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Wwp2 WW domain containing E3 ubiquitin protein ligase 2 [ Mus musculus (house mouse) ]

Gene ID: 66894, updated on 8-Feb-2024

Summary

Official Symbol
Wwp2provided by MGI
Official Full Name
WW domain containing E3 ubiquitin protein ligase 2provided by MGI
Primary source
MGI:MGI:1914144
See related
Ensembl:ENSMUSG00000031930 AllianceGenome:MGI:1914144
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AIP2; 1300010O06Rik
Summary
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and ubiquitin protein ligase activity. Involved in cellular protein metabolic process and regulation of transcription, DNA-templated. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including heart valve; respiratory system; sensory organ; skeleton; and tarsus. Orthologous to human WWP2 (WW domain containing E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 69.1), testis adult (RPKM 34.2) and 28 other tissues See more
Orthologs
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Genomic context

See Wwp2 in Genome Data Viewer
Location:
8 D3; 8 54.15 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (108162966..108285922)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (107436334..107559290)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22601 Neighboring gene NAD(P)H dehydrogenase, quinone 1 Neighboring gene STARR-positive B cell enhancer ABC_E8262 Neighboring gene STARR-positive B cell enhancer ABC_E1107 Neighboring gene NIN1/RPN12 binding protein 1 homolog Neighboring gene STARR-seq mESC enhancer starr_22606 Neighboring gene ribosomal protein S26, pseudogene 1 Neighboring gene predicted gene, 39241 Neighboring gene STARR-seq mESC enhancer starr_22610 Neighboring gene predicted gene, 51547 Neighboring gene STARR-positive B cell enhancer ABC_E11397 Neighboring gene microRNA 140 Neighboring gene STARR-seq mESC enhancer starr_22613 Neighboring gene STARR-seq mESC enhancer starr_22614 Neighboring gene STARR-seq mESC enhancer starr_22615 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 Neighboring gene STARR-seq mESC enhancer starr_22616 Neighboring gene predicted gene 8940

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in extracellular transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transporter activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K63-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein K63-linked ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein ubiquitination ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of monoatomic ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of potassium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
NEDD4-like E3 ubiquitin-protein ligase WWP2
Names
HECT-type E3 ubiquitin transferase WWP2
WW domain-containing protein 2
WW domain-containing protein 4
NP_080106.1
XP_006531362.1
XP_006531364.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025830.4NP_080106.1  NEDD4-like E3 ubiquitin-protein ligase WWP2

    See identical proteins and their annotated locations for NP_080106.1

    Status: VALIDATED

    Source sequence(s)
    AC132126
    Consensus CDS
    CCDS40467.1
    UniProtKB/Swiss-Prot
    Q8BTG4, Q923F6, Q9DBH0
    UniProtKB/TrEMBL
    A0A1D5RM92, I3RSH5
    Related
    ENSMUSP00000132224.2, ENSMUST00000166615.3
    Conserved Domains (5) summary
    cd04021
    Location:17142
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    PRK07003
    Location:149299
    PRK07003; DNA polymerase III subunit gamma/tau
    cd00078
    Location:516868
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:447477
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:332361
    WW; WW domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    108162966..108285922
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531299.5XP_006531362.1  NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1

    See identical proteins and their annotated locations for XP_006531362.1

    UniProtKB/Swiss-Prot
    Q8BTG4, Q923F6, Q9DBH0
    UniProtKB/TrEMBL
    A0A1D5RM92, I3RSH5
    Related
    ENSMUSP00000148679.2, ENSMUST00000212205.2
    Conserved Domains (5) summary
    cd04021
    Location:17142
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    PRK07003
    Location:149299
    PRK07003; DNA polymerase III subunit gamma/tau
    cd00078
    Location:516868
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:447477
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:332361
    WW; WW domain
  2. XM_006531301.2XP_006531364.1  NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X2

    See identical proteins and their annotated locations for XP_006531364.1

    UniProtKB/TrEMBL
    Q3TXI7
    Related
    ENSMUSP00000148813.2, ENSMUST00000212543.2
    Conserved Domains (2) summary
    cd00078
    Location:77429
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:838
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

RNA

  1. XR_003947327.1 RNA Sequence