Format

Send to:

Choose Destination

TCERG1 transcription elongation regulator 1 [ Homo sapiens (human) ]

Gene ID: 10915, updated on 9-Dec-2018

Summary

Official Symbol
TCERG1provided by HGNC
Official Full Name
transcription elongation regulator 1provided by HGNC
Primary source
HGNC:HGNC:15630
See related
Ensembl:ENSG00000113649 MIM:605409
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Urn1; CA150; TAF2S
Summary
This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 13.4), bone marrow (RPKM 13.0) and 25 other tissues See more
Orthologs

Genomic context

See TCERG1 in Genome Data Viewer
Location:
5q32
Exon count:
28
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (146447310..146511508)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (145826873..145891071)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene POU class 4 homeobox 3 Neighboring gene uncharacterized LOC105378213 Neighboring gene G protein-coupled receptor 151 Neighboring gene uncharacterized CTB-99A3.1 Neighboring gene RNA, 5S ribosomal pseudogene 196

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Both CA150 and HIV-1 Tat associate with the RNA polymerase II holoenzyme and are required for Tat transactivation of the HIV-1 LTR promoter PubMed
tat HIV-1 Tat-mediated splicing is dependent on splicing associated factors Tat-SF1 and CA150 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Spliceosome, organism-specific biosystem (from KEGG)
    Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
  • Spliceosome, conserved biosystem (from KEGG)
    Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC133200

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA polymerase II repressing transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
proline-rich region binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity TAS
Traceable Author Statement
more info
PubMed 
transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transcription elongation regulator 1
Names
TATA box binding protein (TBP)-associated factor, RNA polymerase II, S, 150kD
TATA box-binding protein-associated factor 2S
co-activator of 150 kDa
transcription factor CA150

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040006.1NP_001035095.1  transcription elongation regulator 1 isoform 2

    See identical proteins and their annotated locations for NP_001035095.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1, resulting in a shorter protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    AB209910, AF017789, DA034307, DA737038
    Consensus CDS
    CCDS43379.1
    UniProtKB/Swiss-Prot
    O14776
    Related
    ENSP00000377943.2, ENST00000394421.6
    Conserved Domains (5) summary
    smart00441
    Location:934989
    FF; Contains two conserved F residues
    cl14654
    Location:806884
    V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
    smart00456
    Location:132164
    WW; Domain with 2 conserved Trp (W) residues
    cd00201
    Location:412439
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam01846
    Location:773822
    FF; FF domain
  2. NM_006706.3NP_006697.2  transcription elongation regulator 1 isoform 1

    See identical proteins and their annotated locations for NP_006697.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF017789, BC111727, DA034307, DA737038
    Consensus CDS
    CCDS4282.1
    UniProtKB/Swiss-Prot
    O14776
    Related
    ENSP00000296702.5, ENST00000296702.9
    Conserved Domains (5) summary
    smart00441
    Location:9551010
    FF; Contains two conserved F residues
    cl14654
    Location:827905
    V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
    smart00456
    Location:132164
    WW; Domain with 2 conserved Trp (W) residues
    cd00201
    Location:433460
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam01846
    Location:794843
    FF; FF domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    146447310..146511508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008982.2XP_016864471.1  transcription elongation regulator 1 isoform X8

  2. XM_017008983.2XP_016864472.1  transcription elongation regulator 1 isoform X9

  3. XM_005268365.3XP_005268422.1  transcription elongation regulator 1 isoform X1

    Conserved Domains (5) summary
    smart00441
    Location:9721027
    FF; Contains two conserved F residues
    cl14654
    Location:844922
    V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
    smart00456
    Location:132164
    WW; Domain with 2 conserved Trp (W) residues
    cd00201
    Location:433460
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam01846
    Location:811860
    FF; FF domain
  4. XM_017008978.2XP_016864467.1  transcription elongation regulator 1 isoform X3

  5. XM_017008979.2XP_016864468.1  transcription elongation regulator 1 isoform X4

  6. XM_017008977.2XP_016864466.1  transcription elongation regulator 1 isoform X2

  7. XM_017008980.2XP_016864469.1  transcription elongation regulator 1 isoform X5

  8. XM_017008984.2XP_016864473.1  transcription elongation regulator 1 isoform X10

  9. XM_017008985.2XP_016864474.1  transcription elongation regulator 1 isoform X11

  10. XM_024454341.1XP_024310109.1  transcription elongation regulator 1 isoform X6

    Conserved Domains (3) summary
    smart00441
    Location:756820
    FF; Contains two conserved F residues
    cl00157
    Location:147761
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cl26464
    Location:21161
    Atrophin-1; Atrophin-1 family
  11. XM_024454342.1XP_024310110.1  transcription elongation regulator 1 isoform X7

    Conserved Domains (3) summary
    smart00441
    Location:739803
    FF; Contains two conserved F residues
    cl00157
    Location:147744
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cl26464
    Location:21161
    Atrophin-1; Atrophin-1 family

RNA

  1. XR_001741980.2 RNA Sequence

  2. XR_001741983.2 RNA Sequence

  3. XR_002959840.1 RNA Sequence

  4. XR_001741981.2 RNA Sequence

    Related
    ENST00000549332.1
  5. XR_001741982.2 RNA Sequence

  6. XR_001741984.2 RNA Sequence

  7. XR_001741985.2 RNA Sequence

Support Center