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Kif2c kinesin family member 2C [ Mus musculus (house mouse) ]

Gene ID: 73804, updated on 2-Nov-2024

Summary

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Official Symbol
Kif2cprovided by MGI
Official Full Name
kinesin family member 2Cprovided by MGI
Primary source
MGI:MGI:1921054
See related
Ensembl:ENSMUSG00000028678 AllianceGenome:MGI:1921054
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MCAK; ESTM5; Knsl6; 4930402F02Rik
Summary
Predicted to enable ATP hydrolysis activity; microtubule motor activity; and microtubule plus-end binding activity. Involved in postsynaptic cytoskeleton organization and regulation of neurotransmitter receptor localization to postsynaptic specialization membrane. Located in chromosome, centromeric region. Is active in glutamatergic synapse; postsynapse; and presynapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human KIF2C (kinesin family member 2C). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 63.2), CNS E11.5 (RPKM 19.8) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Kif2c in Genome Data Viewer
Location:
4 D1; 4 53.42 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (117016830..117039821, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (117159633..117182624, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3505 Neighboring gene predicted gene, 26330 Neighboring gene small nucleolar RNA, C/D box 55 Neighboring gene ribosomal protein S8 Neighboring gene STARR-positive B cell enhancer ABC_E4651 Neighboring gene STARR-positive B cell enhancer ABC_E662 Neighboring gene predicted gene, 25099 Neighboring gene STARR-positive B cell enhancer ABC_E1279 Neighboring gene predicted gene, 23143

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. KIF2C regulates synaptic plasticity and cognition in mice through dynamic microtubule depolymerization. Zheng R, et al. Elife, 2022 Feb 9. PMID 35138249, Free PMC Article
  2. MCAK regulates chromosome alignment but is not necessary for preventing aneuploidy in mouse oocyte meiosis I. Illingworth C, et al. Development, 2010 Jul. PMID 20504960, Free PMC Article
  3. Effects of the KIF2C neck peptide on microtubules: lateral disintegration of microtubules and β-structure formation. Shimizu Y, et al. FEBS J, 2013 Apr. PMID 23398918
  4. A perikinetochoric ring defined by MCAK and Aurora-B as a novel centromere domain. Parra MT, et al. PLoS Genet, 2006 Jun 2. PMID 16741559, Free PMC Article
  5. MCAK is present at centromeres, midspindle and chiasmata and involved in silencing of the spindle assembly checkpoint in mammalian oocytes. Vogt E, et al. Mol Hum Reprod, 2010 Sep. PMID 20406800

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ablation of KIF2C in Purkinje cells impairs metabotropic glutamate receptor trafficking and motor coordination in male mice.
    Title: Ablation of KIF2C in Purkinje cells impairs metabotropic glutamate receptor trafficking and motor coordination in male mice.
  2. KIF2C regulates synaptic plasticity and cognition in mice through dynamic microtubule depolymerization.
    Title: KIF2C regulates synaptic plasticity and cognition in mice through dynamic microtubule depolymerization.
  3. Clathrin's adaptor interaction sites are repurposed to stabilize microtubules during mitosis.
    Title: Clathrin's adaptor interaction sites are repurposed to stabilize microtubules during mitosis.
  4. PAK1 phosphorylates MCAK and regulates both its localization and function.
    Title: Signaling-dependent phosphorylation of mitotic centromere-associated kinesin regulates microtubule depolymerization and its centrosomal localization.
  5. MCAK appears to possess a unique distribution and function in oocyte maturation.
    Title: MCAK is present at centromeres, midspindle and chiasmata and involved in silencing of the spindle assembly checkpoint in mammalian oocytes.
  6. MCAK contributes to chromosome alignment in meiosis I, but is not necessary for preventing chromosome segregation errors.
    Title: MCAK regulates chromosome alignment but is not necessary for preventing aneuploidy in mouse oocyte meiosis I.
  7. Shugoshin 2 is necessary for the loading of MCAK at the inner centromere, but is dispensable for the loading of the outer kinetochore proteins BubR1 and CENP-E.
    Title: Sequential assembly of centromeric proteins in male mouse meiosis.
  8. Possible functions of MCAK at the inner centromere domain and at the perikinetochoric ring during both meiotic divisions.
    Title: A perikinetochoric ring defined by MCAK and Aurora-B as a novel centromere domain.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1)  1 citation
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC11883

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
enables microtubule plus-end binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule plus-end binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
  
involved_in attachment of mitotic spindle microtubules to kinetochore ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment or maintenance of microtubule cytoskeleton polarity IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment or maintenance of microtubule cytoskeleton polarity ISO
Inferred from Sequence Orthology
more info
  
involved_in metaphase chromosome alignment ISO
Inferred from Sequence Orthology
more info
  
involved_in metaphase chromosome alignment ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in microtubule depolymerization IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic metaphase chromosome alignment ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic metaphase chromosome alignment ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in postsynaptic cytoskeleton organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in postsynaptic cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with cytoplasmic microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule plus-end ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule plus-end ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynapse IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynapse IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kinesin-like protein KIF2C
Names
kinesin-like 6
mitotic centromere-associated kinesin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290662.1 → NP_001277591.1  kinesin-like protein KIF2C isoform 2

    See identical proteins and their annotated locations for NP_001277591.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 2, which has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK161309, AL671866
    Consensus CDS
    CCDS71452.1
    UniProtKB/TrEMBL
    Q3TTL2, Q8BU22
    Conserved Domains (1) summary
    cd01367
    Location:203 → 531
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group

  2. NM_134471.4 → NP_608301.3  kinesin-like protein KIF2C isoform 1

    See identical proteins and their annotated locations for NP_608301.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK150222, AK161309, CF163926, CK381255, CO798410
    Consensus CDS
    CCDS18531.1
    UniProtKB/Swiss-Prot
    A2AE71, Q922S8
    UniProtKB/TrEMBL
    Q8BU22
    Related
    ENSMUSP00000064261.3, ENSMUST00000065896.9
    Conserved Domains (2) summary
    cd01367
    Location:254 → 582
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
    pfam00225
    Location:260 → 583
    Kinesin; Kinesin motor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    117016830..117039821 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240621.2 → XP_011238923.1  kinesin-like protein KIF2C isoform X1

    See identical proteins and their annotated locations for XP_011238923.1

    UniProtKB/TrEMBL
    Q8BU22
    Conserved Domains (1) summary
    cd01367
    Location:206 → 534
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group

  2. XM_006503435.4 → XP_006503498.1  kinesin-like protein KIF2C isoform X2

    See identical proteins and their annotated locations for XP_006503498.1

    UniProtKB/TrEMBL
    Q3TTL2, Q8BU22
    Conserved Domains (1) summary
    cd01367
    Location:203 → 531
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group

  3. XM_017320411.2 → XP_017175900.1  kinesin-like protein KIF2C isoform X1

    UniProtKB/TrEMBL
    Q8BU22
    Conserved Domains (1) summary
    cd01367
    Location:206 → 534
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group

  4. XM_030253838.2 → XP_030109698.1  kinesin-like protein KIF2C isoform X2

    UniProtKB/TrEMBL
    Q3TTL2, Q8BU22
    Conserved Domains (1) summary
    cd01367
    Location:203 → 531
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group

  5. XM_011240620.3 → XP_011238922.1  kinesin-like protein KIF2C isoform X1

    See identical proteins and their annotated locations for XP_011238922.1

    UniProtKB/TrEMBL
    Q8BU22
    Conserved Domains (1) summary
    cd01367
    Location:206 → 534
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group

  6. XM_011240622.3 → XP_011238924.1  kinesin-like protein KIF2C isoform X2

    See identical proteins and their annotated locations for XP_011238924.1

    UniProtKB/TrEMBL
    Q3TTL2, Q8BU22
    Related
    ENSMUSP00000102044.2, ENSMUST00000106436.8
    Conserved Domains (1) summary
    cd01367
    Location:203 → 531
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group

  7. XM_006503433.3 → XP_006503496.1  kinesin-like protein KIF2C isoform X1

    See identical proteins and their annotated locations for XP_006503496.1

    UniProtKB/TrEMBL
    Q8BU22
    Conserved Domains (1) summary
    cd01367
    Location:206 → 534
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q922S8.1 GenPept UniProtKB/Swiss-Prot:Q922S8

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