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Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 [ Mus musculus (house mouse) ]

Gene ID: 67035, updated on 12-May-2024

Summary

Official Symbol
Dnajb4provided by MGI
Official Full Name
DnaJ heat shock protein family (Hsp40) member B4provided by MGI
Primary source
MGI:MGI:1914285
See related
Ensembl:ENSMUSG00000028035 AllianceGenome:MGI:1914285
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700029A20Rik; 2010306G19Rik; 5730460G06Rik
Summary
Predicted to enable ATPase activator activity; chaperone binding activity; and unfolded protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in cytosol. Orthologous to human DNAJB4 (DnaJ heat shock protein family (Hsp40) member B4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 16.1), bladder adult (RPKM 10.9) and 24 other tissues See more
Orthologs
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Genomic context

See Dnajb4 in Genome Data Viewer
Location:
3 H3; 3 77.03 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (151887217..151915720, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (152181580..152210432, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene phosphatidylethanolamine binding protein 1 pseudogene Neighboring gene predicted gene, 31881 Neighboring gene GIPC PDZ domain containing family, member 2 Neighboring gene predicted gene, 40179 Neighboring gene STARR-seq mESC enhancer starr_09281 Neighboring gene STARR-seq mESC enhancer starr_09282 Neighboring gene STARR-seq mESC enhancer starr_09283 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:151866980-151867163 Neighboring gene STARR-positive B cell enhancer ABC_E2101 Neighboring gene predicted gene, 40180 Neighboring gene far upstream element (FUSE) binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_09284 Neighboring gene nexilin Neighboring gene STARR-positive B cell enhancer mm9_chr3:151922476-151922776

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Z disc ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dnaJ homolog subfamily B member 4
Names
DnaJ (Hsp40) homolog, subfamily B, member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356363.2NP_001343292.1  dnaJ homolog subfamily B member 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC123075
    Consensus CDS
    CCDS17915.1
    UniProtKB/Swiss-Prot
    Q3TS92, Q9D832, Q9D9U2
    Conserved Domains (1) summary
    COG0484
    Location:1332
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
  2. NM_001356364.2NP_001343293.1  dnaJ homolog subfamily B member 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC123075
    Conserved Domains (1) summary
    cd10747
    Location:43205
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
  3. NM_025926.6NP_080202.1  dnaJ homolog subfamily B member 4 isoform 1

    See identical proteins and their annotated locations for NP_080202.1

    Status: VALIDATED

    Source sequence(s)
    AC123075
    Consensus CDS
    CCDS17915.1
    UniProtKB/Swiss-Prot
    Q3TS92, Q9D832, Q9D9U2
    Related
    ENSMUSP00000053916.7, ENSMUST00000050073.13
    Conserved Domains (1) summary
    COG0484
    Location:1332
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
  4. NM_027287.6NP_081563.2  dnaJ homolog subfamily B member 4 isoform 1

    See identical proteins and their annotated locations for NP_081563.2

    Status: VALIDATED

    Source sequence(s)
    AC123075
    Consensus CDS
    CCDS17915.1
    UniProtKB/Swiss-Prot
    Q3TS92, Q9D832, Q9D9U2
    Related
    ENSMUSP00000114356.2, ENSMUST00000144950.8
    Conserved Domains (1) summary
    COG0484
    Location:1332
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    151887217..151915720 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163237.1XP_036019130.1  dnaJ homolog subfamily B member 4 isoform X1

    UniProtKB/Swiss-Prot
    Q3TS92, Q9D832, Q9D9U2
    Conserved Domains (1) summary
    COG0484
    Location:1332
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]