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PAPOLA poly(A) polymerase alpha [ Homo sapiens (human) ]

Gene ID: 10914, updated on 26-Jul-2021

Summary

Official Symbol
PAPOLAprovided by HGNC
Official Full Name
poly(A) polymerase alphaprovided by HGNC
Primary source
HGNC:HGNC:14981
See related
Ensembl:ENSG00000090060 MIM:605553
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAP; PAP-alpha
Summary
The protein encoded by this gene belongs to the poly(A) polymerase family. It is required for the addition of adenosine residues for the creation of the 3'-poly(A) tail of mRNAs. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in testis (RPKM 27.7), thyroid (RPKM 22.4) and 25 other tissues See more
Orthologs
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Genomic context

See PAPOLA in Genome Data Viewer
Location:
14q32.2
Exon count:
23
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (96502376..96567116)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (96968713..97033453)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene adenylate kinase 7 Neighboring gene ribosomal protein L23a pseudogene 10 Neighboring gene PAPOLA divergent transcript Neighboring gene RN7SK pseudogene 108 Neighboring gene uncharacterized LOC105370645

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat The poly(A) site in the HIV-1 5'-LTR is occluded in a Tat-dependent manner, suggesting a role for Tat in regulating this nucleotide signal PubMed
Vpr vpr HIV-1 Vpr dephosphorylates poly(A) polymerase (PAP), presumably through inhibition of the p34cdc2/cyclin B kinase complex, leading to enhanced PAP activity PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC5378, FLJ33067

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables manganese ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables polynucleotide adenylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables polynucleotide adenylyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables polynucleotide adenylyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables polynucleotide adenylyltransferase activity TAS
Traceable Author Statement
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA polyadenylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mRNA 3'-end processing TAS
Traceable Author Statement
more info
 
involved_in mRNA polyadenylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mRNA polyadenylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of mRNA 3'-end processing IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
poly(A) polymerase alpha
Names
polynucleotide adenylyltransferase alpha
NP_001238935.1
NP_001238936.1
NP_001280556.1
NP_001280557.1
NP_001280561.1
NP_001350591.1
NP_001350593.1
NP_001350594.1
NP_001350595.1
NP_116021.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030439.1 RefSeqGene

    Range
    5001..69741
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001252006.1NP_001238935.1  poly(A) polymerase alpha isoform 2

    See identical proteins and their annotated locations for NP_001238935.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks multiple exons and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL163051, BX089817, BX248753, DB045100
    Consensus CDS
    CCDS58334.1
    UniProtKB/Swiss-Prot
    P51003
    Related
    ENSP00000450437.1, ENST00000557320.5
    Conserved Domains (1) summary
    pfam04928
    Location:21279
    PAP_central; Poly(A) polymerase central domain
  2. NM_001252007.1NP_001238936.1  poly(A) polymerase alpha isoform 3

    See identical proteins and their annotated locations for NP_001238936.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks multiple exons and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL163051, BX089817, BX161482, DB045100
    Consensus CDS
    CCDS58335.1
    UniProtKB/Swiss-Prot
    P51003
    UniProtKB/TrEMBL
    A0A0C4DGK1
    Related
    ENSP00000450812.1, ENST00000557471.5
    Conserved Domains (1) summary
    cl11966
    Location:21205
    NT_Pol-beta-like; Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins
  3. NM_001293627.1NP_001280556.1  poly(A) polymerase alpha isoform 4

    See identical proteins and their annotated locations for NP_001280556.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (4) lacks an internal aa, compared to isoform 1.
    Source sequence(s)
    BC015150, BC036014, CD655865, DB483858
    UniProtKB/Swiss-Prot
    P51003
    Conserved Domains (2) summary
    pfam04926
    Location:366495
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:21363
    PAP_central; Poly(A) polymerase central domain
  4. NM_001293628.2NP_001280557.1  poly(A) polymerase alpha isoform 5

    See identical proteins and their annotated locations for NP_001280557.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has an alternate 5' terminal exon, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (5) has a shorter N-terminus, compared to isoform 1. Both variants 5 and 6 encode the same isoform 5.
    Source sequence(s)
    AL163051, BC036014, BX248301, CD655865
    UniProtKB/Swiss-Prot
    P51003
    UniProtKB/TrEMBL
    A0A024R6J7
    Conserved Domains (3) summary
    cl11966
    Location:1113
    NT_Pol-beta-like; Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins
    cl26091
    Location:251396
    MotB_plug; Membrane MotB of proton-channel complex MotA/MotB
    cl27098
    Location:1317
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
  5. NM_001293632.3NP_001280561.1  poly(A) polymerase alpha isoform 5

    See identical proteins and their annotated locations for NP_001280561.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks two consecutive exons in the 5' region, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (5) has a shorter N-terminus, compared to isoform 1. Both variants 5 and 6 encode the same isoform 5.
    Source sequence(s)
    AK307659, AL163051, BC036014, DB483858
    UniProtKB/Swiss-Prot
    P51003
    UniProtKB/TrEMBL
    A0A024R6J7
    Conserved Domains (3) summary
    cl11966
    Location:1113
    NT_Pol-beta-like; Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins
    cl26091
    Location:251396
    MotB_plug; Membrane MotB of proton-channel complex MotA/MotB
    cl27098
    Location:1317
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
  6. NM_001363662.3NP_001350591.1  poly(A) polymerase alpha isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL163051
    Consensus CDS
    CCDS86431.1
    Related
    ENSP00000376716.2, ENST00000392990.6
    Conserved Domains (3) summary
    PRK12799
    Location:501646
    motB; flagellar motor protein MotB; Reviewed
    pfam04926
    Location:366495
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:21363
    PAP_central; Poly(A) polymerase central domain
  7. NM_001363664.3NP_001350593.1  poly(A) polymerase alpha isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL163051
    Conserved Domains (3) summary
    pfam04926
    Location:366495
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:21363
    PAP_central; Poly(A) polymerase central domain
    cl26091
    Location:501645
    MotB_plug; Membrane MotB of proton-channel complex MotA/MotB
  8. NM_001363665.3NP_001350594.1  poly(A) polymerase alpha isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL163051
    Conserved Domains (3) summary
    PRK12799
    Location:501646
    motB; flagellar motor protein MotB; Reviewed
    pfam04926
    Location:366495
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:21363
    PAP_central; Poly(A) polymerase central domain
  9. NM_001363666.3NP_001350595.1  poly(A) polymerase alpha isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL163051
    Conserved Domains (3) summary
    pfam04926
    Location:366495
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:21363
    PAP_central; Poly(A) polymerase central domain
    cl26091
    Location:501645
    MotB_plug; Membrane MotB of proton-channel complex MotA/MotB
  10. NM_032632.5NP_116021.2  poly(A) polymerase alpha isoform 1

    See identical proteins and their annotated locations for NP_116021.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL163051
    Consensus CDS
    CCDS9946.1
    UniProtKB/Swiss-Prot
    P51003
    UniProtKB/TrEMBL
    A0A024R6M3
    Related
    ENSP00000216277.8, ENST00000216277.13
    Conserved Domains (3) summary
    PRK12799
    Location:501646
    motB; flagellar motor protein MotB; Reviewed
    pfam04926
    Location:366495
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:21363
    PAP_central; Poly(A) polymerase central domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    96502376..96567116
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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