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CHD4 chromodomain helicase DNA binding protein 4 [ Homo sapiens (human) ]

Gene ID: 1108, updated on 8-Jul-2018
Official Symbol
CHD4provided by HGNC
Official Full Name
chromodomain helicase DNA binding protein 4provided by HGNC
Primary source
HGNC:HGNC:1919
See related
Ensembl:ENSG00000111642 MIM:603277; Vega:OTTHUMG00000169164
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CHD-4; Mi-2b; SIHIWES; Mi2-BETA
Summary
The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Expression
Ubiquitous expression in thyroid (RPKM 37.2), endometrium (RPKM 27.5) and 25 other tissues See more
Orthologs
See CHD4 in Genome Data Viewer
Location:
12p13.31
Exon count:
39
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (6570082..6607439, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6679248..6716551, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene intermediate filament family orphan 1 Neighboring gene NOP2 nucleolar protein Neighboring gene small Cajal body-specific RNA 11 Neighboring gene uncharacterized LOC105369631 Neighboring gene lysophosphatidic acid receptor 5 Neighboring gene acrosin binding protein

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Sifrim-Hitz-Weiss syndrome
MedGen: C4310688 OMIM: 617159 GeneReviews: Not available
not available

NHGRI GWAS Catalog

Description
A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
NHGRI GWA Catalog
  • Chromatin modifying enzymes, organism-specific biosystem (from REACTOME)
    Chromatin modifying enzymes, organism-specific biosystemEukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect i...
  • Chromatin organization, organism-specific biosystem (from REACTOME)
    Chromatin organization, organism-specific biosystemChromatin organization refers to the composition and conformation of complexes between DNA, protein and RNA. It is determined by processes that result in the specification, formation or maintenance o...
  • ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression, organism-specific biosystem (from REACTOME)
    ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression, organism-specific biosystemAbout half of the rRNA genes in the genome are actively expressed, being transcribed by RNA polymerase I (reviewed in Nemeth and Langst 2008, Bartova et al. 2010, Goodfellow and Zomerdijk 2012, Grumm...
  • Epigenetic regulation of gene expression, organism-specific biosystem (from REACTOME)
    Epigenetic regulation of gene expression, organism-specific biosystemEpigenetic processes regulate gene expression by modulating the frequency, rate, or extent of gene expression in a mitotically or meiotically heritable way that does not entail a change in the DNA se...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • HDACs deacetylate histones, organism-specific biosystem (from REACTOME)
    HDACs deacetylate histones, organism-specific biosystemLysine deacetylases (KDACs), historically referred to as histone deacetylases (HDACs), are divided into the Rpd3/Hda1 metal-dependent 'classical HDAC family' (de Ruijter et al. 2003, Verdin et al. 2...
  • Positive epigenetic regulation of rRNA expression, organism-specific biosystem (from REACTOME)
    Positive epigenetic regulation of rRNA expression, organism-specific biosystemTranscription of rRNA genes is controlled by epigenetic activation and repression (reviewed in Percipalle and Farrants 2006, McStay and Grummt 2008, Goodfellow and Zomerdijk 2012, Grummt and Langst 2...
  • RNA Polymerase I Promoter Clearance, organism-specific biosystem (from REACTOME)
    RNA Polymerase I Promoter Clearance, organism-specific biosystemPromoter clearance is one of the rate-limiting steps in Polymerase I transcription. This step is composed of three phases, promoter opening, transcription initiation and promoter escape.
  • RNA Polymerase I Transcription, organism-specific biosystem (from REACTOME)
    RNA Polymerase I Transcription, organism-specific biosystemThe rRNA genes are transcribed by RNA polymerase I, one of three eukaryotic nuclear RNA polymerases. The polymerase is a multisubunit complex, composed of two large subunits (the most conserved porti...
  • RNA Polymerase I Transcription Initiation, organism-specific biosystem (from REACTOME)
    RNA Polymerase I Transcription Initiation, organism-specific biosystemDuring initiation the double-stranded DNA must be melted and transcription begins. SL1 forms and interacts with UBF-1 and the rDNA promoter. It is this platform that will recruit active RNA polymeras...
  • RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription, organism-specific biosystem (from REACTOME)
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription, organism-specific biosystemTranscription by RNA Polymerase I, RNA Polymerase III and transcription from mitochondrial promoters.
  • Regulation of TP53 Activity, organism-specific biosystem (from REACTOME)
    Regulation of TP53 Activity, organism-specific biosystemProtein stability and transcriptional activity of TP53 (p53) tumor suppressor are regulated by post-translational modifications that include ubiquitination, phosphorylation, acetylation, methylation,...
  • Regulation of TP53 Activity through Acetylation, organism-specific biosystem (from REACTOME)
    Regulation of TP53 Activity through Acetylation, organism-specific biosystemTranscriptional activity of TP53 is positively regulated by acetylation of several of its lysine residues. BRD7 binds TP53 and promotes acetylation of TP53 lysine residue K382 by acetyltransferase EP...
  • Signaling events mediated by HDAC Class I, organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by HDAC Class I, organism-specific biosystem
    Signaling events mediated by HDAC Class I
  • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
    Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...
  • Viral carcinogenesis, organism-specific biosystem (from KEGG)
    Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
  • Viral carcinogenesis, conserved biosystem (from KEGG)
    Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp686E06161

Gene Ontology Provided by GOA

Process Evidence Code Pubs
ATP-dependent chromatin remodeling HDA PubMed 
DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
 
histone deacetylation IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
NuRD complex IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
nuclear chromatin HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
protein-containing complex HDA PubMed 
Preferred Names
chromodomain-helicase-DNA-binding protein 4
Names
ATP-dependent helicase CHD4
Mi-2 autoantigen 218 kDa protein
NP_001264.2
NP_001284482.1
XP_005253725.1
XP_006719021.1
XP_006719022.1
XP_006719023.1
XP_006719024.1
XP_006719025.1
XP_016874214.1
XP_016874215.1
XP_016874216.1
XP_016874217.1
XP_016874218.1
XP_016874219.1
XP_016874220.1
XP_016874221.1
XP_016874222.1
XP_016874223.1
XP_024304570.1
XP_024304571.1
XP_024304572.1
XP_024304573.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052823.1 RefSeqGene

    Range
    5007..42358
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273.4NP_001264.2  chromodomain-helicase-DNA-binding protein 4 isoform 1

    See identical proteins and their annotated locations for NP_001264.2

    Status: REVIEWED

    Source sequence(s)
    AA099889, AC006064, BC038596, BP234473, X86691
    Consensus CDS
    CCDS8552.1
    UniProtKB/Swiss-Prot
    Q14839
    Related
    ENSP00000440542.2, ENST00000544040.6
    Conserved Domains (12) summary
    smart00298
    Location:622676
    CHROMO; Chromatin organization modifier domain
    cd00024
    Location:540577
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    cd00046
    Location:746904
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd15531
    Location:372414
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:451493
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam00176
    Location:7291025
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:10681164
    Helicase_C; Helicase conserved C-terminal domain
    pfam06461
    Location:13851521
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:13021352
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam06614
    Location:15171649
    Neuromodulin; Neuromodulin
    pfam08073
    Location:164216
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17261896
    CHDCT2; CHDCT2 (NUC038) domain
  2. NM_001297553.2NP_001284482.1  chromodomain-helicase-DNA-binding protein 4 isoform 2

    See identical proteins and their annotated locations for NP_001284482.1

    Status: REVIEWED

    Source sequence(s)
    AC006064, BC038596, CR936680, X86691
    Consensus CDS
    CCDS76510.1
    UniProtKB/Swiss-Prot
    Q14839
    UniProtKB/TrEMBL
    F5GWX5
    Conserved Domains (12) summary
    smart00298
    Location:615669
    CHROMO; Chromatin organization modifier domain
    cd00024
    Location:533570
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    cd00046
    Location:739897
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd15531
    Location:365407
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:444486
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam00176
    Location:7221018
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:10611157
    Helicase_C; Helicase conserved C-terminal domain
    pfam06461
    Location:13781514
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:12951345
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam06614
    Location:15101642
    Neuromodulin; Neuromodulin
    pfam08073
    Location:157209
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17191889
    CHDCT2; CHDCT2 (NUC038) domain
  3. NM_001363606.1NP_001350535.1  chromodomain-helicase-DNA-binding protein 4 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC006064
    Consensus CDS
    CCDS86267.1
    Conserved Domains (10) summary
    smart00298
    Location:609663
    CHROMO; Chromatin organization modifier domain
    cd00024
    Location:527564
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    cd15531
    Location:359401
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:438480
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam06461
    Location:13721508
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:12891339
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:164217
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17151886
    CHDCT2; CHDCT2 (NUC038) domain
    cl25758
    Location:14981633
    DUF4775; Domain of unknown function (DUF4775)
    cl26465
    Location:7111268
    SNF2_N; SNF2 family N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    6570082..6607439 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018731.1XP_016874220.1  chromodomain-helicase-DNA-binding protein 4 isoform X17

    Related
    ENSP00000496543.1, ENST00000645645.1
  2. XM_017018730.1XP_016874219.1  chromodomain-helicase-DNA-binding protein 4 isoform X16

  3. XM_006718962.1XP_006719025.1  chromodomain-helicase-DNA-binding protein 4 isoform X15

    Related
    ENSP00000349508.3, ENST00000357008.7
    Conserved Domains (10) summary
    smart00298
    Location:609663
    CHROMO; Chromatin organization modifier domain
    cd00024
    Location:527564
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    cd15531
    Location:359401
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:438480
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam06461
    Location:13721508
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:12891339
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:164217
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17151886
    CHDCT2; CHDCT2 (NUC038) domain
    cl25758
    Location:14981633
    DUF4775; Domain of unknown function (DUF4775)
    cl26465
    Location:7111268
    SNF2_N; SNF2 family N-terminal domain
  4. XM_024448804.1XP_024304572.1  chromodomain-helicase-DNA-binding protein 4 isoform X4

    Conserved Domains (10) summary
    smart00298
    Location:609663
    CHROMO; Chromatin organization modifier domain
    cd00024
    Location:527564
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    cd15531
    Location:359401
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:438480
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam06461
    Location:14001536
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:12891339
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:164217
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17411912
    CHDCT2; CHDCT2 (NUC038) domain
    cl25758
    Location:15261659
    DUF4775; Domain of unknown function (DUF4775)
    cl26465
    Location:7111268
    SNF2_N; SNF2 family N-terminal domain
  5. XM_017018728.1XP_016874217.1  chromodomain-helicase-DNA-binding protein 4 isoform X11

  6. XM_017018727.1XP_016874216.1  chromodomain-helicase-DNA-binding protein 4 isoform X10

  7. XM_006718960.1XP_006719023.1  chromodomain-helicase-DNA-binding protein 4 isoform X8

    Conserved Domains (11) summary
    smart00298
    Location:622676
    CHROMO; Chromatin organization modifier domain
    cd00024
    Location:540577
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    cd00046
    Location:746904
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd15531
    Location:372414
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:451493
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam00176
    Location:7291025
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:10681164
    Helicase_C; Helicase conserved C-terminal domain
    pfam06461
    Location:13841520
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:13011351
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:164216
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17271898
    CHDCT2; CHDCT2 (NUC038) domain
  8. XM_017018726.1XP_016874215.1  chromodomain-helicase-DNA-binding protein 4 isoform X9

  9. XM_017018725.1XP_016874214.1  chromodomain-helicase-DNA-binding protein 4 isoform X7

    Related
    ENSP00000493471.1, ENST00000645005.1
  10. XM_006718959.1XP_006719022.1  chromodomain-helicase-DNA-binding protein 4 isoform X6

    Conserved Domains (11) summary
    smart00298
    Location:622676
    CHROMO; Chromatin organization modifier domain
    cd00024
    Location:540577
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    cd00046
    Location:746904
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd15531
    Location:372414
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:451493
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam00176
    Location:7291025
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:10681164
    Helicase_C; Helicase conserved C-terminal domain
    pfam06461
    Location:13851521
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:13021352
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:164216
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17281899
    CHDCT2; CHDCT2 (NUC038) domain
  11. XM_006718958.1XP_006719021.1  chromodomain-helicase-DNA-binding protein 4 isoform X2

    UniProtKB/Swiss-Prot
    Q14839
    Related
    ENSP00000496634.1, OTTHUMP00000240273, ENST00000645095.1, OTTHUMT00000402631
    Conserved Domains (12) summary
    smart00298
    Location:622676
    CHROMO; Chromatin organization modifier domain
    cd00024
    Location:540577
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    cd00046
    Location:746904
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd15531
    Location:372414
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:451493
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam00176
    Location:7291025
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:10681164
    Helicase_C; Helicase conserved C-terminal domain
    pfam06461
    Location:14131549
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:13021352
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam06614
    Location:15451677
    Neuromodulin; Neuromodulin
    pfam08073
    Location:164216
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17541924
    CHDCT2; CHDCT2 (NUC038) domain
  12. XM_024448802.1XP_024304570.1  chromodomain-helicase-DNA-binding protein 4 isoform X1

    Conserved Domains (10) summary
    smart00298
    Location:622676
    CHROMO; Chromatin organization modifier domain
    cd00024
    Location:540577
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    cd15531
    Location:372414
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:451493
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam06461
    Location:14131549
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:13021352
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:164217
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17541925
    CHDCT2; CHDCT2 (NUC038) domain
    cl25758
    Location:15391672
    DUF4775; Domain of unknown function (DUF4775)
    cl26465
    Location:7241281
    SNF2_N; SNF2 family N-terminal domain
  13. XM_017018734.1XP_016874223.1  chromodomain-helicase-DNA-binding protein 4 isoform X20

    Related
    ENSP00000494574.1, ENST00000646806.1
  14. XM_017018733.1XP_016874222.1  chromodomain-helicase-DNA-binding protein 4 isoform X19

  15. XM_017018732.1XP_016874221.1  chromodomain-helicase-DNA-binding protein 4 isoform X18

  16. XM_024448805.1XP_024304573.1  chromodomain-helicase-DNA-binding protein 4 isoform X5

    Related
    ENSP00000494456.1, ENST00000642879.1
    Conserved Domains (10) summary
    smart00298
    Location:602656
    CHROMO; Chromatin organization modifier domain
    cd00024
    Location:520557
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    cd15531
    Location:352394
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:431473
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam06461
    Location:13931529
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:12821332
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:157210
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17341904
    CHDCT2; CHDCT2 (NUC038) domain
    cl25758
    Location:15191652
    DUF4775; Domain of unknown function (DUF4775)
    cl26465
    Location:7041261
    SNF2_N; SNF2 family N-terminal domain
  17. XM_005253668.3XP_005253725.1  chromodomain-helicase-DNA-binding protein 4 isoform X14

    See identical proteins and their annotated locations for XP_005253725.1

    UniProtKB/TrEMBL
    F5GWX5
    Related
    ENSP00000496163.1, OTTHUMP00000240274, ENST00000645022.1, OTTHUMT00000402632
    Conserved Domains (12) summary
    smart00298
    Location:615669
    CHROMO; Chromatin organization modifier domain
    cd00024
    Location:533570
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    cd00046
    Location:739897
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd15531
    Location:365407
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:444486
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam00176
    Location:7221018
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:10611157
    Helicase_C; Helicase conserved C-terminal domain
    pfam06461
    Location:13781514
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:12951345
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam06614
    Location:15101642
    Neuromodulin; Neuromodulin
    pfam08073
    Location:157209
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17191889
    CHDCT2; CHDCT2 (NUC038) domain
  18. XM_017018729.1XP_016874218.1  chromodomain-helicase-DNA-binding protein 4 isoform X13

    Related
    ENSP00000493619.1, ENST00000642594.1
  19. XM_006718961.2XP_006719024.1  chromodomain-helicase-DNA-binding protein 4 isoform X12

    Conserved Domains (11) summary
    smart00298
    Location:615669
    CHROMO; Chromatin organization modifier domain
    cd00024
    Location:533570
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    cd00046
    Location:739897
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd15531
    Location:365407
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:444486
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam00176
    Location:7221018
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:10611157
    Helicase_C; Helicase conserved C-terminal domain
    pfam06461
    Location:13781514
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:12951345
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:157209
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17211892
    CHDCT2; CHDCT2 (NUC038) domain
  20. XM_024448803.1XP_024304571.1  chromodomain-helicase-DNA-binding protein 4 isoform X3

    Related
    ENSP00000496707.1, ENST00000644289.1
    Conserved Domains (10) summary
    smart00298
    Location:615669
    CHROMO; Chromatin organization modifier domain
    cd00024
    Location:533570
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    cd15531
    Location:365407
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:444486
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam06461
    Location:14061542
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:12951345
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:157210
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17471918
    CHDCT2; CHDCT2 (NUC038) domain
    cl25758
    Location:15321665
    DUF4775; Domain of unknown function (DUF4775)
    cl26465
    Location:7171274
    SNF2_N; SNF2 family N-terminal domain
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