Format

Send to:

Choose Destination

DUSP14 dual specificity phosphatase 14 [ Homo sapiens (human) ]

Gene ID: 11072, updated on 13-Mar-2020

Summary

Official Symbol
DUSP14provided by HGNC
Official Full Name
dual specificity phosphatase 14provided by HGNC
Primary source
HGNC:HGNC:17007
See related
Ensembl:ENSG00000276023 MIM:606618
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MKP6; MKP-L
Summary
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
Expression
Broad expression in thyroid (RPKM 9.3), skin (RPKM 8.7) and 24 other tissues See more
Orthologs

Genomic context

See DUSP14 in Genome Data Viewer
Location:
17q12
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (37488561..37513501)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (35849951..35873603)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene acetyl-CoA carboxylase alpha Neighboring gene chromosome 17 open reading frame 78 Neighboring gene transcriptional adaptor 2A Neighboring gene ribosomal protein L24 pseudogene Neighboring gene synergin gamma Neighboring gene microRNA 378j Neighboring gene DExD-box helicase 52

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.
NHGRI GWA Catalog
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
MAP kinase tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
inactivation of MAPK activity IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dual specificity protein phosphatase 14
Names
MAP kinase phosphatase 6
MKP-1-like protein tyrosine phosphatase
MKP-6
mitogen-activated protein kinase phosphatase 6
NP_008957.1
XP_005257034.1
XP_011522536.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007026.4NP_008957.1  dual specificity protein phosphatase 14

    See identical proteins and their annotated locations for NP_008957.1

    Status: VALIDATED

    Source sequence(s)
    AC243585, AC243654
    Consensus CDS
    CCDS11320.1
    UniProtKB/Swiss-Prot
    O95147
    UniProtKB/TrEMBL
    Q6FI36
    Related
    ENSP00000478595.1, ENST00000617516.5
    Conserved Domains (1) summary
    cd00127
    Location:26162
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    37488561..37513501
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524234.1XP_011522536.1  dual specificity protein phosphatase 14 isoform X1

    See identical proteins and their annotated locations for XP_011522536.1

    UniProtKB/Swiss-Prot
    O95147
    UniProtKB/TrEMBL
    Q6FI36
    Conserved Domains (1) summary
    cd00127
    Location:26162
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  2. XM_005256977.3XP_005257034.1  dual specificity protein phosphatase 14 isoform X1

    See identical proteins and their annotated locations for XP_005257034.1

    UniProtKB/Swiss-Prot
    O95147
    UniProtKB/TrEMBL
    Q6FI36
    Related
    ENSP00000484091.1, ENST00000613659.1
    Conserved Domains (1) summary
    cd00127
    Location:26162
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    1729062..1752665
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center