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DNAJB4 DnaJ heat shock protein family (Hsp40) member B4 [ Homo sapiens (human) ]

Gene ID: 11080, updated on 2-Oct-2018

Summary

Official Symbol
DNAJB4provided by HGNC
Official Full Name
DnaJ heat shock protein family (Hsp40) member B4provided by HGNC
Primary source
HGNC:HGNC:14886
See related
Ensembl:ENSG00000162616 MIM:611327; Vega:OTTHUMG00000040905
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DjB4; HLJ1; DNAJW
Summary
The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Expression
Ubiquitous expression in adrenal (RPKM 27.3), thyroid (RPKM 23.6) and 25 other tissues See more
Orthologs

Genomic context

See DNAJB4 in Genome Data Viewer
Location:
1p31.1
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (77979158..78017964)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (78444847..78483648)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene mitoguardin 1 Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 25 Neighboring gene NEXN antisense RNA 1 Neighboring gene nexilin F-actin binding protein Neighboring gene far upstream element binding protein 1 Neighboring gene nitrilase family member 2 pseudogene Neighboring gene GIPC PDZ domain containing family member 2 Neighboring gene RNA, U6 small nuclear 1102, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat downregulates the expression of DnaJ (Hsp40) homolog, subfamily B, member 4 (DNAJB4) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of ATPase activity IEA
Inferred from Electronic Annotation
more info
 
response to heat TAS
Traceable Author Statement
more info
PubMed 
response to unfolded protein TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
dnaJ homolog subfamily B member 4
Names
DnaJ (Hsp40) homolog, subfamily B, member 4
DnaJ-like heat shock protein 40
HSP40 homolog
heat shock 40 kDa protein 1 homolog
heat shock protein 40 homolog
human liver DnaJ-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317099.1NP_001304028.1  dnaJ homolog subfamily B member 4 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC096948, AC103591, BC034721, BI831822, BM972589
    Consensus CDS
    CCDS684.1
    UniProtKB/Swiss-Prot
    Q9UDY4
    Conserved Domains (1) summary
    COG0484
    Location:1332
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
  2. NM_001317100.1NP_001304029.1  dnaJ homolog subfamily B member 4 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC103591, BC034721, BM972589, BX441874, CN270601, DC349099, DC412631
    UniProtKB/Swiss-Prot
    Q9UDY4
    Conserved Domains (1) summary
    cd10747
    Location:118282
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
  3. NM_001317101.1NP_001304030.1  dnaJ homolog subfamily B member 4 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 4 and 5 both encode the same isoform (c).
    Source sequence(s)
    AC103591, BC034721, BM972589, BX441874, CN355216, DC412631
    UniProtKB/Swiss-Prot
    Q9UDY4
    UniProtKB/TrEMBL
    B4DNN2
    Conserved Domains (1) summary
    cd10747
    Location:43207
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
  4. NM_001317102.1NP_001304031.1  dnaJ homolog subfamily B member 4 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 4 and 5 both encode the same isoform (c).
    Source sequence(s)
    AC103591, BC034721, BM972589, DC412631
    UniProtKB/Swiss-Prot
    Q9UDY4
    UniProtKB/TrEMBL
    B4DNN2
    Conserved Domains (1) summary
    cd10747
    Location:43207
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
  5. NM_001317103.1NP_001304032.1  dnaJ homolog subfamily B member 4 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (d) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC103591, BC034721, BI910092, BM972589, DA354925, DA473487
    UniProtKB/Swiss-Prot
    Q9UDY4
    Conserved Domains (1) summary
    cl28246
    Location:471
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
  6. NM_007034.4NP_008965.2  dnaJ homolog subfamily B member 4 isoform a

    See identical proteins and their annotated locations for NP_008965.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC103591, BC034721, BM972589, DA354925
    Consensus CDS
    CCDS684.1
    UniProtKB/Swiss-Prot
    Q9UDY4
    Related
    ENSP00000359799.5, OTTHUMP00000038541, ENST00000370763.5, OTTHUMT00000098248
    Conserved Domains (1) summary
    COG0484
    Location:1332
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    77979158..78017964
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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