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Rbpms RNA binding protein gene with multiple splicing [ Mus musculus (house mouse) ]

Gene ID: 19663, updated on 26-Sep-2022

Summary

Official Symbol
Rbpmsprovided by MGI
Official Full Name
RNA binding protein gene with multiple splicingprovided by MGI
Primary source
MGI:MGI:1334446
See related
Ensembl:ENSMUSG00000031586 AllianceGenome:MGI:1334446
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RBP-MS; hermes; 2010300K22Rik; 2700019M19Rik
Summary
Predicted to enable RNA binding activity; protein homodimerization activity; and transcription coactivator activity. Predicted to be involved in positive regulation of SMAD protein signal transduction; positive regulation of pathway-restricted SMAD protein phosphorylation; and response to oxidative stress. Predicted to be located in cytoplasmic stress granule; cytosol; and nucleoplasm. Is expressed in several structures, including central nervous system; gut; heart; retina; and urinary system. Orthologous to human RBPMS (RNA binding protein, mRNA processing factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 24.2), bladder adult (RPKM 22.5) and 20 other tissues See more
Orthologs
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Genomic context

See Rbpms in Genome Data Viewer
Location:
8; 8 A4
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (34272671..34419925, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (33782643..33929922, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700104B16 gene Neighboring gene general transcription factor II E, polypeptide 2 (beta subunit) Neighboring gene small integral membrane protein 18 Neighboring gene VISTA enhancer mm70 Neighboring gene predicted gene, 51528 Neighboring gene predicted gene, 33588 Neighboring gene small nucleolar RNA SNORA29 Neighboring gene predicted gene, 39157

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables poly(A) binding ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
RNA-binding protein with multiple splicing
Names
HEart, RRM Expressed Sequence
RNA-binding protein with multiple splicing (RBP-MS)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042674.2NP_001036139.1  RNA-binding protein with multiple splicing isoform 1

    See identical proteins and their annotated locations for NP_001036139.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR, compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AC162523, AK003434, AK041118
    Consensus CDS
    CCDS40317.1
    UniProtKB/Swiss-Prot
    Q9CPU5, Q9WVB0
    UniProtKB/TrEMBL
    A0A6P5Q5W7, A0A8C6N2B6
    Related
    ENSMUSP00000055813.5, ENSMUST00000053251.12
    Conserved Domains (1) summary
    cd12682
    Location:2398
    RRM_RBPMS; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing (RBP-MS)
  2. NM_001042675.2NP_001036140.1  RNA-binding protein with multiple splicing isoform 3

    See identical proteins and their annotated locations for NP_001036140.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 3 which is longer and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC162523, AK012265
    Consensus CDS
    CCDS40318.1
    UniProtKB/Swiss-Prot
    Q9WVB0
    UniProtKB/TrEMBL
    A0A6P5Q6G5, A0A8C6I5J1
    Related
    ENSMUSP00000033995.7, ENSMUST00000033995.14
    Conserved Domains (1) summary
    cd12682
    Location:2398
    RRM_RBPMS; RNA recognition motif (RRM) found in vertebrate RNA-binding protein with multiple splicing (RBP-MS)
  3. NM_001286168.1NP_001273097.1  RNA-binding protein with multiple splicing isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. This results in a shorter protein (isoform 4) with a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC162523, AK003434, AK079238
    Consensus CDS
    CCDS72112.1
    UniProtKB/TrEMBL
    Q8C586, T1ECW4
    Related
    ENSMUSP00000033994.9, ENSMUST00000033994.15
    Conserved Domains (1) summary
    cd12682
    Location:2398
    RRM_RBPMS; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing (RBP-MS)
  4. NM_019733.3NP_062707.1  RNA-binding protein with multiple splicing isoform 1

    See identical proteins and their annotated locations for NP_062707.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC162523, AK003434, AK041118, AK079238
    Consensus CDS
    CCDS40317.1
    UniProtKB/Swiss-Prot
    Q9CPU5, Q9WVB0
    UniProtKB/TrEMBL
    A0A6P5Q5W7, A0A8C6N2B6, Q8C586
    Related
    ENSMUSP00000140387.2, ENSMUST00000191473.7
    Conserved Domains (1) summary
    cd12682
    Location:2398
    RRM_RBPMS; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing (RBP-MS)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    34272671..34419925 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509037.4XP_006509100.3  RNA-binding protein with multiple splicing isoform X4

    Conserved Domains (1) summary
    cd12682
    Location:40115
    RRM_RBPMS; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing (RBP-MS)
  2. XM_006509035.5XP_006509098.1  RNA-binding protein with multiple splicing isoform X2

    Conserved Domains (1) summary
    cd12682
    Location:2398
    RRM_RBPMS; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing (RBP-MS)
  3. XM_006509034.5XP_006509097.1  RNA-binding protein with multiple splicing isoform X1

    Conserved Domains (1) summary
    cd12682
    Location:40115
    RRM_RBPMS; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing (RBP-MS)
  4. XM_036153838.1XP_036009731.1  RNA-binding protein with multiple splicing isoform X3

    Conserved Domains (1) summary
    cd12682
    Location:40115
    RRM_RBPMS; RNA recognition motif (RRM) found in vertebrate RNA-binding protein with multiple splicing (RBP-MS)

RNA

  1. XR_378783.4 RNA Sequence

  2. XR_378781.4 RNA Sequence

  3. XR_378782.3 RNA Sequence

  4. XR_378780.3 RNA Sequence