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UBE2C ubiquitin conjugating enzyme E2 C [ Homo sapiens (human) ]

Gene ID: 11065, updated on 12-Jan-2019

Summary

Official Symbol
UBE2Cprovided by HGNC
Official Full Name
ubiquitin conjugating enzyme E2 Cprovided by HGNC
Primary source
HGNC:HGNC:15937
See related
Ensembl:ENSG00000175063 MIM:605574
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UBCH10; dJ447F3.2
Summary
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been defined on chromosomes 4, 14, 15, 18, and 19. [provided by RefSeq, Aug 2013]
Expression
Biased expression in bone marrow (RPKM 14.3), lymph node (RPKM 11.0) and 13 other tissues See more
Orthologs

Genomic context

See UBE2C in Genome Data Viewer
Location:
20q13.12
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (45812576..45816957)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (44441255..44445596)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene WAP four-disulfide core domain 3 Neighboring gene RNA, U6atac small nuclear 38, pseudogene Neighboring gene deoxynucleotidyltransferase terminal interacting protein 1 Neighboring gene troponin C2, fast skeletal type Neighboring gene sorting nexin family member 21 Neighboring gene acyl-CoA thioesterase 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ubiquitin-conjugating enzyme E2C (UBE2C) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin conjugating enzyme activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-like protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
anaphase-promoting complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ubiquitin-conjugating enzyme E2 C
Names
(E3-independent) E2 ubiquitin-conjugating enzyme C
E2 ubiquitin-conjugating enzyme C
cyclin-selective ubiquitin carrier protein
mitotic-specific ubiquitin-conjugating enzyme
ubiquitin conjugating enzyme E2C
ubiquitin-protein ligase C
NP_001268670.1
NP_001268671.1
NP_008950.1
NP_861515.1
NP_861516.1
NP_861517.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281741.1NP_001268670.1  ubiquitin-conjugating enzyme E2 C isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has multiple differences in the central coding region but maintains the reading frame, compared to variant 1. The encoded isoform (6) is shorter, compared to isoform 1.
    Source sequence(s)
    BC007656, BU171488, DB062573
    Consensus CDS
    CCDS74734.1
    UniProtKB/Swiss-Prot
    O00762
    UniProtKB/TrEMBL
    A0A087WVK1
    Related
    ENSP00000479486.1, ENST00000617055.4
    Conserved Domains (1) summary
    cl00154
    Location:92123
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  2. NM_001281742.1NP_001268671.1  ubiquitin-conjugating enzyme E2 C isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks an exon in central coding region, which results in a translational frameshift, compared to variant 1. The encoded isoform (7) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC007656, CN354813, DB062573
    Consensus CDS
    CCDS74733.1
    UniProtKB/Swiss-Prot
    O00762
    UniProtKB/TrEMBL
    A0A0A0MSE8
    Related
    ENSP00000385878.2, ENST00000405520.5
    Conserved Domains (1) summary
    cl00154
    Location:3372
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  3. NM_007019.4NP_008950.1  ubiquitin-conjugating enzyme E2 C isoform 1

    See identical proteins and their annotated locations for NP_008950.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC007656, DB062573
    Consensus CDS
    CCDS13370.1
    UniProtKB/Swiss-Prot
    O00762
    UniProtKB/TrEMBL
    Q5TZN3
    Related
    ENSP00000348838.4, ENST00000356455.8
    Conserved Domains (1) summary
    pfam00179
    Location:34170
    UQ_con; Ubiquitin-conjugating enzyme
  4. NM_181799.2NP_861515.1  ubiquitin-conjugating enzyme E2 C isoform 2

    See identical proteins and their annotated locations for NP_861515.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    BC007656, BU169315, DB062573
    Consensus CDS
    CCDS13371.1
    UniProtKB/Swiss-Prot
    O00762
    Related
    ENSP00000335674.3, ENST00000335046.7
    Conserved Domains (1) summary
    cl00154
    Location:33152
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  5. NM_181800.2NP_861516.1  ubiquitin-conjugating enzyme E2 C isoform 3

    See identical proteins and their annotated locations for NP_861516.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
    Source sequence(s)
    BC007656, CK904708, DB062573
    Consensus CDS
    CCDS13372.1
    UniProtKB/Swiss-Prot
    O00762
    Related
    ENSP00000333975.5, ENST00000352551.9
    Conserved Domains (1) summary
    pfam00179
    Location:44141
    UQ_con; Ubiquitin-conjugating enzyme
  6. NM_181801.3NP_861517.1  ubiquitin-conjugating enzyme E2 C isoform 4

    See identical proteins and their annotated locations for NP_861517.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an alternate 5'-terminal exon and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    BC007656, BI858659, BP227692
    Consensus CDS
    CCDS13374.1
    UniProtKB/Swiss-Prot
    O00762
    Related
    ENSP00000361649.4, ENST00000372568.4
    Conserved Domains (1) summary
    pfam00179
    Location:1131
    UQ_con; Ubiquitin-conjugating enzyme

RNA

  1. NR_104036.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks two internal exons, as compared to variant 1. This variant is represented as non-coding because it lacks a significant portion of the coding region and does not encode a supported protein.
    Source sequence(s)
    BC007656, CB143441, DB062573
    Related
    ENST00000243893.10
  2. NR_104037.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) uses two alternate splice sites in internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC007656, CN354815, DB062573

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

    Range
    45812576..45816957
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_181802.1: Suppressed sequence

    Description
    NM_181802.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
  2. NM_181803.1: Suppressed sequence

    Description
    NM_181803.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
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