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Arrb1 arrestin, beta 1 [ Mus musculus (house mouse) ]

Gene ID: 109689, updated on 9-Mar-2023

Summary

Official Symbol
Arrb1provided by MGI
Official Full Name
arrestin, beta 1provided by MGI
Primary source
MGI:MGI:99473
See related
Ensembl:ENSMUSG00000018909 AllianceGenome:MGI:99473
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1200006I17Rik; G430100A01Rik
Summary
Enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process and mitogen-activated protein kinase kinase binding activity. Involved in several processes, including negative regulation of Notch signaling pathway; positive regulation of cell communication; and regulation of cellular protein metabolic process. Acts upstream of or within phototransduction and regulation of G protein-coupled receptor signaling pathway. Located in cytosol and pseudopodium. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver; and respiratory system. Orthologous to human ARRB1 (arrestin beta 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14.5 (RPKM 46.5), liver E14 (RPKM 43.8) and 27 other tissues See more
Orthologs
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Genomic context

See Arrb1 in Genome Data Viewer
Location:
7 E1; 7 54.09 cM
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (99184356..99255979)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (99535147..99606772)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39056 Neighboring gene predicted gene, 40450 Neighboring gene predicted gene, 34172 Neighboring gene microRNA 326 Neighboring gene trophoblast glycoprotein-like Neighboring gene predicted gene, 53384

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC124269, MGC124270

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables AP-2 adaptor complex binding ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables V2 vasopressin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables alpha-1A adrenergic receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables alpha-1B adrenergic receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables angiotensin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables arrestin family protein binding ISO
Inferred from Sequence Orthology
more info
 
enables clathrin adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables clathrin binding ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables follicle-stimulating hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables insulin-like growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables mitogen-activated protein kinase kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphorylated amino acid binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in G protein-coupled receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in follicle-stimulating hormone signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within phototransduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of histone acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in visual perception IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in pseudopodium IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
beta-arrestin-1
Names
beta-arrestin1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177231.2NP_796205.1  beta-arrestin-1 isoform A

    See identical proteins and their annotated locations for NP_796205.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (a) represents the longer transcript and encodes the longer protein (isoform A).
    Source sequence(s)
    AK147508, AK147566
    Consensus CDS
    CCDS40032.1
    UniProtKB/Swiss-Prot
    Q8BTJ5, Q8BWG8
    UniProtKB/TrEMBL
    A0A8C6I8T4
    Related
    ENSMUSP00000095866.3, ENSMUST00000098266.9
    Conserved Domains (2) summary
    smart01017
    Location:193356
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:18174
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  2. NM_178220.3NP_835738.1  beta-arrestin-1 isoform B

    See identical proteins and their annotated locations for NP_835738.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (b) lacks an alternate exon in the 3' coding region compared to variant a. The resulting protein (isoform B) is shorter but has the same N- and C-termini compared to isoform A.
    Source sequence(s)
    AK090090, AK147508, AK147566
    Consensus CDS
    CCDS21484.1
    UniProtKB/Swiss-Prot
    Q8BWG8
    UniProtKB/TrEMBL
    A0A8C6IAU3
    Related
    ENSMUSP00000032995.9, ENSMUST00000032995.15
    Conserved Domains (2) summary
    smart01017
    Location:193348
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:18174
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    99184356..99255979
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507198.5XP_006507261.1  beta-arrestin-1 isoform X1

    Conserved Domains (2) summary
    smart01017
    Location:230393
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:55211
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  2. XM_006507199.5XP_006507262.1  beta-arrestin-1 isoform X2

    Conserved Domains (2) summary
    smart01017
    Location:230385
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:55211
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  3. XM_006507200.3XP_006507263.1  beta-arrestin-1 isoform X5

    Conserved Domains (2) summary
    smart01017
    Location:188351
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:13169
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  4. XM_036152569.1XP_036008462.1  beta-arrestin-1 isoform X4

    Conserved Domains (2) summary
    smart01017
    Location:188343
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:13169
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  5. XM_011241644.3XP_011239946.1  beta-arrestin-1 isoform X3

    UniProtKB/TrEMBL
    A0A8C6IAY8
    Conserved Domains (2) summary
    smart01017
    Location:205368
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:30186
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RNA

  1. XR_003946373.2 RNA Sequence

  2. XR_378207.5 RNA Sequence

  3. XR_378208.5 RNA Sequence

  4. XR_003946374.1 RNA Sequence

  5. XR_003946372.2 RNA Sequence