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Kif2c kinesin family member 2C [ Mus musculus (house mouse) ]

Gene ID: 73804, updated on 1-Mar-2024

Summary

Official Symbol
Kif2cprovided by MGI
Official Full Name
kinesin family member 2Cprovided by MGI
Primary source
MGI:MGI:1921054
See related
Ensembl:ENSMUSG00000028678 AllianceGenome:MGI:1921054
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MCAK; ESTM5; Knsl6; 4930402F02Rik
Summary
Predicted to enable ATP hydrolysis activity; microtubule motor activity; and microtubule plus-end binding activity. Predicted to be involved in several processes, including attachment of mitotic spindle microtubules to kinetochore; microtubule cytoskeleton organization; and regulation of chromosome segregation. Predicted to act upstream of or within cell division and chromosome segregation. Located in chromosome, centromeric region. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and sensory organ. Orthologous to human KIF2C (kinesin family member 2C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 63.2), CNS E11.5 (RPKM 19.8) and 8 other tissues See more
Orthologs
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Genomic context

See Kif2c in Genome Data Viewer
Location:
4 D1; 4 53.42 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (117016830..117039821, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (117159633..117182624, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3505 Neighboring gene predicted gene, 26330 Neighboring gene small nucleolar RNA, C/D box 55 Neighboring gene ribosomal protein S8 Neighboring gene STARR-positive B cell enhancer ABC_E4651 Neighboring gene STARR-positive B cell enhancer ABC_E662 Neighboring gene predicted gene, 25099 Neighboring gene STARR-positive B cell enhancer ABC_E1279 Neighboring gene predicted gene, 23143

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC11883

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
 
enables microtubule plus-end binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chromosome segregation IEA
Inferred from Electronic Annotation
more info
 
involved_in establishment or maintenance of microtubule cytoskeleton polarity ISO
Inferred from Sequence Orthology
more info
 
involved_in metaphase chromosome alignment ISO
Inferred from Sequence Orthology
more info
 
involved_in microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic metaphase chromosome alignment ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of chromosome segregation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with kinetochore ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule plus-end ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
kinesin-like protein KIF2C
Names
kinesin-like 6
mitotic centromere-associated kinesin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290662.1NP_001277591.1  kinesin-like protein KIF2C isoform 2

    See identical proteins and their annotated locations for NP_001277591.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 2, which has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK161309, AL671866
    Consensus CDS
    CCDS71452.1
    UniProtKB/TrEMBL
    Q3TTL2, Q8BU22
    Conserved Domains (1) summary
    cd01367
    Location:203531
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
  2. NM_134471.4NP_608301.3  kinesin-like protein KIF2C isoform 1

    See identical proteins and their annotated locations for NP_608301.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK150222, AK161309, CF163926, CK381255, CO798410
    Consensus CDS
    CCDS18531.1
    UniProtKB/Swiss-Prot
    A2AE71, Q922S8
    UniProtKB/TrEMBL
    Q8BU22
    Related
    ENSMUSP00000064261.3, ENSMUST00000065896.9
    Conserved Domains (2) summary
    cd01367
    Location:254582
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
    pfam00225
    Location:260583
    Kinesin; Kinesin motor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    117016830..117039821 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240621.2XP_011238923.1  kinesin-like protein KIF2C isoform X1

    See identical proteins and their annotated locations for XP_011238923.1

    UniProtKB/TrEMBL
    Q8BU22
    Conserved Domains (1) summary
    cd01367
    Location:206534
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
  2. XM_006503435.4XP_006503498.1  kinesin-like protein KIF2C isoform X2

    See identical proteins and their annotated locations for XP_006503498.1

    UniProtKB/TrEMBL
    Q3TTL2, Q8BU22
    Conserved Domains (1) summary
    cd01367
    Location:203531
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
  3. XM_017320411.2XP_017175900.1  kinesin-like protein KIF2C isoform X1

    UniProtKB/TrEMBL
    Q8BU22
    Conserved Domains (1) summary
    cd01367
    Location:206534
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
  4. XM_030253838.2XP_030109698.1  kinesin-like protein KIF2C isoform X2

    UniProtKB/TrEMBL
    Q3TTL2, Q8BU22
    Conserved Domains (1) summary
    cd01367
    Location:203531
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
  5. XM_011240620.3XP_011238922.1  kinesin-like protein KIF2C isoform X1

    See identical proteins and their annotated locations for XP_011238922.1

    UniProtKB/TrEMBL
    Q8BU22
    Conserved Domains (1) summary
    cd01367
    Location:206534
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
  6. XM_011240622.3XP_011238924.1  kinesin-like protein KIF2C isoform X2

    See identical proteins and their annotated locations for XP_011238924.1

    UniProtKB/TrEMBL
    Q3TTL2, Q8BU22
    Related
    ENSMUSP00000102044.2, ENSMUST00000106436.8
    Conserved Domains (1) summary
    cd01367
    Location:203531
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
  7. XM_006503433.3XP_006503496.1  kinesin-like protein KIF2C isoform X1

    See identical proteins and their annotated locations for XP_006503496.1

    UniProtKB/TrEMBL
    Q8BU22
    Conserved Domains (1) summary
    cd01367
    Location:206534
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group