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COX19 cytochrome c oxidase assembly factor COX19 [ Homo sapiens (human) ]

Gene ID: 90639, updated on 4-Jun-2020

Summary

Official Symbol
COX19provided by HGNC
Official Full Name
cytochrome c oxidase assembly factor COX19provided by HGNC
Primary source
HGNC:HGNC:28074
See related
Ensembl:ENSG00000240230 MIM:610429
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
COX19 encodes a cytochrome c oxidase (COX)-assembly protein. The S. cerevisiae Cox19 protein may play a role in metal transport to the mitochondrial intermembrane space and assembly of complex IV of the mitochondrial respiratory chain (Sacconi et al., 2005 [PubMed 16212937]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in skin (RPKM 2.7), duodenum (RPKM 2.6) and 25 other tissues See more
Orthologs

Genomic context

See COX19 in Genome Data Viewer
Location:
7p22.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (964852..975549, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (1004486..1015235, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene guided entry of tail-anchored proteins factor 4 Neighboring gene ArfGAP with dual PH domains 1 Neighboring gene chromosome 7 open reading frame 50 Neighboring gene cytochrome P450 family 2 subfamily W member 1 Neighboring gene microRNA 339

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: ADAP1

Homology

Clone Names

  • MGC104475

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular copper ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrial respiratory chain complex IV assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial intermembrane space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cytochrome c oxidase assembly protein COX19
Names
COX19 cytochrome c oxidase assembly homolog
COX19, cytochrome c oxidase assembly factor
cytochrome c oxidase assembly homolog 19
hCOX19

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031617.3NP_001026788.1  cytochrome c oxidase assembly protein COX19

    See identical proteins and their annotated locations for NP_001026788.1

    Status: VALIDATED

    Source sequence(s)
    AA437231, AC073957, AY957566
    Consensus CDS
    CCDS34582.1
    UniProtKB/Swiss-Prot
    Q49B96
    Related
    ENSP00000342015.3, ENST00000344111.4
    Conserved Domains (1) summary
    pfam06747
    Location:3064
    CHCH; CHCH domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    964852..975549 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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