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ARRB1 arrestin beta 1 [ Homo sapiens (human) ]

Gene ID: 408, updated on 4-Feb-2024

Summary

Official Symbol
ARRB1provided by HGNC
Official Full Name
arrestin beta 1provided by HGNC
Primary source
HGNC:HGNC:711
See related
Ensembl:ENSG00000137486 MIM:107940; AllianceGenome:HGNC:711
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARB1; ARR1
Summary
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011]
Expression
Broad expression in brain (RPKM 24.0), lung (RPKM 19.9) and 24 other tissues See more
Orthologs
NEW
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Genomic context

See ARRB1 in Genome Data Viewer
Location:
11q13.4
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (75260122..75351661, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (75189729..75281255, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (74971166..75062705, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902717 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3759 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3760 Neighboring gene trophoblast glycoprotein like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:74972903-74973402 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:74973761-74974692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:74976727-74977228 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:74977229-74977728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:74983603-74984104 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:74988922-74989422 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:74991005-74991880 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:75002568-75003068 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75014529-75015343 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:75019873-75020374 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75024683-75025599 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75033894-75034520 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75035773-75036398 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75037071-75037602 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75037603-75038135 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5264 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75041995-75042528 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75042529-75043062 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75043063-75043596 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75044132-75044665 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75045734-75046268 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75046269-75046802 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75051565-75052428 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75052429-75053292 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3762 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:75057563-75058076 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:75058077-75058590 Neighboring gene microRNA 326 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5266 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3763 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75062958-75063913 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75092225-75092873 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5267 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75111125-75111988 Neighboring gene small nucleolar RNA, C/D box 15A Neighboring gene small nucleolar RNA, C/D box 15B Neighboring gene ribosomal protein S3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Overexpression of HIV-1 Tat results in a nonspecific activation of the expression of beta-arrestin PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables angiotensin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables arrestin family protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables enzyme inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
NOT enables histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables insulin-like growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in G protein-coupled receptor internalization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of interleukin-8 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of receptor internalization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in visual perception IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
part_of chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle membrane TAS
Traceable Author Statement
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in lysosomal membrane TAS
Traceable Author Statement
more info
 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in pseudopodium IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
beta-arrestin-1
Names
arrestin 2
non-visual arrestin-2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028118.1 RefSeqGene

    Range
    5171..96710
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004041.5NP_004032.2  beta-arrestin-1 isoform A

    See identical proteins and their annotated locations for NP_004032.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript variant and encodes the longer isoform (A).
    Source sequence(s)
    AK293758, AL157484, AP001972, BC003636, BM681392, DA358665
    Consensus CDS
    CCDS44684.1
    UniProtKB/Swiss-Prot
    B6V9G8, O75625, O75630, P49407, Q2PP20, Q9BTK8
    UniProtKB/TrEMBL
    A8K103
    Related
    ENSP00000409581.2, ENST00000420843.7
    Conserved Domains (2) summary
    smart01017
    Location:193356
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:18174
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  2. NM_020251.4NP_064647.1  beta-arrestin-1 isoform B

    See identical proteins and their annotated locations for NP_064647.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1, resulting in a shorter protein (isoform B) compared to isoform A.
    Source sequence(s)
    AF084940, AK293758, AL157484, AP001972, BC003636, BM681392, DA358665
    Consensus CDS
    CCDS31640.1
    UniProtKB/TrEMBL
    A8K103
    Related
    ENSP00000353124.3, ENST00000360025.7
    Conserved Domains (2) summary
    smart01017
    Location:193348
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:18174
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    75260122..75351661 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017754.3XP_016873243.1  beta-arrestin-1 isoform X7

    UniProtKB/TrEMBL
    A8K103
  2. XM_017017752.3XP_016873241.1  beta-arrestin-1 isoform X4

    UniProtKB/TrEMBL
    A8K103
  3. XM_011545035.2XP_011543337.1  beta-arrestin-1 isoform X5

    UniProtKB/TrEMBL
    A8K103
    Conserved Domains (2) summary
    smart01017
    Location:224379
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:49205
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  4. XM_017017751.1XP_016873240.1  beta-arrestin-1 isoform X2

    UniProtKB/TrEMBL
    A8K103
  5. XM_011545034.2XP_011543336.1  beta-arrestin-1 isoform X3

    UniProtKB/TrEMBL
    A8K103
    Conserved Domains (2) summary
    smart01017
    Location:224387
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:49205
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  6. XM_017017750.1XP_016873239.1  beta-arrestin-1 isoform X1

    UniProtKB/TrEMBL
    A8K103
  7. XM_017017753.1XP_016873242.1  beta-arrestin-1 isoform X6

    UniProtKB/TrEMBL
    A8K103

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    75189729..75281255 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368814.1XP_054224789.1  beta-arrestin-1 isoform X7

    UniProtKB/TrEMBL
    A8K103
  2. XM_054368811.1XP_054224786.1  beta-arrestin-1 isoform X4

    UniProtKB/TrEMBL
    A8K103
  3. XM_054368812.1XP_054224787.1  beta-arrestin-1 isoform X5

    UniProtKB/TrEMBL
    A8K103
  4. XM_054368809.1XP_054224784.1  beta-arrestin-1 isoform X2

    UniProtKB/TrEMBL
    A8K103
  5. XM_054368810.1XP_054224785.1  beta-arrestin-1 isoform X3

    UniProtKB/TrEMBL
    A8K103
  6. XM_054368808.1XP_054224783.1  beta-arrestin-1 isoform X1

    UniProtKB/TrEMBL
    A8K103
  7. XM_054368813.1XP_054224788.1  beta-arrestin-1 isoform X6

    UniProtKB/TrEMBL
    A8K103