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RBPMS RNA binding protein, mRNA processing factor [ Homo sapiens (human) ]

Gene ID: 11030, updated on 11-Jun-2021

Summary

Official Symbol
RBPMSprovided by HGNC
Official Full Name
RNA binding protein, mRNA processing factorprovided by HGNC
Primary source
HGNC:HGNC:19097
See related
Ensembl:ENSG00000157110 MIM:601558
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HERMES
Summary
This gene encodes a member of the RNA recognition motif family of RNA-binding proteins. The RNA recognition motif is between 80-100 amino acids in length and family members contain one to four copies of the motif. The RNA recognition motif consists of two short stretches of conserved sequence, as well as a few highly conserved hydrophobic residues. The encoded protein has a single, putative RNA recognition motif in its N-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]
Expression
Ubiquitous expression in prostate (RPKM 14.5), ovary (RPKM 13.7) and 23 other tissues See more
Orthologs
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Genomic context

See RBPMS in Genome Data Viewer
Location:
8p12
Exon count:
20
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (30384541..30572261)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (30242057..30429773)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase A pseudogene 84 Neighboring gene tubulin beta pseudogene 1 Neighboring gene RBPMS antisense RNA 1 Neighboring gene heart enhancer 24 Neighboring gene uncharacterized LOC112268025 Neighboring gene Sharpr-MPRA regulatory region 2547 Neighboring gene uncharacterized LOC112268024 Neighboring gene general transcription factor IIE subunit 2 Neighboring gene RNA, U5A small nuclear 3, pseudogene Neighboring gene small integral membrane protein 18 Neighboring gene glutathione-disulfide reductase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Heritability of submaximal exercise heart rate response to exercise training is accounted for by nine SNPs.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32971

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables poly(A) binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in P-body IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
RNA-binding protein with multiple splicing
Names
RNA binding protein with multiple splicing
heart and RRM expressed sequence

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029534.1 RefSeqGene

    Range
    5114..192830
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001008710.3NP_001008710.1  RNA-binding protein with multiple splicing isoform A

    See identical proteins and their annotated locations for NP_001008710.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform A. Variants 1 and 4 encode the same isoform.
    Source sequence(s)
    BC003608, BX097929, CN360712, CX165198, CX781149, D84107
    Consensus CDS
    CCDS6077.1
    UniProtKB/Swiss-Prot
    Q93062
    Related
    ENSP00000380486.4, ENST00000397323.9
    Conserved Domains (2) summary
    TIGR01628
    Location:64165
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12682
    Location:2398
    RRM_RBPMS; RNA recognition motif (RRM) found in vertebrate RNA-binding protein with multiple splicing (RBP-MS)
  2. NM_001008711.3NP_001008711.1  RNA-binding protein with multiple splicing isoform B

    See identical proteins and their annotated locations for NP_001008711.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate exon in the 3' coding region which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (B) has a longer and distinct C-terminus, compared to isoform A.
    Source sequence(s)
    BC003608, BX097929, CN360712, CX165198, CX781149, D84108
    Consensus CDS
    CCDS34875.1
    UniProtKB/Swiss-Prot
    Q93062
    Related
    ENSP00000287771.5, ENST00000287771.9
    Conserved Domains (2) summary
    cd12682
    Location:2398
    RRM_RBPMS; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing (RBP-MS)
    cl25887
    Location:26200
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  3. NM_001008712.3NP_001008712.1  RNA-binding protein with multiple splicing isoform C

    See identical proteins and their annotated locations for NP_001008712.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks several exons and its 3'-terminal exon extends past a splice site that is used in variant 1. The encoded isoform (C) has a longer and distinct C-terminus, compared to isoform A.
    Source sequence(s)
    AI025136, BC003608, CX165198
    Consensus CDS
    CCDS34876.1
    UniProtKB/Swiss-Prot
    Q93062
    Related
    ENSP00000340176.4, ENST00000339877.8
    Conserved Domains (2) summary
    TIGR01628
    Location:64187
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12682
    Location:2398
    RRM_RBPMS; RNA recognition motif (RRM) found in vertebrate RNA-binding protein with multiple splicing (RBP-MS)
  4. NM_006867.4NP_006858.1  RNA-binding protein with multiple splicing isoform A

    See identical proteins and their annotated locations for NP_006858.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) includes an alternate exon in the 3' UTR compared to variant 1. Variants 1 and 4 encode the same isoform (A).
    Source sequence(s)
    BC003608, BX097929, CA425568, CN360712, CX165198, CX781149, D84107
    Consensus CDS
    CCDS6077.1
    UniProtKB/Swiss-Prot
    Q93062
    Related
    ENSP00000318102.4, ENST00000320203.8
    Conserved Domains (2) summary
    TIGR01628
    Location:64165
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12682
    Location:2398
    RRM_RBPMS; RNA recognition motif (RRM) found in vertebrate RNA-binding protein with multiple splicing (RBP-MS)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    30384541..30572261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012987.2XP_016868476.1  RNA-binding protein with multiple splicing isoform X9

  2. XM_017012981.2XP_016868470.1  RNA-binding protein with multiple splicing isoform X2

  3. XM_017012986.2XP_016868475.1  RNA-binding protein with multiple splicing isoform X8

    UniProtKB/Swiss-Prot
    Q93062
    Conserved Domains (2) summary
    TIGR01628
    Location:64165
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12682
    Location:2398
    RRM_RBPMS; RNA recognition motif (RRM) found in vertebrate RNA-binding protein with multiple splicing (RBP-MS)
  4. XM_017012982.2XP_016868471.1  RNA-binding protein with multiple splicing isoform X3

    Conserved Domains (1) summary
    cd12682
    Location:2398
    RRM_RBPMS; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing (RBP-MS)
  5. XM_024447054.1XP_024302822.1  RNA-binding protein with multiple splicing isoform X6

    Conserved Domains (2) summary
    cl17169
    Location:1440
    RRM_SF; RNA recognition motif (RRM) superfamily
    cl27087
    Location:40131
    SPOR; Sporulation related domain
  6. XM_017012990.2XP_016868479.1  RNA-binding protein with multiple splicing isoform X12

  7. XM_017012980.2XP_016868469.1  RNA-binding protein with multiple splicing isoform X1

  8. XM_017012989.2XP_016868478.1  RNA-binding protein with multiple splicing isoform X11

    Conserved Domains (1) summary
    cl17169
    Location:2398
    RRM_SF; RNA recognition motif (RRM) superfamily
  9. XM_017012988.2XP_016868477.1  RNA-binding protein with multiple splicing isoform X10

    UniProtKB/TrEMBL
    D3DSV0
    Conserved Domains (2) summary
    TIGR01628
    Location:64165
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cl17169
    Location:2398
    RRM_SF; RNA recognition motif (RRM) superfamily
  10. XM_017012992.2XP_016868481.1  RNA-binding protein with multiple splicing isoform X15

    Conserved Domains (1) summary
    cd12682
    Location:2398
    RRM_RBPMS; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing (RBP-MS)
  11. XM_017012984.2XP_016868473.1  RNA-binding protein with multiple splicing isoform X5

    UniProtKB/TrEMBL
    B4E3T4
    Related
    ENSP00000428675.1, ENST00000517860.5
    Conserved Domains (1) summary
    cd12682
    Location:2398
    RRM_RBPMS; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing (RBP-MS)
  12. XM_017012991.2XP_016868480.1  RNA-binding protein with multiple splicing isoform X13

  13. XM_017012983.2XP_016868472.1  RNA-binding protein with multiple splicing isoform X4

  14. XM_024447055.1XP_024302823.1  RNA-binding protein with multiple splicing isoform X14

    Conserved Domains (1) summary
    cl17169
    Location:538
    RRM_SF; RNA recognition motif (RRM) superfamily
  15. XM_017012985.2XP_016868474.1  RNA-binding protein with multiple splicing isoform X7

RNA

  1. XR_001745460.2 RNA Sequence

  2. XR_001745462.2 RNA Sequence

  3. XR_001745463.2 RNA Sequence

  4. XR_001745461.2 RNA Sequence

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