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SRI sorcin [ Homo sapiens (human) ]

Gene ID: 6717, updated on 8-Dec-2018

Summary

Official Symbol
SRIprovided by HGNC
Official Full Name
sorcinprovided by HGNC
Primary source
HGNC:HGNC:11292
See related
Ensembl:ENSG00000075142 MIM:182520
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SCN; V19; CP22; CP-22
Summary
This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene. [provided by RefSeq, Mar 2012]
Expression
Broad expression in colon (RPKM 86.4), brain (RPKM 64.5) and 24 other tissues See more
Orthologs

Genomic context

See SRI in Genome Data Viewer
Location:
7q21.12
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (88205115..88226993, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (87834430..87856308, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 40 Neighboring gene origin of replication in promoter of DBF4 Neighboring gene DBF4 zinc finger Neighboring gene ADAM metallopeptidase domain 22 Neighboring gene uncharacterized LOC105375386 Neighboring gene uncharacterized LOC102723885 Neighboring gene STEAP4 metalloreductase Neighboring gene uncharacterized LOC107986815

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
capsid gag The interaction of HIV-1 CA with human cellular sorcin (SRI) is identified by yeast two-hybrid screen PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Cardiac conduction, organism-specific biosystem (from REACTOME)
    Cardiac conduction, organism-specific biosystemThe normal sequence of contraction of atria and ventricles of the heart require activation of groups of cardiac cells. The mechanism must elicit rapid changes in heart rate and respond to changes in ...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Ion channel transport, organism-specific biosystem (from REACTOME)
    Ion channel transport, organism-specific biosystemIon channels mediate the flow of ions across the plasma membrane of cells. They are integral membrane proteins, typically a multimer of proteins, which, when arranged in the membrane, create a pore f...
  • Ion homeostasis, organism-specific biosystem (from REACTOME)
    Ion homeostasis, organism-specific biosystemIon channel homeostasis in relation to cardiac conduction is described in this section (Couette et al. 2006, Bartos et al. 2015).
  • Ion transport by P-type ATPases, organism-specific biosystem (from REACTOME)
    Ion transport by P-type ATPases, organism-specific biosystemThe P-type ATPases (E1-E2 ATPases) are a large group of evolutionarily related ion pumps that are found in bacteria, archaea and eukaryotes. They are referred to as P-type ATPases because they catal...
  • Muscle contraction, organism-specific biosystem (from REACTOME)
    Muscle contraction, organism-specific biosystemIn this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated.
  • Platelet calcium homeostasis, organism-specific biosystem (from REACTOME)
    Platelet calcium homeostasis, organism-specific biosystemCa2+ homeostasis is controlled by processes that elevate or counter the elevation of cytosolic Ca2+. During steady state conditions, cytoplasmic Ca2+ is reduced by the accumulation of Ca2+ in intrac...
  • Platelet homeostasis, organism-specific biosystem (from REACTOME)
    Platelet homeostasis, organism-specific biosystemUnder normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhesion and activation, suppresses coagulation, enhances fibrin cleavage and is anti-inflammatory in charact...
  • Reduction of cytosolic Ca++ levels, organism-specific biosystem (from REACTOME)
    Reduction of cytosolic Ca++ levels, organism-specific biosystemDuring steady state conditions, cytoplasmic [Ca2+] is reduced by the accumulation of Ca2+ in intracellular stores and Ca2+ extrusion.
  • SLC-mediated transmembrane transport, organism-specific biosystem (from REACTOME)
    SLC-mediated transmembrane transport, organism-specific biosystemProteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the m...
  • Sodium/Calcium exchangers, organism-specific biosystem (from REACTOME)
    Sodium/Calcium exchangers, organism-specific biosystemCalcium ions are used by cells as ubiquitous signalling molecules that control diverse physiological events. Three mammalian gene families control Ca2+ transport across plasma membranes and intracell...
  • Stimuli-sensing channels, organism-specific biosystem (from REACTOME)
    Stimuli-sensing channels, organism-specific biosystemIon channels that mediate sensations such as pain, warmth, cold, taste pressure and vision. Channels that mediate these sensations include acid-sensing ion channels (ASICs) (Wang & Xu 2011, Qadri et ...
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystem
    Transmembrane transport of small molecules
  • Transport of inorganic cations/anions and amino acids/oligopeptides, organism-specific biosystem (from REACTOME)
    Transport of inorganic cations/anions and amino acids/oligopeptides, organism-specific biosystemTeleologically, one might argue that inorganic cation and anion transport would be evolutionarily among the oldest transport functions. Eight families comprise the group that transports exclusively i...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ26259

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium channel regulator activity TAS
Traceable Author Statement
more info
PubMed 
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
ion channel binding TAS
Traceable Author Statement
more info
PubMed 
protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
repressing transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
action potential TAS
Traceable Author Statement
more info
PubMed 
calcium ion transport IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic sequestering of transcription factor IEA
Inferred from Electronic Annotation
more info
 
heart development IEA
Inferred from Electronic Annotation
more info
 
intracellular sequestering of iron ion TAS
Traceable Author Statement
more info
PubMed 
muscle organ development TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cardiac muscle contraction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of heart rate IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of ryanodine-sensitive calcium-release channel activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription regulatory region DNA binding IEA
Inferred from Electronic Annotation
more info
 
positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
positive regulation of release of sequestered calcium ion into cytosol IEA
Inferred from Electronic Annotation
more info
 
regulation of calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cardiac muscle cell contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell communication by electrical coupling TAS
Traceable Author Statement
more info
PubMed 
regulation of cell communication by electrical coupling involved in cardiac conduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of heart contraction TAS
Traceable Author Statement
more info
PubMed 
regulation of high voltage-gated calcium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of relaxation of muscle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
regulation of striated muscle contraction TAS
Traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
T-tubule TAS
Traceable Author Statement
more info
PubMed 
Z disc IDA
Inferred from Direct Assay
more info
PubMed 
axon terminus IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with chromaffin granule membrane IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
dendritic spine neck IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
sarcoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
sarcoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
smooth endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sorcin
Names
22 kDa protein
H_RG167B05.1
calcium binding protein amplified in mutlidrug-resistant cells

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032138.1 RefSeqGene

    Range
    5001..26877
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_414

mRNA and Protein(s)

  1. NM_001256891.1NP_001243820.1  sorcin isoform C

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR, compared to variant 1. These differences result in a protein (isoform C) with a shorter and distinct C-terminus, compared to isoform A.
    Source sequence(s)
    AK296601, BI524104, DA268050
    UniProtKB/Swiss-Prot
    P30626
    Conserved Domains (1) summary
    cd00051
    Location:75130
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  2. NM_001256892.1NP_001243821.1  sorcin isoform D

    See identical proteins and their annotated locations for NP_001243821.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has multiple differences compared to variant 1. These differences result in a protein (isoform D) with shorter and distinct N- and C-termini, compared to isoform A.
    Source sequence(s)
    AK296601, BM739144
    Consensus CDS
    CCDS59063.1
    UniProtKB/Swiss-Prot
    P30626
    Related
    ENSP00000391148.1, ENST00000431660.5
    Conserved Domains (1) summary
    cd16187
    Location:19175
    EFh_PEF_sorcin; Penta-EF hand, calcium binding motifs, found in sorcin
  3. NM_003130.3NP_003121.1  sorcin isoform A

    See identical proteins and their annotated locations for NP_003121.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (A).
    Source sequence(s)
    AK129770, AK295225, AL117616, DA268050, DB540255
    Consensus CDS
    CCDS5612.1
    UniProtKB/Swiss-Prot
    P30626
    UniProtKB/TrEMBL
    B4DHQ6
    Related
    ENSP00000265729.2, ENST00000265729.6
    Conserved Domains (1) summary
    cd16187
    Location:34198
    EFh_PEF_sorcin; Penta-EF hand, calcium binding motifs, found in sorcin
  4. NM_198901.1NP_944490.1  sorcin isoform B

    See identical proteins and their annotated locations for NP_944490.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region and uses an alternate translational start codon, compared to variant 1. These differences result in a protein (isoform B) with a shorter and distinct N-terminus, compared to isoform A.
    Source sequence(s)
    AL117616, AL576812, BM739144, BM793972
    Consensus CDS
    CCDS47638.1
    UniProtKB/Swiss-Prot
    P30626
    Related
    ENSP00000378137.3, ENST00000394641.7
    Conserved Domains (1) summary
    cd16187
    Location:19183
    EFh_PEF_sorcin; Penta-EF hand, calcium binding motifs, found in sorcin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    88205115..88226993 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516528.1XP_011514830.1  sorcin isoform X1

    UniProtKB/TrEMBL
    C9J0K6
    Related
    ENSP00000418512.1, ENST00000490437.5
    Conserved Domains (2) summary
    cd15897
    Location:3160
    EFh_PEF; EF-hand motif [structural motif]
    cl25352
    Location:2155
    EFh_PEF; The penta-EF hand (PEF) family
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