1XA6


Conserved Protein Domain Family
RhoGAP_chimaerin

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cd04372: RhoGAP_chimaerin 
Click on image for an interactive view with Cn3D
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.
Statistics
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PSSM-Id: 239837
View PSSM: cd04372
Aligned: 6 rows
Threshold Bit Score: 337.567
Threshold Setting Gi: 7290597
Created: 14-Apr-2006
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
putative GTPasecatalytic
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:putative GTPase interaction site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                              #                                       #
1XA6_A      273 YCCDLTTLVKAhnt-qrPMVVDICIREIEARGLKSEGLYRVSGFTEhIEDVKMAFDRDGEKADISANVYPDINIITGALK 351
gi 7290597  302 FGTDLTTMVQLephhqiPFVVRRCVEEVEARGMLQEGIYRVSGFADeIEALKLALDREGEKTDMSETAYGNVNVIAGTLK 381
gi 50733038 651 YCCDLTTLVKAhnt-qrPMVVDSCIREIEARGLKSEGLYRVSGFTEhIEDVKMAFDRDGDKADISASIYPDINIIAGALK 729
gi 47085675 266 YSCDLTTLVKAhna-krPMVVDMCIREIEARGLQSEGLYRISGFSDlIEDVKLSFDRDGEKADISVNVYEDINVISGALK 344
gi 49115783 139 YSCDLTTLVKAhnt-prPMVVDMCIQEIETRGLQSEGLYRVSGFTEhIEDVKMSFDRDGDRADISSTSYPDINIITGALK 217
gi 91085797 258 FGIELTTLLTAhna-klPFVVTKCVAEVEARGLTTEGIYRLSGFAEeIEAIKMAFDKDGDKADLSQEKYPNVNVITGALK 336
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #                                                                    #  ##   
1XA6_A      352 LYFRDLPIPVITyDTYSKFIDAakisnaDERLEAVHEVLMlLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGP 431
gi 7290597  382 LYLRLLPVPLITfQAYPSFMAAgrtgkqAEQRQLMAEAVRrLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAP 461
gi 50733038 730 LYFRDLPIPVITyDTYSKFIEAakisnpDERLEAIHEVLMlLPAAHYETLRYLMIHLKKVTLHEKENFMNAENLGIVFGP 809
gi 47085675 345 LYFRDLPIPVITyDAYPRFIQAakltdpDERLEALHEALKlLPPAHCETLRYLMAHLKRVTQNEKDNLMNAENLGIVFGP 424
gi 49115783 218 LYFRDLPIPVITyDTYSKFVEAskipgaDERLEAIHNALMlLPPAHFETLRFLMIHLKKVALNVKENLMGAENLGIVFGP 297
gi 91085797 337 SYLRLLPIPLITfIVHPLLIDAmqhknhDLKMSSVKHALKsLPKAHYDTLKYMIEHLHRVSLHSAINKMNSHNLATVFAP 416
                       170       180       190
                ....*....|....*....|....*....|....*
Feature 1                           #              
1XA6_A      432 TLMrppedstlttlhdMRYQKLIVQILIENEDVLF 466
gi 7290597  462 TLIatpq-----hmtnLTEEIFMLSSLITHCKTIF 491
gi 50733038 810 TLMrppedstlatlndMRYQKLIVQILIENEDVLF 844
gi 47085675 425 TLMrapdldamtalndIRYQRQVVELLIKNEDILF 459
gi 49115783 298 TLMrppeenaltslndMRHQKQIVQLLIQNEDVLF 332
gi 91085797 417 TLIgpsesa-sdvmpdMTSDILLIETLITHCERIF 450

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