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TCERG1 transcription elongation regulator 1 [ Homo sapiens (human) ]

Gene ID: 10915, updated on 11-Jun-2021

Summary

Official Symbol
TCERG1provided by HGNC
Official Full Name
transcription elongation regulator 1provided by HGNC
Primary source
HGNC:HGNC:15630
See related
Ensembl:ENSG00000113649 MIM:605409
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Urn1; CA150; TAF2S
Summary
This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 13.4), bone marrow (RPKM 13.0) and 25 other tissues See more
Orthologs
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Genomic context

See TCERG1 in Genome Data Viewer
Location:
5q32
Exon count:
26
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (146447330..146511961)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (145826896..145891524)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378213 Neighboring gene POU class 4 homeobox 3 Neighboring gene G protein-coupled receptor 151 Neighboring gene uncharacterized CTB-99A3.1 Neighboring gene RNA, 5S ribosomal pseudogene 196 Neighboring gene protein phosphatase 2 regulatory subunit Bbeta

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Both CA150 and HIV-1 Tat associate with the RNA polymerase II holoenzyme and are required for Tat transactivation of the HIV-1 LTR promoter PubMed
tat HIV-1 Tat-mediated splicing is dependent on splicing associated factors Tat-SF1 and CA150 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC133200

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in nuclear speck TAS
Traceable Author Statement
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transcription elongation regulator 1
Names
TATA box binding protein (TBP)-associated factor, RNA polymerase II, S, 150kD
TATA box-binding protein-associated factor 2S
co-activator of 150 kDa
transcription factor CA150

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040006.2NP_001035095.1  transcription elongation regulator 1 isoform 2

    See identical proteins and their annotated locations for NP_001035095.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame coding exons compared to variant 3, resulting in a shorter protein (isoform 2) compared to isoform 3.
    Source sequence(s)
    AB209910, AC011375, AF017789, DA034307, DA737038
    Consensus CDS
    CCDS43379.1
    UniProtKB/Swiss-Prot
    O14776
    Related
    ENSP00000377943.2, ENST00000394421.7
    Conserved Domains (4) summary
    smart00441
    Location:9921056
    FF; Contains two conserved F residues
    smart00456
    Location:132164
    WW; Domain with 2 conserved Trp (W) residues
    COG5104
    Location:400997
    PRP40; Splicing factor [RNA processing and modification]
    pfam03154
    Location:258395
    Atrophin-1; Atrophin-1 family
  2. NM_001382548.1NP_001369477.1  transcription elongation regulator 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3).
    Source sequence(s)
    AC011375
    Related
    ENSP00000505217.1, ENST00000679501.2
    Conserved Domains (5) summary
    smart00456
    Location:132164
    WW; Domain with 2 conserved Trp (W) residues
    COG5104
    Location:4211035
    PRP40; Splicing factor [RNA processing and modification]
    pfam05109
    Location:260365
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01846
    Location:10321091
    FF; FF domain
    cl28929
    Location:323413
    VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)
  3. NM_006706.4NP_006697.2  transcription elongation regulator 1 isoform 1

    See identical proteins and their annotated locations for NP_006697.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame coding exon compared to variant 3, resulting in a shorter protein (isoform 1) compared to isoform 3.
    Source sequence(s)
    AC011375, AF017789, BC111727, DA034307, DA737038
    Consensus CDS
    CCDS4282.1
    UniProtKB/Swiss-Prot
    O14776
    Related
    ENSP00000296702.5, ENST00000296702.9
    Conserved Domains (5) summary
    smart00441
    Location:10131077
    FF; Contains two conserved F residues
    PRK13729
    Location:323413
    PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
    smart00456
    Location:132164
    WW; Domain with 2 conserved Trp (W) residues
    COG5104
    Location:4211018
    PRP40; Splicing factor [RNA processing and modification]
    pfam05109
    Location:260365
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    146447330..146511961
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008982.2XP_016864471.1  transcription elongation regulator 1 isoform X8

  2. XM_017008983.2XP_016864472.1  transcription elongation regulator 1 isoform X9

  3. XM_017008978.2XP_016864467.1  transcription elongation regulator 1 isoform X3

  4. XM_017008979.2XP_016864468.1  transcription elongation regulator 1 isoform X4

  5. XM_017008977.2XP_016864466.1  transcription elongation regulator 1 isoform X2

    Conserved Domains (4) summary
    smart00441
    Location:10091073
    FF; Contains two conserved F residues
    smart00456
    Location:132164
    WW; Domain with 2 conserved Trp (W) residues
    COG5104
    Location:4001014
    PRP40; Splicing factor [RNA processing and modification]
    pfam03154
    Location:258395
    Atrophin-1; Atrophin-1 family
  6. XM_017008980.2XP_016864469.1  transcription elongation regulator 1 isoform X5

  7. XM_017008984.2XP_016864473.1  transcription elongation regulator 1 isoform X10

  8. XM_017008985.2XP_016864474.1  transcription elongation regulator 1 isoform X11

  9. XM_024454341.1XP_024310109.1  transcription elongation regulator 1 isoform X6

    Conserved Domains (3) summary
    smart00441
    Location:756820
    FF; Contains two conserved F residues
    cl00157
    Location:147761
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cl26464
    Location:21161
    Atrophin-1; Atrophin-1 family
  10. XM_024454342.1XP_024310110.1  transcription elongation regulator 1 isoform X7

    Conserved Domains (3) summary
    smart00441
    Location:739803
    FF; Contains two conserved F residues
    cl00157
    Location:147744
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cl26464
    Location:21161
    Atrophin-1; Atrophin-1 family

RNA

  1. XR_001741980.2 RNA Sequence

  2. XR_001741983.2 RNA Sequence

  3. XR_002959840.1 RNA Sequence

  4. XR_001741981.2 RNA Sequence

    Related
    ENST00000549332.1
  5. XR_001741982.2 RNA Sequence

  6. XR_001741984.2 RNA Sequence

  7. XR_001741985.2 RNA Sequence

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