U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dstn destrin [ Mus musculus (house mouse) ]

Gene ID: 56431, updated on 12-May-2024

Summary

Official Symbol
Dstnprovided by MGI
Official Full Name
destrinprovided by MGI
Primary source
MGI:MGI:1929270
See related
Ensembl:ENSMUSG00000015932 AllianceGenome:MGI:1929270
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ADF; Dsn; corn1; sid23p; 2610043P17Rik
Summary
Enables actin filament binding activity. Involved in actin filament fragmentation. Acts upstream of or within positive regulation of actin filament depolymerization. Located in cortical actin cytoskeleton. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human DSTN (destrin, actin depolymerizing factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 498.8), large intestine adult (RPKM 115.0) and 14 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Dstn in Genome Data Viewer
Location:
2 G1; 2 70.89 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (143757251..143785244)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (143915331..143943324)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene beaded filament structural protein 1, in lens-CP94 Neighboring gene predicted gene, 33648 Neighboring gene predicted gene 11686 Neighboring gene STARR-seq mESC enhancer starr_05893 Neighboring gene STARR-positive B cell enhancer ABC_E9072 Neighboring gene STARR-seq mESC enhancer starr_05895 Neighboring gene predicted gene, 33804 Neighboring gene predicted gene, 54119 Neighboring gene STARR-seq mESC enhancer starr_05899 Neighboring gene ribosome binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E513 Neighboring gene STARR-positive B cell enhancer ABC_E2050 Neighboring gene STARR-seq mESC enhancer starr_05901 Neighboring gene BANF family member 2 Neighboring gene barrier to autointegration factor 2, opposite strand

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cortical actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
destrin
Names
actin-depolymerizing factor
corneal disease 1
sid 23

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019771.2NP_062745.1  destrin

    See identical proteins and their annotated locations for NP_062745.1

    Status: VALIDATED

    Source sequence(s)
    AB025406, BF123977
    Consensus CDS
    CCDS16812.1
    UniProtKB/Swiss-Prot
    Q9R0P5
    UniProtKB/TrEMBL
    Q4FK36
    Related
    ENSMUSP00000099461.4, ENSMUST00000103172.4
    Conserved Domains (1) summary
    cd11286
    Location:3152
    ADF_cofilin_like; Cofilin, Destrin, and related actin depolymerizing factors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    143757251..143785244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)