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RER1 retention in endoplasmic reticulum sorting receptor 1 [ Homo sapiens (human) ]

Gene ID: 11079, updated on 7-Jun-2020

Summary

Official Symbol
RER1provided by HGNC
Official Full Name
retention in endoplasmic reticulum sorting receptor 1provided by HGNC
Primary source
HGNC:HGNC:30309
See related
Ensembl:ENSG00000157916
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a multi-pass membrane protein that is localized to the golgi apparatus. It is involved in the retention of endoplasmic reticulum (ER) membrane proteins in the ER and retrieval of ER membrane proteins from the early Golgi compartment to facilitate gamma-secretase complex assembly. [provided by RefSeq, Oct 2009]
Expression
Ubiquitous expression in colon (RPKM 20.8), adrenal (RPKM 20.4) and 25 other tissues See more
Orthologs

Genomic context

See RER1 in Genome Data Viewer
Location:
1p36.32
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (2391841..2405436)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (2323214..2336883)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 12294 Neighboring gene SKI proto-oncogene Neighboring gene MORN repeat containing 1 Neighboring gene small nuclear ribonucleoprotein polypeptide N pseudogene Neighboring gene Sharpr-MPRA regulatory region 13804 Neighboring gene peroxisomal biogenesis factor 10 Neighboring gene phospholipase C eta 2 Neighboring gene pantothenate kinase 4 (inactive)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with retention in endoplasmic reticulum 1 homolog (RER1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
acetylcholine receptor binding IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
positive regulation of protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
protein retention in ER lumen IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
retrograde vesicle-mediated transport, Golgi to ER IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
retrograde vesicle-mediated transport, Golgi to ER IDA
Inferred from Direct Assay
more info
PubMed 
skeletal muscle acetylcholine-gated channel clustering IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
cell surface IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum-Golgi intermediate compartment IEA
Inferred from Electronic Annotation
more info
 
integral component of Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein RER1
Names
RER1 retention in endoplasmic reticulum 1 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016128.1 RefSeqGene

    Range
    5067..18662
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_007033.5NP_008964.3  protein RER1

    See identical proteins and their annotated locations for NP_008964.3

    Status: REVIEWED

    Source sequence(s)
    AL513477, BC004965, BM682824, DA409924
    Consensus CDS
    CCDS41232.1
    UniProtKB/Swiss-Prot
    O15258
    UniProtKB/TrEMBL
    Q5T094
    Related
    ENSP00000475168.1, ENST00000605895.6
    Conserved Domains (1) summary
    pfam03248
    Location:20184
    Rer1; Rer1 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    2391841..2405436
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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