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WWP2 WW domain containing E3 ubiquitin protein ligase 2 [ Homo sapiens (human) ]

Gene ID: 11060, updated on 29-Mar-2020

Summary

Official Symbol
WWP2provided by HGNC
Official Full Name
WW domain containing E3 ubiquitin protein ligase 2provided by HGNC
Primary source
HGNC:HGNC:16804
See related
Ensembl:ENSG00000198373 MIM:602308
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AIP2; WWp2-like
Summary
This gene encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 10. [provided by RefSeq, Jul 2012]
Expression
Ubiquitous expression in lung (RPKM 8.8), spleen (RPKM 8.4) and 25 other tissues See more
Orthologs

Genomic context

See WWP2 in Genome Data Viewer
Location:
16q22.1
Exon count:
30
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (69762301..69941741)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (69796187..69975644)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene NIN1 (RPN12) binding protein 1 homolog Neighboring gene non-POU domain containing, octamer-binding pseudogene 1 Neighboring gene nuclear pore complex-interacting protein Neighboring gene microRNA 140 Neighboring gene C-type lectin domain family 18 member A Neighboring gene nuclear pore complex interacting protein family member B14, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations.
NHGRI GWA Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase II transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
RNA polymerase II transcription factor binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase activity TAS
Traceable Author Statement
more info
 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
cellular protein modification process TAS
Traceable Author Statement
more info
PubMed 
extracellular transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of Notch signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein K63-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein K63-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
protein autoubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
regulation of membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
regulation of potassium ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
viral entry into host cell TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
membrane HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin ligase complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
NEDD4-like E3 ubiquitin-protein ligase WWP2
Names
HECT-type E3 ubiquitin transferase WWP2
atrophin-1 interacting protein 2
NP_001257382.1
NP_001257383.1
NP_001257384.1
NP_008945.2
NP_955456.1
XP_011521125.1
XP_011521127.1
XP_011521128.1
XP_016878368.1
XP_016878369.1
XP_016878370.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270453.1NP_001257382.1  NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform 4

    See identical proteins and their annotated locations for NP_001257382.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK300266, AK316097, BQ183829, JN712744
    Consensus CDS
    CCDS58476.1
    UniProtKB/Swiss-Prot
    O00308
    UniProtKB/TrEMBL
    B4DHF6
    Related
    ENSP00000348283.3, ENST00000356003.6
    Conserved Domains (5) summary
    smart00119
    Location:423751
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:400752
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:331361
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:216245
    WW; WW domain
    cl14603
    Location:126
    C2; C2 domain
  2. NM_001270454.2NP_001257383.1  NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform WWP2-FL

    See identical proteins and their annotated locations for NP_001257383.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1 and 5 encode the same isoform (WWP2-FL).
    Source sequence(s)
    JN712744
    Consensus CDS
    CCDS10885.1
    UniProtKB/Swiss-Prot
    O00308
    UniProtKB/TrEMBL
    A0A024R711
    Related
    ENSP00000352069.2, ENST00000359154.6
    Conserved Domains (5) summary
    cd04021
    Location:17142
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    cd00078
    Location:516868
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:447477
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:332361
    WW; WW domain
    cl26464
    Location:164343
    Atrophin-1; Atrophin-1 family
  3. NM_001270455.2NP_001257384.1  NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform WWP2-N

    See identical proteins and their annotated locations for NP_001257384.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 3' UTR, compared to variant 1. The encoded isoform (WWP2-N) has a shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AC026468, BC000108, DC402912
    Consensus CDS
    CCDS58475.1
    UniProtKB/Swiss-Prot
    O00308
    Related
    ENSP00000455311.1, ENST00000569174.5
    Conserved Domains (3) summary
    cd04021
    Location:17142
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    pfam00397
    Location:302331
    WW; WW domain
    cl27169
    Location:189308
    ZipA; ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic ...
  4. NM_007014.5NP_008945.2  NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform WWP2-FL

    See identical proteins and their annotated locations for NP_008945.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (WWP2-FL). Variants 1 and 5 encode the same isoform.
    Source sequence(s)
    DC402912, JN712744, U96114
    Consensus CDS
    CCDS10885.1
    UniProtKB/Swiss-Prot
    O00308
    UniProtKB/TrEMBL
    A0A024R711
    Conserved Domains (5) summary
    cd04021
    Location:17142
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    cd00078
    Location:516868
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:447477
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:332361
    WW; WW domain
    cl26464
    Location:164343
    Atrophin-1; Atrophin-1 family
  5. NM_199424.3NP_955456.1  NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform WWP2-C

    See identical proteins and their annotated locations for NP_955456.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a large portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (WWP2-C) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK126332, AK316097, JN712744
    Consensus CDS
    CCDS58477.1
    UniProtKB/Swiss-Prot
    O00308
    UniProtKB/TrEMBL
    B4DHF6
    Related
    ENSP00000456216.1, ENST00000568684.1
    Conserved Domains (3) summary
    smart00119
    Location:100428
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:77429
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:838
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    69762301..69941741
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022879.1XP_016878368.1  NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1

    UniProtKB/Swiss-Prot
    O00308
    UniProtKB/TrEMBL
    A0A024R711
    Conserved Domains (5) summary
    cd04021
    Location:17142
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    cd00078
    Location:516868
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:447477
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:332361
    WW; WW domain
    cl26464
    Location:164343
    Atrophin-1; Atrophin-1 family
  2. XM_017022881.1XP_016878370.1  NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1

    UniProtKB/Swiss-Prot
    O00308
    UniProtKB/TrEMBL
    A0A024R711
    Conserved Domains (5) summary
    cd04021
    Location:17142
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    cd00078
    Location:516868
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:447477
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:332361
    WW; WW domain
    cl26464
    Location:164343
    Atrophin-1; Atrophin-1 family
  3. XM_011522823.2XP_011521125.1  NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1

    See identical proteins and their annotated locations for XP_011521125.1

    UniProtKB/Swiss-Prot
    O00308
    UniProtKB/TrEMBL
    A0A024R711
    Conserved Domains (5) summary
    cd04021
    Location:17142
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    cd00078
    Location:516868
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:447477
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:332361
    WW; WW domain
    cl26464
    Location:164343
    Atrophin-1; Atrophin-1 family
  4. XM_011522825.1XP_011521127.1  NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1

    See identical proteins and their annotated locations for XP_011521127.1

    UniProtKB/Swiss-Prot
    O00308
    UniProtKB/TrEMBL
    A0A024R711
    Conserved Domains (5) summary
    cd04021
    Location:17142
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    cd00078
    Location:516868
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:447477
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:332361
    WW; WW domain
    cl26464
    Location:164343
    Atrophin-1; Atrophin-1 family
  5. XM_017022880.1XP_016878369.1  NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1

    UniProtKB/Swiss-Prot
    O00308
    UniProtKB/TrEMBL
    A0A024R711
    Conserved Domains (5) summary
    cd04021
    Location:17142
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    cd00078
    Location:516868
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:447477
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:332361
    WW; WW domain
    cl26464
    Location:164343
    Atrophin-1; Atrophin-1 family
  6. XM_011522826.3XP_011521128.1  NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X2

    See identical proteins and their annotated locations for XP_011521128.1

    UniProtKB/Swiss-Prot
    O00308
    Conserved Domains (5) summary
    smart00119
    Location:423751
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:400752
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:331361
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:216245
    WW; WW domain
    cl14603
    Location:126
    C2; C2 domain
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