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Tcerg1 transcription elongation regulator 1 (CA150) [ Mus musculus (house mouse) ]

Gene ID: 56070, updated on 2-Jul-2024

Summary

Official Symbol
Tcerg1provided by MGI
Official Full Name
transcription elongation regulator 1 (CA150)provided by MGI
Primary source
MGI:MGI:1926421
See related
Ensembl:ENSMUSG00000024498 AllianceGenome:MGI:1926421
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p144; FBP23; FBP28; Taf2s; ca150; CA150b; 2410022J09Rik; 2900090C16Rik
Summary
Enables proline-rich region binding activity. Predicted to be involved in RNA processing and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within transcription, DNA-templated. Predicted to be located in nuclear matrix and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; limb bud; liver; metanephros; and pancreas epithelium. Orthologous to human TCERG1 (transcription elongation regulator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 20.3), CNS E14 (RPKM 15.7) and 28 other tissues See more
Orthologs
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Genomic context

See Tcerg1 in Genome Data Viewer
Location:
18 B3; 18 22.66 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (42644369..42708850)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (42511304..42575785)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31501 Neighboring gene STARR-seq mESC enhancer starr_44441 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:42670844-42671027 Neighboring gene STARR-seq mESC enhancer starr_44443 Neighboring gene STARR-positive B cell enhancer mm9_chr18:42717560-42717861 Neighboring gene STARR-positive B cell enhancer ABC_E400 Neighboring gene G protein-coupled receptor 151 Neighboring gene RIKEN cDNA C030004G16 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables proline-rich region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-like protein conjugating enzyme binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in RNA splicing ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA processing ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in nuclear matrix ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
transcription elongation regulator 1
Names
TATA box binding protein (TBP)-associated factor, RNA polymerase II, S, 150kD
TATA box-binding protein-associated factor 2S
coactivator of 150 kD
formin-binding protein 28
transcription factor CA150
transcription factor CA150b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039474.1NP_001034563.1  transcription elongation regulator 1 isoform 1

    See identical proteins and their annotated locations for NP_001034563.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK082750, AK168434, CJ052824
    Consensus CDS
    CCDS29214.1
    UniProtKB/Swiss-Prot
    Q61051, Q8C490, Q8CGF7, Q8CHT8, Q9R0R5
    UniProtKB/TrEMBL
    Q3TH57
    Related
    ENSMUSP00000158288.2, ENSMUST00000237602.2
    Conserved Domains (4) summary
    smart00441
    Location:9571012
    FF; Contains two conserved F residues
    smart00456
    Location:132164
    WW; Domain with 2 conserved Trp (W) residues
    cd00201
    Location:435464
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam01846
    Location:796845
    FF; FF domain
  2. NM_001289526.1NP_001276455.1  transcription elongation regulator 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and contains an alternate 3' exon, compared to variant 1. This results in a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AC121603, AK076993, AK082750, AK150312, CJ052824
    UniProtKB/Swiss-Prot
    Q8CGF7
    Conserved Domains (4) summary
    smart00441
    Location:9531008
    FF; Contains two conserved F residues
    smart00456
    Location:132164
    WW; Domain with 2 conserved Trp (W) residues
    cd00201
    Location:414443
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam01846
    Location:792841
    FF; FF domain
  3. NM_001360881.1NP_001347810.1  transcription elongation regulator 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter isoform (3), compared to isoform 1.
    Source sequence(s)
    AC121603
    Consensus CDS
    CCDS89230.1
    Related
    ENSMUSP00000025375.9, ENSMUST00000025375.15
    Conserved Domains (4) summary
    smart00441
    Location:9941058
    FF; Contains two conserved F residues
    smart00456
    Location:132164
    WW; Domain with 2 conserved Trp (W) residues
    cl00157
    Location:402999
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cl25496
    Location:258346
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

RNA

  1. NR_110344.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 3' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC121603, AK082750, AK168434, CJ052824

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    42644369..42708850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526111.4XP_006526174.1  transcription elongation regulator 1 isoform X2

    Conserved Domains (4) summary
    smart00441
    Location:10321096
    FF; Contains two conserved F residues
    smart00456
    Location:132164
    WW; Domain with 2 conserved Trp (W) residues
    COG5104
    Location:4231037
    PRP40; Splicing factor [RNA processing and modification]
    pfam03154
    Location:258418
    Atrophin-1; Atrophin-1 family
  2. XM_006526110.4XP_006526173.1  transcription elongation regulator 1 isoform X1

    Conserved Domains (4) summary
    smart00441
    Location:10381102
    FF; Contains two conserved F residues
    smart00456
    Location:132164
    WW; Domain with 2 conserved Trp (W) residues
    COG5104
    Location:4291043
    PRP40; Splicing factor [RNA processing and modification]
    pfam05109
    Location:258352
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  3. XM_006526112.5XP_006526175.1  transcription elongation regulator 1 isoform X3

    Conserved Domains (4) summary
    smart00441
    Location:10211085
    FF; Contains two conserved F residues
    smart00456
    Location:132164
    WW; Domain with 2 conserved Trp (W) residues
    COG5104
    Location:4291026
    PRP40; Splicing factor [RNA processing and modification]
    pfam05109
    Location:258352
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  4. XM_006526113.4XP_006526176.1  transcription elongation regulator 1 isoform X4

    Conserved Domains (4) summary
    smart00441
    Location:10171081
    FF; Contains two conserved F residues
    smart00456
    Location:132164
    WW; Domain with 2 conserved Trp (W) residues
    COG5104
    Location:4081022
    PRP40; Splicing factor [RNA processing and modification]
    pfam03154
    Location:258403
    Atrophin-1; Atrophin-1 family
  5. XM_030250545.2XP_030106405.1  transcription elongation regulator 1 isoform X5

    Conserved Domains (4) summary
    smart00441
    Location:10001064
    FF; Contains two conserved F residues
    smart00456
    Location:132164
    WW; Domain with 2 conserved Trp (W) residues
    COG5104
    Location:4081005
    PRP40; Splicing factor [RNA processing and modification]
    pfam03154
    Location:258403
    Atrophin-1; Atrophin-1 family

RNA

  1. XR_004939874.1 RNA Sequence

  2. XR_001782385.3 RNA Sequence

  3. XR_001782384.3 RNA Sequence

  4. XR_004939873.1 RNA Sequence

  5. XR_386004.5 RNA Sequence

  6. XR_001782386.3 RNA Sequence

  7. XR_001782383.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_019512.1: Suppressed sequence

    Description
    NM_019512.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.