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Dusp14 dual specificity phosphatase 14 [ Mus musculus (house mouse) ]

Gene ID: 56405, updated on 9-May-2024

Summary

Official Symbol
Dusp14provided by MGI
Official Full Name
dual specificity phosphatase 14provided by MGI
Primary source
MGI:MGI:1927168
See related
Ensembl:ENSMUSG00000018648 AllianceGenome:MGI:1927168
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mkp6; MKP-L; D11Ertd395e; 1110014C10Rik; 2310042C07Rik
Summary
Predicted to enable phosphoprotein phosphatase activity. Predicted to be involved in protein dephosphorylation. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human DUSP14 (dual specificity phosphatase 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 19.6), frontal lobe adult (RPKM 14.7) and 21 other tissues See more
Orthologs
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Genomic context

See Dusp14 in Genome Data Viewer
Location:
11 C; 11 51.29 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (83938859..83960016, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (84048033..84069256, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5256 Neighboring gene STARR-positive B cell enhancer ABC_E11769 Neighboring gene DExD box helicase 52 Neighboring gene synergin, gamma Neighboring gene STARR-positive B cell enhancer mm9_chr11:83845520-83845821 Neighboring gene STARR-seq mESC enhancer starr_30212 Neighboring gene transcriptional adaptor 2A Neighboring gene acetyl-Coenzyme A carboxylase alpha Neighboring gene predicted gene 11437

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5)  1 citation
  • Gene trapped (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MAP kinase tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
dual specificity protein phosphatase 14
Names
MAP kinase phosphatase 6
MAP kinase phsophatase 6
Mkp-1 like protein tyrosine phosphatase
mitogen-activated protein kinase phosphatase 6
NP_001395670.1
NP_001395671.1
NP_001395672.1
NP_001395673.1
NP_001395674.1
NP_001395675.1
NP_062793.2
XP_036012759.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001408741.1NP_001395670.1  dual specificity protein phosphatase 14

    Status: VALIDATED

    Source sequence(s)
    AL645615
    UniProtKB/Swiss-Prot
    Q9D715, Q9JLY7
    UniProtKB/TrEMBL
    Q542U4
    Related
    ENSMUSP00000103736.2, ENSMUST00000108101.8
  2. NM_001408742.1NP_001395671.1  dual specificity protein phosphatase 14

    Status: VALIDATED

    Source sequence(s)
    AL645615
    UniProtKB/Swiss-Prot
    Q9D715, Q9JLY7
    UniProtKB/TrEMBL
    Q542U4
  3. NM_001408743.1NP_001395672.1  dual specificity protein phosphatase 14

    Status: VALIDATED

    Source sequence(s)
    AL645615
    UniProtKB/Swiss-Prot
    Q9D715, Q9JLY7
    UniProtKB/TrEMBL
    Q542U4
    Related
    ENSMUSP00000130624.2, ENSMUST00000164891.8
  4. NM_001408744.1NP_001395673.1  dual specificity protein phosphatase 14

    Status: VALIDATED

    Source sequence(s)
    AL645615
    UniProtKB/Swiss-Prot
    Q9D715, Q9JLY7
    UniProtKB/TrEMBL
    Q542U4
    Related
    ENSMUSP00000018792.6, ENSMUST00000018792.12
  5. NM_001408745.1NP_001395674.1  dual specificity protein phosphatase 14

    Status: VALIDATED

    Source sequence(s)
    AL645615
    UniProtKB/Swiss-Prot
    Q9D715, Q9JLY7
    UniProtKB/TrEMBL
    Q542U4
  6. NM_001408746.1NP_001395675.1  dual specificity protein phosphatase 14

    Status: VALIDATED

    Source sequence(s)
    AL645615
    UniProtKB/Swiss-Prot
    Q9D715, Q9JLY7
    UniProtKB/TrEMBL
    Q542U4
  7. NM_019819.4NP_062793.2  dual specificity protein phosphatase 14

    See identical proteins and their annotated locations for NP_062793.2

    Status: VALIDATED

    Source sequence(s)
    AL645615
    Consensus CDS
    CCDS25182.1
    UniProtKB/Swiss-Prot
    Q9D715, Q9JLY7
    UniProtKB/TrEMBL
    Q542U4, Q7TPY1
    Related
    ENSMUSP00000098271.5, ENSMUST00000100705.11
    Conserved Domains (1) summary
    cd14572
    Location:20169
    DUSP14; dual specificity protein phosphatase 14

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    83938859..83960016 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156866.1XP_036012759.1  dual specificity protein phosphatase 14 isoform X1

    UniProtKB/Swiss-Prot
    Q9D715, Q9JLY7
    UniProtKB/TrEMBL
    Q542U4, Q7TPY1
    Conserved Domains (1) summary
    cd14572
    Location:20169
    DUSP14; dual specificity protein phosphatase 14