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Sri sorcin [ Mus musculus (house mouse) ]

Gene ID: 109552, updated on 5-Mar-2024

Summary

Official Symbol
Sriprovided by MGI
Official Full Name
sorcinprovided by MGI
Primary source
MGI:MGI:98419
See related
Ensembl:ENSMUSG00000003161 AllianceGenome:MGI:98419
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sor; 2210417O06Rik; 2900070H08Rik
Summary
Enables DNA-binding transcription factor binding activity. Involved in several processes, including cytoplasmic sequestering of transcription factor; negative regulation of cardiac muscle contraction; and positive regulation of transport. Acts upstream of or within calcium ion transport. Located in Z disc; plasma membrane; and vesicle. Orthologous to human SRI (sorcin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 54.9), large intestine adult (RPKM 37.3) and 27 other tissues See more
Orthologs
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Genomic context

See Sri in Genome Data Viewer
Location:
5 A1; 5 3.38 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (8096078..8119314)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (8046078..8069314)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12377 Neighboring gene STEAP family member 4 Neighboring gene STARR-seq mESC enhancer starr_12379 Neighboring gene predicted gene, 52802 Neighboring gene predicted gene 15731 Neighboring gene 60S ribosomal protein L27 pseudogene Neighboring gene a disintegrin and metallopeptidase domain 22 Neighboring gene STARR-seq mESC enhancer starr_12380 Neighboring gene STARR-seq mESC enhancer starr_12381 Neighboring gene predicted gene, 21759 Neighboring gene predicted gene, 23993

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within calcium ion transport IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in cytoplasmic sequestering of transcription factor IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cardiac muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of heart rate ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of ryanodine-sensitive calcium-release channel activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription regulatory region DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of release of sequestered calcium ion into cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cardiac muscle cell contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell communication by electrical coupling involved in cardiac conduction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of high voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of relaxation of muscle ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in T-tubule ISO
Inferred from Sequence Orthology
more info
 
located_in Z disc IDA
Inferred from Direct Assay
more info
PubMed 
located_in Z disc ISO
Inferred from Sequence Orthology
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with chromaffin granule membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine neck ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in sarcoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in vesicle IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080974.2NP_001074443.1  sorcin isoform 1

    See identical proteins and their annotated locations for NP_001074443.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK134747, AK168572, BQ033487
    Consensus CDS
    CCDS39009.1
    UniProtKB/Swiss-Prot
    Q3UKC5, Q6P069, Q9CR38, Q9D7V8
    Related
    ENSMUSP00000118221.2, ENSMUST00000148633.4
    Conserved Domains (1) summary
    cd16187
    Location:34198
    EFh_PEF_sorcin; Penta-EF hand, calcium binding motifs, found in sorcin
  2. NM_025618.3NP_079894.2  sorcin isoform 2

    See identical proteins and their annotated locations for NP_079894.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region, compared to variant 1. It encodes isoform 2, which has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK008404, AK008783, AK168572, BQ033487
    Consensus CDS
    CCDS19079.1
    UniProtKB/Swiss-Prot
    Q6P069
    Related
    ENSMUSP00000086165.5, ENSMUST00000088786.11
    Conserved Domains (2) summary
    cd00051
    Location:60115
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl08302
    Location:97146
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    8096078..8119314
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503527.1XP_006503590.1  sorcin isoform X1

    Conserved Domains (2) summary
    cd15897
    Location:1949
    EFh_PEF; EF-hand motif [structural motif]
    cl25352
    Location:1113
    EFh_PEF; The penta-EF hand (PEF) family
  2. XM_017320600.3XP_017176089.1  sorcin isoform X1

    Conserved Domains (2) summary
    cd15897
    Location:1949
    EFh_PEF; EF-hand motif [structural motif]
    cl25352
    Location:1113
    EFh_PEF; The penta-EF hand (PEF) family