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ARRB1 arrestin beta 1 [ Homo sapiens (human) ]

Gene ID: 408, updated on 13-Mar-2020

Summary

Official Symbol
ARRB1provided by HGNC
Official Full Name
arrestin beta 1provided by HGNC
Primary source
HGNC:HGNC:711
See related
Ensembl:ENSG00000137486 MIM:107940
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARB1; ARR1
Summary
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011]
Expression
Broad expression in brain (RPKM 24.0), lung (RPKM 19.9) and 24 other tissues See more
Orthologs

Genomic context

See ARRB1 in Genome Data Viewer
Location:
11q13.4
Exon count:
20
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (75260122..75351662, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (74971166..75062875, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene zinc finger DHHC-type containing 20 pseudogene 3 Neighboring gene trophoblast glycoprotein like Neighboring gene microRNA 326 Neighboring gene small nucleolar RNA, C/D box 15A Neighboring gene small nucleolar RNA, C/D box 15B Neighboring gene ribosomal protein S3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Overexpression of HIV-1 Tat results in a nonspecific activation of the expression of beta-arrestin PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
AP-2 adaptor complex binding IEA
Inferred from Electronic Annotation
more info
 
G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
V2 vasopressin receptor binding IEA
Inferred from Electronic Annotation
more info
 
alpha-1A adrenergic receptor binding IEA
Inferred from Electronic Annotation
more info
 
alpha-1B adrenergic receptor binding IEA
Inferred from Electronic Annotation
more info
 
angiotensin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
arrestin family protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
clathrin adaptor activity IEA
Inferred from Electronic Annotation
more info
 
cysteine-type endopeptidase inhibitor activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
enzyme inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
estrogen receptor binding IEA
Inferred from Electronic Annotation
more info
 
follicle-stimulating hormone receptor binding IEA
Inferred from Electronic Annotation
more info
 
NOT histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
insulin-like growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
ion channel binding IEA
Inferred from Electronic Annotation
more info
 
mitogen-activated protein kinase kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphorylated amino acid binding IEA
Inferred from Electronic Annotation
more info
 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription regulatory region DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor internalization IMP
Inferred from Mutant Phenotype
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
activation of MAPK activity IEA
Inferred from Electronic Annotation
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
follicle-stimulating hormone signaling pathway IEA
Inferred from Electronic Annotation
more info
 
histone acetylation IEA
Inferred from Electronic Annotation
more info
 
membrane organization TAS
Traceable Author Statement
more info
 
negative regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
negative regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of interleukin-8 production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
phototransduction IEA
Inferred from Electronic Annotation
more info
 
platelet activation TAS
Traceable Author Statement
more info
 
positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of histone H4 acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of histone acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein binding IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
positive regulation of receptor internalization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of smooth muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to drug IEA
Inferred from Electronic Annotation
more info
 
stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
chromatin IDA
Inferred from Direct Assay
more info
PubMed 
clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle membrane TAS
Traceable Author Statement
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
dendritic spine IEA
Inferred from Electronic Annotation
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
lysosomal membrane TAS
Traceable Author Statement
more info
 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
pseudopodium IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
beta-arrestin-1
Names
arrestin 2
non-visual arrestin-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028118.1 RefSeqGene

    Range
    5171..96710
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004041.5NP_004032.2  beta-arrestin-1 isoform A

    See identical proteins and their annotated locations for NP_004032.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript variant and encodes the longer isoform (A).
    Source sequence(s)
    AK293758, AL157484, AP001972, BC003636, BM681392, DA358665
    Consensus CDS
    CCDS44684.1
    UniProtKB/Swiss-Prot
    P49407
    UniProtKB/TrEMBL
    B7Z1Q3
    Related
    ENSP00000409581.2, ENST00000420843.7
    Conserved Domains (2) summary
    smart01017
    Location:193356
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:18174
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  2. NM_020251.4NP_064647.1  beta-arrestin-1 isoform B

    See identical proteins and their annotated locations for NP_064647.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1, resulting in a shorter protein (isoform B) compared to isoform A.
    Source sequence(s)
    AF084940, AK293758, AL157484, AP001972, BC003636, BM681392, DA358665
    Consensus CDS
    CCDS31640.1
    UniProtKB/Swiss-Prot
    P49407
    UniProtKB/TrEMBL
    B7Z1Q3
    Related
    ENSP00000353124.3, ENST00000360025.7
    Conserved Domains (2) summary
    smart01017
    Location:193348
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:18174
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    75260122..75351662 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017754.2XP_016873243.1  beta-arrestin-1 isoform X7

  2. XM_017017752.2XP_016873241.1  beta-arrestin-1 isoform X4

  3. XM_011545035.2XP_011543337.1  beta-arrestin-1 isoform X5

    Conserved Domains (2) summary
    smart01017
    Location:224379
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:49205
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  4. XM_017017751.1XP_016873240.1  beta-arrestin-1 isoform X2

  5. XM_011545034.2XP_011543336.1  beta-arrestin-1 isoform X3

    Conserved Domains (2) summary
    smart01017
    Location:224387
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:49205
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  6. XM_017017750.1XP_016873239.1  beta-arrestin-1 isoform X1

  7. XM_017017753.1XP_016873242.1  beta-arrestin-1 isoform X6

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