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Ube2c ubiquitin-conjugating enzyme E2C [ Mus musculus (house mouse) ]

Gene ID: 68612, updated on 5-Mar-2024

Summary

Official Symbol
Ube2cprovided by MGI
Official Full Name
ubiquitin-conjugating enzyme E2Cprovided by MGI
Primary source
MGI:MGI:1915862
See related
Ensembl:ENSMUSG00000001403 AllianceGenome:MGI:1915862
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D2Ertd695e; 1110015A16Rik
Summary
Predicted to enable ubiquitin conjugating enzyme activity and ubiquitin-like protein ligase binding activity. Predicted to be involved in several processes, including anaphase-promoting complex-dependent catabolic process; protein polyubiquitination; and regulation of mitotic cell cycle phase transition. Predicted to act upstream of or within cell division. Predicted to be located in cytosol and plasma membrane. Predicted to be part of anaphase-promoting complex. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; pancreas epithelium; spleen; and submandibular gland. Orthologous to human UBE2C (ubiquitin conjugating enzyme E2 C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14.5 (RPKM 259.5), liver E14 (RPKM 226.5) and 15 other tissues See more
Orthologs
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Genomic context

See Ube2c in Genome Data Viewer
Location:
2 H3; 2 85.27 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164611849..164614822)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164769929..164772902)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene WAP four-disulfide core domain 3 Neighboring gene deoxynucleotidyltransferase, terminal, interacting protein 1 Neighboring gene STARR-seq mESC enhancer starr_06333 Neighboring gene STARR-positive B cell enhancer ABC_E417 Neighboring gene troponin C2, fast Neighboring gene sorting nexin family member 21 Neighboring gene acyl-CoA thioesterase 8

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin conjugating enzyme activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-like protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in anaphase-promoting complex-dependent catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in exit from mitosis ISO
Inferred from Sequence Orthology
more info
 
involved_in free ubiquitin chain polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of exit from mitosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitotic metaphase/anaphase transition ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitotic metaphase/anaphase transition IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of anaphase-promoting complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ubiquitin-conjugating enzyme E2 C
Names
(E3-independent) E2 ubiquitin-conjugating enzyme C
E2 ubiquitin-conjugating enzyme C
ubcH10
ubiquitin carrier protein C
ubiquitin-protein ligase C
NP_081061.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026785.2NP_081061.1  ubiquitin-conjugating enzyme E2 C

    See identical proteins and their annotated locations for NP_081061.1

    Status: PROVISIONAL

    Source sequence(s)
    AK003722
    Consensus CDS
    CCDS17055.1
    UniProtKB/Swiss-Prot
    Q3TUJ0, Q9D1C1
    UniProtKB/TrEMBL
    A2A4Z0, Q3UWQ1
    Related
    ENSMUSP00000085581.7, ENSMUST00000088248.13
    Conserved Domains (1) summary
    pfam00179
    Location:34170
    UQ_con; Ubiquitin-conjugating enzyme

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    164611849..164614822
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)