Format

Send to:

Choose Destination

KIF2C kinesin family member 2C [ Homo sapiens (human) ]

Gene ID: 11004, updated on 4-Oct-2020

Summary

Official Symbol
KIF2Cprovided by HGNC
Official Full Name
kinesin family member 2Cprovided by HGNC
Primary source
HGNC:HGNC:6393
See related
Ensembl:ENSG00000142945 MIM:604538
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCAK; CT139; KNSL6
Summary
This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Expression
Biased expression in testis (RPKM 39.1), bone marrow (RPKM 9.5) and 6 other tissues See more
Orthologs

Genomic context

See KIF2C in Genome Data Viewer
Location:
1p34.1
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (44739704..44767767)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (45205396..45233439)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene armadillo like helical domain containing 1 Neighboring gene uncharacterized LOC105378690 Neighboring gene RNA, U5F small nuclear 1 Neighboring gene RNA, U5D small nuclear 1 Neighboring gene small nucleolar RNA, C/D box 160 Neighboring gene small nucleolar RNA, C/D box 55 Neighboring gene small nucleolar RNA, C/D box 46 Neighboring gene ribosomal protein S8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat The DNA repair gene DNA-PKcs and cell cycle-related genes Cdc20, Cdc25C, KIF2C and CTS1 are downregulated in HIV-1 Tat-expressing human rhabdomyosarcoma cells PubMed
Vpr vpr HIV-1 Vpr upregulates KIF2C in HeLa cells within 12 hours of exposure PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centromeric DNA binding TAS
Traceable Author Statement
more info
PubMed 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule plus-end binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
condensed chromosome kinetochore IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with cytoplasmic microtubule ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
microtubule plus-end IDA
Inferred from Direct Assay
more info
PubMed 
microtubule plus-end TAS
Traceable Author Statement
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
spindle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
kinesin-like protein KIF2C
Names
kinesin-like protein 6
mitotic centromere-associated kinesin
testis tissue sperm-binding protein Li 68n

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297655.2NP_001284584.1  kinesin-like protein KIF2C isoform 2

    See identical proteins and their annotated locations for NP_001284584.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB264115, AK300756, BU615368
    UniProtKB/Swiss-Prot
    Q99661
    UniProtKB/TrEMBL
    B7Z6Q6
    Conserved Domains (2) summary
    cd01367
    Location:217545
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
    pfam00225
    Location:223546
    Kinesin; Kinesin motor domain
  2. NM_001297656.2NP_001284585.1  kinesin-like protein KIF2C isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as tsMCAK) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AK302267, AY026505, BC014924, BU615368, DC404550
    Consensus CDS
    CCDS72774.1
    UniProtKB/Swiss-Prot
    Q99661
    UniProtKB/TrEMBL
    B7Z7M6
    Related
    ENSP00000361291.1, ENST00000372217.5
    Conserved Domains (2) summary
    cd01367
    Location:204532
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
    pfam00225
    Location:210533
    Kinesin; Kinesin motor domain
  3. NM_001297657.2NP_001284586.1  kinesin-like protein KIF2C isoform 4

    See identical proteins and their annotated locations for NP_001284586.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AK302267, BC014924, BU615368, DC399082
    UniProtKB/Swiss-Prot
    Q99661
    UniProtKB/TrEMBL
    B7Z7M6
    Conserved Domains (2) summary
    cd01367
    Location:145473
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
    pfam00225
    Location:151474
    Kinesin; Kinesin motor domain
  4. NM_006845.4NP_006836.2  kinesin-like protein KIF2C isoform 1

    See identical proteins and their annotated locations for NP_006836.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AU130795, BC008764, BC014924, BU615368
    Consensus CDS
    CCDS512.1
    UniProtKB/Swiss-Prot
    Q99661
    UniProtKB/TrEMBL
    A0A140VKF1
    Related
    ENSP00000361298.4, ENST00000372224.9
    Conserved Domains (1) summary
    cd01367
    Location:258586
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    44739704..44767767
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540540.2XP_011538842.1  kinesin-like protein KIF2C isoform X1

    See identical proteins and their annotated locations for XP_011538842.1

    UniProtKB/TrEMBL
    B7Z7M6
    Conserved Domains (2) summary
    cd01367
    Location:145473
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
    pfam00225
    Location:151474
    Kinesin; Kinesin motor domain
  2. XM_011540541.2XP_011538843.1  kinesin-like protein KIF2C isoform X1

    See identical proteins and their annotated locations for XP_011538843.1

    UniProtKB/TrEMBL
    B7Z7M6
    Conserved Domains (2) summary
    cd01367
    Location:145473
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
    pfam00225
    Location:151474
    Kinesin; Kinesin motor domain
Support Center