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DSTN destrin, actin depolymerizing factor [ Homo sapiens (human) ]

Gene ID: 11034, updated on 5-Aug-2018

Summary

Official Symbol
DSTNprovided by HGNC
Official Full Name
destrin, actin depolymerizing factorprovided by HGNC
Primary source
HGNC:HGNC:15750
See related
Ensembl:ENSG00000125868 MIM:609114; Vega:OTTHUMG00000031947
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADF; ACTDP; HEL32; bA462D18.2
Summary
The product of this gene belongs to the actin-binding proteins ADF family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in prostate (RPKM 293.6), esophagus (RPKM 273.4) and 25 other tissues See more
Orthologs

Genomic context

See DSTN in Genome Data Viewer
Location:
20p12.1
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (17569173..17608242)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (17549818..17588887)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene proprotein convertase subtilisin/kexin type 2 Neighboring gene dynein light chain Tctex-type 3 pseudogene 1 Neighboring gene beaded filament structural protein 1 Neighboring gene ribosomal protein S27a pseudogene 2 Neighboring gene ras homolog family member G pseudogene Neighboring gene RNA, 7SK small nuclear pseudogene 69 Neighboring gene ribosome binding protein 1 Neighboring gene uncharacterized LOC105372547 Neighboring gene barrier to autointegration factor 2

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Genes, including GABRP, ADF, HINT, PRSS2, SDCBP, PTK9, PPP2R5B, ITGA3, PRKCBP1, HMOX2, HAT1, PPP1cB, and ICAM-1, are upregulated after treatment of human astrocytes with HIV-1 gp120 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Androgen receptor signaling pathway, organism-specific biosystem (from WikiPathways)
    Androgen receptor signaling pathway, organism-specific biosystemAndrogens, mainly testosterone and 5alpha-dihydrotestosterone (DHT) play significant role in the growth and development of the male reproductive organs. These steroid hormones bring about their biolo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin filament depolymerization IDA
Inferred from Direct Assay
more info
PubMed 
actin filament fragmentation IEA
Inferred from Electronic Annotation
more info
 
actin filament severing IEA
Inferred from Electronic Annotation
more info
 
actin polymerization or depolymerization TAS
Traceable Author Statement
more info
PubMed 
positive regulation of actin filament depolymerization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
actin cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
cortical actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 

General protein information

Preferred Names
destrin
Names
actin-depolymerizing factor
bA462D18.2 (destrin (actin depolymerizing factor ADF) (ACTDP))
epididymis luminal protein 32

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011546.1NP_001011546.1  destrin isoform b

    See identical proteins and their annotated locations for NP_001011546.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an additional segment in the coding region compared to variant 1. This difference causes translation initiation at a downstream ATG and an isoform (b) with a shorter N-terminus compared to an isoform a.
    Source sequence(s)
    AI597935, BC009477, BX647319, CN482756, S65738
    Consensus CDS
    CCDS46580.1
    UniProtKB/Swiss-Prot
    P60981
    Related
    ENSP00000476975.1, OTTHUMP00000274072, ENST00000474024.5, OTTHUMT00000101970
    Conserved Domains (1) summary
    smart00102
    Location:2136
    ADF; Actin depolymerisation factor/cofilin -like domains
  2. NM_006870.3NP_006861.1  destrin isoform a

    See identical proteins and their annotated locations for NP_006861.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript, but encodes the longer isoform (a).
    Source sequence(s)
    AI597935, BC009477, CN482756, S65738
    Consensus CDS
    CCDS13127.1
    UniProtKB/Swiss-Prot
    P60981
    UniProtKB/TrEMBL
    V9HWA6
    Related
    ENSP00000246069.6, OTTHUMP00000030335, ENST00000246069.11, OTTHUMT00000078131
    Conserved Domains (1) summary
    cd11286
    Location:3152
    ADF_cofilin_like; Cofilin, Destrin, and related actin depolymerizing factors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

    Range
    17569173..17608242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529144.1XP_011527446.1  destrin isoform X1

    See identical proteins and their annotated locations for XP_011527446.1

    UniProtKB/Swiss-Prot
    P60981
    Conserved Domains (1) summary
    smart00102
    Location:2136
    ADF; Actin depolymerisation factor/cofilin -like domains
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