Adap1 ArfGAP with dual PH domains 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adap1provided by MGI
Official Full Name: ArfGAP with dual PH domains 1provided by MGI
Primary source: MGI:MGI:2442201
See related: Ensembl:ENSMUSG00000056413 AllianceGenome:MGI:2442201
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GC1L; Centa1; p42IP4; 4930431P11Rik
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in regulation of GTPase activity. Predicted to be located in cytosol and nucleus. Predicted to be active in intracellular membrane-bounded organelle and plasma membrane. Is expressed in nervous system. Orthologous to human ADAP1 (ArfGAP with dual PH domains 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in duodenum adult (RPKM 78.3), large intestine adult (RPKM 65.2) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5; 5 G2

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (139257631..139311516, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (139271876..139325763, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ADAP1/Centaurin-alpha1 Negatively Regulates Dendritic Spine Function and Memory Formation in the Hippocampus.
Title: ADAP1/Centaurin-α1 Negatively Regulates Dendritic Spine Function and Memory Formation in the Hippocampus.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (3) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:491818

NoName (e-PCR)
- UniSTS:224251

Homology

Homologs of the Adap1 gene: The Adap1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, mosquito, and frog.
Orthologs from Annotation Pipeline: 333 organisms have orthologs with human gene Adap1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of GTPase activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: arf-GAP with dual PH domain-containing protein 1

Names: centaurin, alpha 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172723.4 → NP_766311.2 arf-GAP with dual PH domain-containing protein 1

Status: VALIDATED

Source sequence(s)

BC079634, BY740716, CX242691

Consensus CDS

CCDS19806.2

UniProtKB/TrEMBL

E9PY16

Related

ENSMUSP00000106489.2, ENSMUST00000110865.2

Conserved Domains (3) summary

smart00105
Location:10 → 126

ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

cd01251
Location:252 → 357

PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2

cd13252
Location:130 → 238

PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

139257631..139311516 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006504669.4 → XP_006504732.1 arf-GAP with dual PH domain-containing protein 1 isoform X1

See identical proteins and their annotated locations for XP_006504732.1

UniProtKB/TrEMBL

Q8BVR8

Conserved Domains (3) summary

cd01251
Location:180 → 285

PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2

cd13252
Location:58 → 166

PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1

cl28907
Location:1 → 41

ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)