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Chd4 chromodomain helicase DNA binding protein 4 [ Mus musculus (house mouse) ]

Gene ID: 107932, updated on 9-Mar-2023

Summary

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Official Symbol
Chd4provided by MGI
Official Full Name
chromodomain helicase DNA binding protein 4provided by MGI
Primary source
MGI:MGI:1344380
See related
Ensembl:ENSMUSG00000063870 AllianceGenome:MGI:1344380
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mi-2beta; mKIAA4075; D6Ertd380e; 9530019N15Rik
Summary
Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity; histone deacetylase binding activity; and transcription coregulator binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and terminal button organization. Predicted to act upstream of or within chromatin organization. Located in nucleus. Part of NuRD complex and protein-DNA complex. Is expressed in several structures, including alimentary system; branchial arch; cardiovascular system; genitourinary system; and nervous system. Orthologous to human CHD4 (chromodomain helicase DNA binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 47.4), CNS E14 (RPKM 29.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Chd4 in Genome Data Viewer
Location:
6 F2; 6 59.28 cM
Exon count:
40
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (125072943..125107554)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (125095980..125130591)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene proacrosin binding protein Neighboring gene lysophosphatidic acid receptor 5 Neighboring gene microRNA 7045 Neighboring gene predicted gene, 23751 Neighboring gene NOP2 nucleolar protein Neighboring gene intermediate filament family orphan 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CHD4 acts as a critical regulator in the survival of spermatogonial stem cells in mice†. Li P, et al. Biol Reprod, 2022 Nov 14. PMID 35980806
  2. CHD4 ensures stem cell lineage fidelity during skeletal muscle regeneration. Sreenivasan K, et al. Stem Cell Reports, 2021 Sep 14. PMID 34450038, Free PMC Article
  3. The chromatin remodeling enzyme Chd4 regulates genome architecture in the mouse brain. Goodman JV, et al. Nat Commun, 2020 Jul 9. PMID 32647123, Free PMC Article
  4. Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis. Sher F, et al. Nat Genet, 2019 Jul. PMID 31253978, Free PMC Article
  5. Chromatin restriction by the nucleosome remodeler Mi-2β and functional interplay with lineage-specific transcription regulators control B-cell differentiation. Yoshida T, et al. Genes Dev, 2019 Jul 1. PMID 31123064, Free PMC Article

See all (131) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CHD4 acts as a critical regulator in the survival of spermatogonial stem cells in micedagger.
    Title: CHD4 acts as a critical regulator in the survival of spermatogonial stem cells in mice†.
  2. Interplay between the Chd4/NuRD Complex and the Transcription Factor Znf219 Controls Cardiac Cell Identity.
    Title: Interplay between the Chd4/NuRD Complex and the Transcription Factor Znf219 Controls Cardiac Cell Identity.
  3. CHD4 ensures stem cell lineage fidelity during skeletal muscle regeneration.
    Title: CHD4 ensures stem cell lineage fidelity during skeletal muscle regeneration.
  4. A regulatory role for CHD4 in maintenance of the spermatogonial stem cell pool.
    Title: A regulatory role for CHD4 in maintenance of the spermatogonial stem cell pool.
  5. The NuRD chromatin-remodeling complex enzyme CHD4 prevents hypoxia-induced endothelial Ripk3 transcription and murine embryonic vascular rupture.
    Title: The NuRD chromatin-remodeling complex enzyme CHD4 prevents hypoxia-induced endothelial Ripk3 transcription and murine embryonic vascular rupture.
  6. Chd4 choreographs self-antigen expression for central immune tolerance.
    Title: Chd4 choreographs self-antigen expression for central immune tolerance.
  7. The chromatin remodeling enzyme Chd4 regulates genome architecture in the mouse brain.
    Title: The chromatin remodeling enzyme Chd4 regulates genome architecture in the mouse brain.
  8. CHD4 is essential for early B cell development. Loss of CHD4 in mature B cells impairs class switch recombination. CHD4 represses p53 expression to promote B cell proliferation.
    Title: Distinct Requirements of CHD4 during B Cell Development and Antibody Response.
  9. It validates a distinct molecular axis, Gatad2a-Chd4-Mbd3, within Mbd3/NuRD as being critical for blocking reestablishment of naive pluripotency and further highlight signaling-dependent and post-translational modifications of Mbd3/NuRD that influence its interactions and assembly.
    Title: Neutralizing Gatad2a-Chd4-Mbd3/NuRD Complex Facilitates Deterministic Induction of Naive Pluripotency.
  10. Mi-2beta promotes pre-B-cell differentiation by providing repression capabilities to distinct lineage-specific transcription factor-based regulatory networks.
    Title: Chromatin restriction by the nucleosome remodeler Mi-2β and functional interplay with lineage-specific transcription regulators control B-cell differentiation.
Submit: New GeneRIF Correction See all GeneRIFs (34)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (7)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4075, MGC11769

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP-dependent chromatin remodeler activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables ATP-dependent chromatin remodeler activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coregulator binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in histone deacetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of cell fate specification NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of stem cell differentiation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of synapse assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in terminal button organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of NuRD complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
part_of NuRD complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of NuRD complex ISO
Inferred from Sequence Orthology
more info
  
part_of NuRD complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cerebellar granule cell to Purkinje cell synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-DNA complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in site of DNA damage ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
chromodomain-helicase-DNA-binding protein 4
Names
CHD-4
Mi-2 beta
NP_001333539.1
XP_006505344.1
XP_006505348.1
XP_006505349.1
XP_006505350.1
XP_017176783.1
XP_017176784.1
XP_017176785.1
XP_030110913.1
XP_030110914.1
XP_036021615.1
XP_036021616.1
XP_036021617.1
XP_036021618.1
XP_036021619.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346610.2 → NP_001333539.1  chromodomain-helicase-DNA-binding protein 4 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC134529, AC166162
    Consensus CDS
    CCDS20543.1
    UniProtKB/Swiss-Prot
    Q6PDQ2
    UniProtKB/TrEMBL
    Q3ULG0, Q8BM83
    Related
    ENSMUSP00000060054.9, ENSMUST00000056889.15

  2. NM_001403592.1 → NP_001390521.1  chromodomain-helicase-DNA-binding protein 4 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC134529, AC166162
    UniProtKB/TrEMBL
    E9QAS5

  3. NM_001403593.1 → NP_001390522.1  chromodomain-helicase-DNA-binding protein 4 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC134529, AC166162

  4. NM_001403594.1 → NP_001390523.1  chromodomain-helicase-DNA-binding protein 4 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC134529, AC166162

  5. NM_001403595.1 → NP_001390524.1  chromodomain-helicase-DNA-binding protein 4 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC134529, AC166162

  6. NM_001403596.1 → NP_001390525.1  chromodomain-helicase-DNA-binding protein 4 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC134529, AC166162

  7. NM_001403597.1 → NP_001390526.1  chromodomain-helicase-DNA-binding protein 4 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC134529, AC166162
    UniProtKB/TrEMBL
    E9QAS4

  8. NM_001403598.1 → NP_001390527.1  chromodomain-helicase-DNA-binding protein 4 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC134529, AC166162
    UniProtKB/Swiss-Prot
    Q6PDQ2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    125072943..125107554
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321295.2 → XP_017176784.1  chromodomain-helicase-DNA-binding protein 4 isoform X6

    Conserved Domains (11) summary
    PLN03142
    Location:717 → 1274
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd15531
    Location:365 → 407
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:444 → 486
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd18662
    Location:612 → 666
    CD2_tandem_CHD3-4_like; repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    cd18667
    Location:491 → 569
    CD1_tandem_CHD3-4_like; repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    cd18056
    Location:719 → 950
    DEXHc_CHD4; DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4
    pfam06461
    Location:1378 → 1514
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:1295 → 1344
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:157 → 210
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:1729 → 1900
    CHDCT2; CHDCT2 (NUC038) domain
    pfam16001
    Location:1529 → 1647
    DUF4775; Domain of unknown function (DUF4775)

  2. XM_036165722.1 → XP_036021615.1  chromodomain-helicase-DNA-binding protein 4 isoform X7

    Conserved Domains (10) summary
    PLN03142
    Location:717 → 1274
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd15531
    Location:365 → 407
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:444 → 486
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd18662
    Location:612 → 666
    CD2_tandem_CHD3-4_like; repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    cd18667
    Location:491 → 569
    CD1_tandem_CHD3-4_like; repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    cd18056
    Location:719 → 950
    DEXHc_CHD4; DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4
    pfam06461
    Location:1377 → 1513
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:1294 → 1337
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:157 → 210
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:1728 → 1853
    CHDCT2; CHDCT2 (NUC038) domain

  3. XM_017321296.2 → XP_017176785.1  chromodomain-helicase-DNA-binding protein 4 isoform X12

    UniProtKB/TrEMBL
    E9QAS4
    Related
    ENSMUSP00000108011.2, ENSMUST00000112392.8
    Conserved Domains (11) summary
    PLN03142
    Location:704 → 1261
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd15531
    Location:352 → 394
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:431 → 473
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd18662
    Location:599 → 653
    CD2_tandem_CHD3-4_like; repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    cd18667
    Location:478 → 556
    CD1_tandem_CHD3-4_like; repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    cd18056
    Location:706 → 937
    DEXHc_CHD4; DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4
    pfam06461
    Location:1365 → 1501
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:1282 → 1331
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:157 → 210
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:1716 → 1886
    CHDCT2; CHDCT2 (NUC038) domain
    pfam16001
    Location:1516 → 1634
    DUF4775; Domain of unknown function (DUF4775)

  4. XM_036165725.1 → XP_036021618.1  chromodomain-helicase-DNA-binding protein 4 isoform X13

    Conserved Domains (10) summary
    PLN03142
    Location:704 → 1261
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd15531
    Location:352 → 394
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:431 → 473
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd18662
    Location:599 → 653
    CD2_tandem_CHD3-4_like; repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    cd18667
    Location:478 → 556
    CD1_tandem_CHD3-4_like; repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    cd18056
    Location:706 → 937
    DEXHc_CHD4; DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4
    pfam06461
    Location:1364 → 1500
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:1281 → 1324
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:157 → 210
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:1715 → 1840
    CHDCT2; CHDCT2 (NUC038) domain

  5. XM_030255054.2 → XP_030110914.1  chromodomain-helicase-DNA-binding protein 4 isoform X11

    Conserved Domains (11) summary
    PLN03142
    Location:704 → 1261
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd15531
    Location:352 → 394
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:431 → 473
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd18662
    Location:599 → 653
    CD2_tandem_CHD3-4_like; repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    cd18667
    Location:478 → 556
    CD1_tandem_CHD3-4_like; repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    cd18056
    Location:706 → 937
    DEXHc_CHD4; DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4
    pfam06461
    Location:1365 → 1501
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:1282 → 1331
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:157 → 210
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:1716 → 1887
    CHDCT2; CHDCT2 (NUC038) domain
    pfam16001
    Location:1516 → 1634
    DUF4775; Domain of unknown function (DUF4775)

  6. XM_006505281.1 → XP_006505344.1  chromodomain-helicase-DNA-binding protein 4 isoform X1

    Conserved Domains (11) summary
    PLN03142
    Location:724 → 1281
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd15531
    Location:372 → 414
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:451 → 493
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd18662
    Location:619 → 673
    CD2_tandem_CHD3-4_like; repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    cd18667
    Location:498 → 576
    CD1_tandem_CHD3-4_like; repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    cd18056
    Location:726 → 957
    DEXHc_CHD4; DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4
    pfam06461
    Location:1413 → 1549
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:1302 → 1351
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:164 → 217
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:1764 → 1934
    CHDCT2; CHDCT2 (NUC038) domain
    pfam16001
    Location:1564 → 1682
    DUF4775; Domain of unknown function (DUF4775)

  7. XM_006505285.1 → XP_006505348.1  chromodomain-helicase-DNA-binding protein 4 isoform X2

    Conserved Domains (11) summary
    PLN03142
    Location:724 → 1281
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd15531
    Location:372 → 414
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:451 → 493
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd18662
    Location:619 → 673
    CD2_tandem_CHD3-4_like; repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    cd18667
    Location:498 → 576
    CD1_tandem_CHD3-4_like; repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    cd18056
    Location:726 → 957
    DEXHc_CHD4; DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4
    pfam06461
    Location:1385 → 1521
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:1302 → 1351
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:164 → 217
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:1736 → 1907
    CHDCT2; CHDCT2 (NUC038) domain
    pfam16001
    Location:1536 → 1654
    DUF4775; Domain of unknown function (DUF4775)

  8. XM_006505286.1 → XP_006505349.1  chromodomain-helicase-DNA-binding protein 4 isoform X3

    UniProtKB/TrEMBL
    E9QAS5
    Related
    ENSMUSP00000108009.2, ENSMUST00000112390.8
    Conserved Domains (11) summary
    PLN03142
    Location:724 → 1281
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd15531
    Location:372 → 414
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:451 → 493
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd18662
    Location:619 → 673
    CD2_tandem_CHD3-4_like; repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    cd18667
    Location:498 → 576
    CD1_tandem_CHD3-4_like; repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    cd18056
    Location:726 → 957
    DEXHc_CHD4; DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4
    pfam06461
    Location:1385 → 1521
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:1302 → 1351
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:164 → 217
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:1736 → 1906
    CHDCT2; CHDCT2 (NUC038) domain
    pfam16001
    Location:1536 → 1654
    DUF4775; Domain of unknown function (DUF4775)

  9. XM_006505287.1 → XP_006505350.1  chromodomain-helicase-DNA-binding protein 4 isoform X4

    Conserved Domains (11) summary
    PLN03142
    Location:724 → 1281
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd15531
    Location:372 → 414
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:451 → 493
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd18662
    Location:619 → 673
    CD2_tandem_CHD3-4_like; repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    cd18667
    Location:498 → 576
    CD1_tandem_CHD3-4_like; repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    cd18056
    Location:726 → 957
    DEXHc_CHD4; DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4
    pfam06461
    Location:1384 → 1520
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:1301 → 1350
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:164 → 217
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:1735 → 1906
    CHDCT2; CHDCT2 (NUC038) domain
    pfam16001
    Location:1535 → 1653
    DUF4775; Domain of unknown function (DUF4775)

  10. XM_017321294.1 → XP_017176783.1  chromodomain-helicase-DNA-binding protein 4 isoform X5

    Conserved Domains (11) summary
    PLN03142
    Location:724 → 1281
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd15531
    Location:372 → 414
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:451 → 493
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd18662
    Location:619 → 673
    CD2_tandem_CHD3-4_like; repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    cd18667
    Location:498 → 576
    CD1_tandem_CHD3-4_like; repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    cd18056
    Location:726 → 957
    DEXHc_CHD4; DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4
    pfam06461
    Location:1384 → 1520
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:1301 → 1350
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:164 → 217
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:1735 → 1905
    CHDCT2; CHDCT2 (NUC038) domain
    pfam16001
    Location:1535 → 1653
    DUF4775; Domain of unknown function (DUF4775)

  11. XM_030255053.1 → XP_030110913.1  chromodomain-helicase-DNA-binding protein 4 isoform X8

    Conserved Domains (11) summary
    PLN03142
    Location:711 → 1268
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd15531
    Location:359 → 401
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:438 → 480
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd18662
    Location:606 → 660
    CD2_tandem_CHD3-4_like; repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    cd18667
    Location:485 → 563
    CD1_tandem_CHD3-4_like; repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    cd18056
    Location:713 → 944
    DEXHc_CHD4; DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4
    pfam06461
    Location:1372 → 1508
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:1289 → 1338
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:164 → 217
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:1723 → 1894
    CHDCT2; CHDCT2 (NUC038) domain
    pfam16001
    Location:1523 → 1641
    DUF4775; Domain of unknown function (DUF4775)

  12. XM_036165723.1 → XP_036021616.1  chromodomain-helicase-DNA-binding protein 4 isoform X9

    Conserved Domains (10) summary
    PLN03142
    Location:711 → 1268
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd15531
    Location:359 → 401
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:438 → 480
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd18662
    Location:606 → 660
    CD2_tandem_CHD3-4_like; repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    cd18667
    Location:485 → 563
    CD1_tandem_CHD3-4_like; repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    cd18056
    Location:713 → 944
    DEXHc_CHD4; DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4
    pfam06461
    Location:1372 → 1508
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:1289 → 1332
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:164 → 217
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:1723 → 1848
    CHDCT2; CHDCT2 (NUC038) domain

  13. XM_036165724.1 → XP_036021617.1  chromodomain-helicase-DNA-binding protein 4 isoform X10

    Conserved Domains (10) summary
    PLN03142
    Location:711 → 1268
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd15531
    Location:359 → 401
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:438 → 480
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd18662
    Location:606 → 660
    CD2_tandem_CHD3-4_like; repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    cd18667
    Location:485 → 563
    CD1_tandem_CHD3-4_like; repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    cd18056
    Location:713 → 944
    DEXHc_CHD4; DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4
    pfam06461
    Location:1371 → 1507
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:1288 → 1331
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:164 → 217
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:1722 → 1847
    CHDCT2; CHDCT2 (NUC038) domain

  14. XM_036165726.1 → XP_036021619.1  chromodomain-helicase-DNA-binding protein 4 isoform X14

    Conserved Domains (7) summary
    PLN03142
    Location:724 → 1281
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd15531
    Location:372 → 414
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:451 → 493
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd18662
    Location:619 → 673
    CD2_tandem_CHD3-4_like; repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    cd18667
    Location:498 → 576
    CD1_tandem_CHD3-4_like; repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    cd18056
    Location:726 → 957
    DEXHc_CHD4; DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4
    pfam08073
    Location:164 → 217
    CHDNT; CHDNT (NUC034) domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PDQ2.1 GenPept UniProtKB/Swiss-Prot:Q6PDQ2

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