consensus CDS
    CCDS78217.1
    UniProtKB/Swiss-Prot
    P52757
    UniProtKB/TrEMBL
    B3VCF6
    Related
    ENSP00000387425.3, ENST00000439711.6
    Conserved Domains (2) summary
    pfam00130
    Location:79131
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl02570
    Location:139194
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
  12. NM_001293080.1NP_001280009.1  beta-chimaerin isoform 13

    See identical proteins and their annotated locations for NP_001280009.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13, also known as B1-CHNdel ex11) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (13) is shorter than isoform 1.
    Source sequence(s)
    AC007255, AK026415, BC112155, BU743119, EU732758
    UniProtKB/Swiss-Prot
    P52757
    Conserved Domains (2) summary
    pfam00130
    Location:79131
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl02570
    Location:139286
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
  13. NM_001293081.1NP_001280010.1  beta-chimaerin isoform 14

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (14) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC007255, AK294216, BU743119
    UniProtKB/TrEMBL
    B7Z215
    Conserved Domains (2) summary
    cd04372
    Location:68261
    RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...
    pfam00130
    Location:1260
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  14. NM_004067.3NP_004058.1  beta-chimaerin isoform 2

    See identical proteins and their annotated locations for NP_004058.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and contains multiple additional 5' coding exons, compared to variant 1. It represents use of an alternate promoter and initiates translation from an alternate start codon. The encoded isoform (2) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AC004593, AC007255, BC112155, BU743119, DA105459
    Consensus CDS
    CCDS5420.1
    UniProtKB/Swiss-Prot
    P52757
    Related
    ENSP00000222792.6, OTTHUMP00000122624, ENST00000222792.10, OTTHUMT00000214228
    Conserved Domains (3) summary
    cd10352
    Location:52138
    SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
    cd04372
    Location:275468
    RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...
    pfam00130
    Location:215267
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RNA

  1. NR_120524.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15, also known as B1-CHNdel ex7p-8,11-12) uses an alternate splice site at the 5' terminal exon and lacks three alternate internal exons, compared to variant 1. This variant is represented as non-coding because the longest in-frame ORF does not meet RefSeq quality criteria.
    Source sequence(s)
    AC007255, AK026415, BC112155, BU743119, EU732750
  2. NR_120525.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16, also known as B1-CHNdel ex7p-9) uses an alternate splice site at the 5' terminal exon and lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the longest in-frame ORF does not meet RefSeq quality criteria.
    Source sequence(s)
    AC007255, AK026415, BC112155, BU743119, EU732751

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    29146547..29514335
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011721.1XP_016867210.1  beta-chimaerin isoform X1

  2. XM_011515105.2XP_011513407.1  beta-chimaerin isoform X2

    Conserved Domains (3) summary
    cd10352
    Location:153239
    SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
    cd04372
    Location:376569
    RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...
    pfam00130
    Location:316368
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  3. XM_011515106.2XP_011513408.1  beta-chimaerin isoform X3

    Conserved Domains (3) summary
    cd10352
    Location:140226
    SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
    cd04372
    Location:363556
    RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...
    pfam00130
    Location:303355
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  4. XM_017011722.1XP_016867211.1  beta-chimaerin isoform X4

  5. XM_011515107.2XP_011513409.1  beta-chimaerin isoform X5

    Conserved Domains (3) summary
    cd10352
    Location:78164
    SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
    cd04372
    Location:301494
    RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...
    pfam00130
    Location:241293
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
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