1AP0,1GUW,1G6Z


Conserved Protein Domain Family
CHROMO

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cd00024: CHROMO (this model, PSSM-Id:237991 is obsolete and has been replaced by 349274)
Click on image for an interactive view with Cn3D
Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence implicates the chromo domain in the binding activity of these proteins to methylated histone tails and maybe RNA. May occur as single instance, in a tandem arrangement or followd by a related "chromo shadow" domain.
Statistics
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PSSM-Id: 237991
Aligned: 121 rows
Threshold Bit Score: 30.31
Threshold Setting Gi: 1709132
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
histone binding
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:histone binding site
Evidence:
  • Structure:1GUW binds the Lysine 9-Methyl Histone H3 N-terminal Peptide
    View structure with Cn3D
  • Structure:determinants of specificity for methylated Lys
    View structure with Cn3D
  • Comment:induced-fit mechanism: the flexible N-terminal tail moves closer in the peptide-bound state

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        #                                     # #  #   #   #   ##              
1AP0        12 EEYVVEKVLDRRVvk-------------------gkVEYLLKWKGFsdeDNTWEPEENLdcp--dlIAEFLQS 63   house mouse
1GUW_A      12 EEYVVEKVLDRRVvk-------------------gkVEYLLKWKGFsdeDNTWEPEENLdcp--dlIAEFLQS 63   house mouse
3024755     24 DEWPLAEILSVKDis-------------------grKLFYVHYIDFnkrLDEWVTHERLdl----kKIQFPKK 73   human
584704      60 NTLHAAEIIKTRKtke------------------naEEFYVHYVGLnrrQNEWVDKSRVlqakqikTEELNNT 114  Iberian ribbed newt
7492650     14 KSYEAKDIVYKSKvfafkdgeyrkaeilmiqkrtrgVVYYVHYNDYnkrLDEWITIDNIdl---skGIEYPPP 83   fission yeast
NP_586181   22 EEVFKAEILGKRAgk-------------------sgLEFYVHYVELnrrLDEWIDGSMIdlgdpaqIEIPKKK 75   Encephalitozoon cuniculi
NP_003066  183 GNLEEEEWVRPVMkr--------------------dKQVLLHWGYYpdsYDTWIPASEIea----sVEDAPTP 231  human
1311667     33 GSQHDADIVKTRYnkq-----------------agrEEYYVHYVGLnrrQNEWVDKSRLvltkppkEVETNGT 88   African clawed frog
3023717     33 DEERLAEILSINTrk-------------------apPKFYVHYVNYnkrLDEWITTDRInl---dkEVLYPKL 83   baker's yeast
7508719     44 EEERWAEVISRCRaan------------------gsIKFYVHYIDCnrrLDEWVQSDRLnl----aSCELPKK 94   Caenorhabditis elegans

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