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TCERG1 transcription elongation regulator 1 [ Homo sapiens (human) ]

Gene ID: 10915, updated on 13-May-2022

Summary

Official Symbol
TCERG1provided by HGNC
Official Full Name
transcription elongation regulator 1provided by HGNC
Primary source
HGNC:HGNC:15630
See related
Ensembl:ENSG00000113649 MIM:605409; AllianceGenome:HGNC:15630
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Urn1; CA150; TAF2S
Summary
This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 13.4), bone marrow (RPKM 13.0) and 25 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See TCERG1 in Genome Data Viewer
Location:
5q32
Exon count:
34
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (146447330..146511961)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (146983202..147047833)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (145826893..145891524)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378213 Neighboring gene Sharpr-MPRA regulatory region 15640 Neighboring gene G protein-coupled receptor 151 Neighboring gene uncharacterized CTB-99A3.1 Neighboring gene RNA, 5S ribosomal pseudogene 196 Neighboring gene protein phosphatase 2 regulatory subunit Bbeta

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Both CA150 and HIV-1 Tat associate with the RNA polymerase II holoenzyme and are required for Tat transactivation of the HIV-1 LTR promoter PubMed
tat HIV-1 Tat-mediated splicing is dependent on splicing associated factors Tat-SF1 and CA150 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC133200

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in nuclear speck TAS
Traceable Author Statement
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transcription elongation regulator 1
Names
TATA box binding protein (TBP)-associated factor, RNA polymerase II, S, 150kD
TATA box-binding protein-associated factor 2S
co-activator of 150 kDa
transcription factor CA150

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040006.2NP_001035095.1  transcription elongation regulator 1 isoform 2

    See identical proteins and their annotated locations for NP_001035095.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame coding exons compared to variant 3, resulting in a shorter protein (isoform 2) compared to isoform 3.
    Source sequence(s)
    AB209910, AC011375, AF017789, DA034307, DA737038
    Consensus CDS
    CCDS43379.1
    UniProtKB/Swiss-Prot
    O14776
    Related
    ENSP00000377943.2, ENST00000394421.7
    Conserved Domains (4) summary
    COG5104
    Location:400997
    PRP40; Splicing factor [RNA processing and modification]
    pfam00397
    Location:137162
    WW; WW domain
    pfam01846
    Location:9941053
    FF; FF domain
    pfam03154
    Location:258395
    Atrophin-1; Atrophin-1 family
  2. NM_001382548.1NP_001369477.1  transcription elongation regulator 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3).
    Source sequence(s)
    AC011375
    Related
    ENSP00000505217.1, ENST00000679501.2
    Conserved Domains (5) summary
    smart00456
    Location:132164
    WW; Domain with 2 conserved Trp (W) residues
    COG5104
    Location:4211035
    PRP40; Splicing factor [RNA processing and modification]
    pfam05109
    Location:260365
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01846
    Location:10321091
    FF; FF domain
    cl28929
    Location:323413
    VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)
  3. NM_001400077.1NP_001387006.1  transcription elongation regulator 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC011375
  4. NM_001400082.1NP_001387011.1  transcription elongation regulator 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC011375
  5. NM_001400083.1NP_001387012.1  transcription elongation regulator 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC011375
  6. NM_001400084.1NP_001387013.1  transcription elongation regulator 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC011375
  7. NM_001400085.1NP_001387014.1  transcription elongation regulator 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC011375
  8. NM_001400092.1NP_001387021.1  transcription elongation regulator 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC011375
  9. NM_001400093.1NP_001387022.1  transcription elongation regulator 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC011375
  10. NM_001400094.1NP_001387023.1  transcription elongation regulator 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC011375
  11. NM_001400095.1NP_001387024.1  transcription elongation regulator 1 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC011375
  12. NM_001400096.1NP_001387025.1  transcription elongation regulator 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC011375
  13. NM_001400097.1NP_001387026.1  transcription elongation regulator 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC011375
  14. NM_001400098.1NP_001387027.1  transcription elongation regulator 1 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC011375
  15. NM_001400099.1NP_001387028.1  transcription elongation regulator 1 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC011375
  16. NM_006706.4NP_006697.2  transcription elongation regulator 1 isoform 1

    See identical proteins and their annotated locations for NP_006697.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame coding exon compared to variant 3, resulting in a shorter protein (isoform 1) compared to isoform 3.
    Source sequence(s)
    AC011375, AF017789, BC111727, DA034307, DA737038
    Consensus CDS
    CCDS4282.1
    UniProtKB/Swiss-Prot
    O14776
    Related
    ENSP00000296702.5, ENST00000296702.9
    Conserved Domains (5) summary
    COG5104
    Location:4211018
    PRP40; Splicing factor [RNA processing and modification]
    pfam05109
    Location:260365
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00397
    Location:137162
    WW; WW domain
    pfam01846
    Location:10151074
    FF; FF domain
    cl28929
    Location:323413
    VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

RNA

  1. NR_174389.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  2. NR_174390.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  3. NR_174391.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  4. NR_174406.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  5. NR_174407.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  6. NR_174408.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  7. NR_174409.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  8. NR_174410.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  9. NR_174411.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  10. NR_174412.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  11. NR_174413.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  12. NR_174414.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  13. NR_174415.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  14. NR_174416.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  15. NR_174417.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  16. NR_174418.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  17. NR_174419.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  18. NR_174420.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  19. NR_174421.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  20. NR_174422.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  21. NR_174423.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  22. NR_174424.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  23. NR_174425.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  24. NR_174426.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  25. NR_174427.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  26. NR_174428.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  27. NR_174429.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  28. NR_174430.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  29. NR_174431.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  30. NR_174432.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  31. NR_174433.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  32. NR_174434.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  33. NR_174435.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  34. NR_174436.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  35. NR_174437.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  36. NR_174438.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  37. NR_174439.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  38. NR_174440.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  39. NR_174441.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  40. NR_174442.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  41. NR_174443.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  42. NR_174444.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  43. NR_174445.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  44. NR_174446.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  45. NR_174447.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  46. NR_174448.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  47. NR_174449.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  48. NR_174450.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  49. NR_174451.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  50. NR_174452.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  51. NR_174453.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375
  52. NR_174454.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011375

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    146447330..146511961
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008978.3XP_016864467.1  transcription elongation regulator 1 isoform X1

  2. XM_017008979.3XP_016864468.1  transcription elongation regulator 1 isoform X2

  3. XM_047416659.1XP_047272615.1  transcription elongation regulator 1 isoform X3

  4. XM_017008980.2XP_016864469.1  transcription elongation regulator 1 isoform X4

  5. XM_047416660.1XP_047272616.1  transcription elongation regulator 1 isoform X7

  6. XM_017008984.2XP_016864473.1  transcription elongation regulator 1 isoform X5

  7. XM_017008985.2XP_016864474.1  transcription elongation regulator 1 isoform X6

RNA

  1. XR_001741983.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    146983202..147047833
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)