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ADAP1 ArfGAP with dual PH domains 1 [ Homo sapiens (human) ]

Gene ID: 11033, updated on 15-Dec-2018

Summary

Official Symbol
ADAP1provided by HGNC
Official Full Name
ArfGAP with dual PH domains 1provided by HGNC
Primary source
HGNC:HGNC:16486
See related
Ensembl:ENSG00000105963 MIM:608114
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GCS1L; CENTA1; p42IP4
Expression
Broad expression in brain (RPKM 18.4), colon (RPKM 17.8) and 18 other tissues See more
Orthologs

Genomic context

See ADAP1 in Genome Data Viewer
Location:
7p22.3
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (897900..955407, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (937537..995208, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene Sad1 and UNC84 domain containing 1 Neighboring gene golgi to ER traffic protein 4 Neighboring gene cytochrome c oxidase assembly factor COX19 Neighboring gene chromosome 7 open reading frame 50 Neighboring gene cytochrome P450 family 2 subfamily W member 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: COX19

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
inositol 1,3,4,5 tetrakisphosphate binding TAS
Traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol bisphosphate binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-3,4,5-trisphosphate binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
arf-GAP with dual PH domain-containing protein 1
Names
centaurin-alpha
centaurin-alpha-1
cnt-a1
putative MAPK-activating protein PM25

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284308.1NP_001271237.1  arf-GAP with dual PH domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001271237.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon and initiates translation from an alternate upstream start codon compared to variant 1. The resulting longer isoform (2) has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AI910700, AK300999, BC033747
    Consensus CDS
    CCDS64577.1
    UniProtKB/Swiss-Prot
    O75689
    Related
    ENSP00000442682.1, ENST00000539900.5
    Conserved Domains (4) summary
    smart00105
    Location:28137
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd01251
    Location:263368
    PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2
    cd13252
    Location:141249
    PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1
    pfam00169
    Location:266366
    PH; PH domain
  2. NM_001284309.1NP_001271238.1  arf-GAP with dual PH domain-containing protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001271238.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon and initiates translation from an in-frame downstream start codon compared to variant 1. The resulting isoform (3) has a shorter N-terminus compared to isoform 1. Variants 3 and 4 encode the same isoform.
    Source sequence(s)
    AI910700, BC033747, DA872042
    Consensus CDS
    CCDS64576.1
    UniProtKB/Swiss-Prot
    O75689
    UniProtKB/TrEMBL
    A8K3A2
    Related
    ENSP00000481154.1, ENST00000611167.4
    Conserved Domains (3) summary
    cd01251
    Location:180285
    PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2
    cd13252
    Location:58166
    PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1
    cl27571
    Location:154
    ArfGap; Putative GTPase activating protein for Arf
  3. NM_001284310.1NP_001271239.1  arf-GAP with dual PH domain-containing protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001271239.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon at the 5' end and contains an alternate 5' terminal exon, which results in translation initiation from an in-frame downstream start codon compared to variant 1. The resulting isoform (3) has a shorter N-terminus compared to isoform 1. Variants 3 and 4 encode the same isoform.
    Source sequence(s)
    AI910700, AK092471, BC033747
    Consensus CDS
    CCDS64576.1
    UniProtKB/Swiss-Prot
    O75689
    UniProtKB/TrEMBL
    A8K3A2
    Related
    ENSP00000407267.2, ENST00000449296.6
    Conserved Domains (3) summary
    cd01251
    Location:180285
    PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2
    cd13252
    Location:58166
    PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1
    cl27571
    Location:154
    ArfGap; Putative GTPase activating protein for Arf
  4. NM_001284311.1NP_001271240.1  arf-GAP with dual PH domain-containing protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001271240.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks 2 exons at the 5' end and contains an alternate 5' terminal exon, which results in translation initiation from an alternate start codon compared to variant 1. The resulting shorter isoform (4) has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AI910700, AK300859, BC033747, BM837987
    Consensus CDS
    CCDS75558.1
    UniProtKB/Swiss-Prot
    O75689
    UniProtKB/TrEMBL
    B4DUZ7
    Related
    ENSP00000478011.1, ENST00000617043.4
    Conserved Domains (4) summary
    cd01251
    Location:157262
    PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2
    cd13252
    Location:35143
    PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1
    pfam00169
    Location:160260
    PH; PH domain
    cl02464
    Location:831
    ArfGap; Putative GTPase activating protein for Arf
  5. NM_006869.4NP_006860.2  arf-GAP with dual PH domain-containing protein 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1.
    Source sequence(s)
    AC073957
    Consensus CDS
    CCDS5318.1
    Related
    ENSP00000265846.5, ENST00000265846.9
    Conserved Domains (3) summary
    smart00105
    Location:10126
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd01251
    Location:252357
    PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2
    cd13252
    Location:130238
    PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    897900..955407 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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