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Papola poly (A) polymerase alpha [ Mus musculus (house mouse) ]

Gene ID: 18789, updated on 2-Nov-2024

Summary

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Official Symbol
Papolaprovided by MGI
Official Full Name
poly (A) polymerase alphaprovided by MGI
Primary source
MGI:MGI:109301
See related
Ensembl:ENSMUSG00000021111 AllianceGenome:MGI:109301
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pap; Plap; PapIII
Summary
Enables poly(A) RNA polymerase activity. Acts upstream of or within cytosolic mRNA polyadenylation. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PAPOLA (poly(A) polymerase alpha). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 35.7), limb E14.5 (RPKM 31.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Papola in Genome Data Viewer
Location:
12 E; 12 56.06 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (105750926..105805208)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (105784677..105838949)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene GSK3B interacting protein Neighboring gene adenylate kinase 7 Neighboring gene STARR-seq mESC enhancer starr_33192 Neighboring gene STARR-seq mESC enhancer starr_33193 Neighboring gene STARR-seq mESC enhancer starr_33194 Neighboring gene STARR-seq mESC enhancer starr_33197 Neighboring gene predicted gene, 19554 Neighboring gene predicted gene, 32370 Neighboring gene STARR-seq mESC enhancer starr_33198 Neighboring gene VISTA enhancer mm1604 Neighboring gene STARR-positive B cell enhancer ABC_E7178 Neighboring gene STARR-positive B cell enhancer ABC_E3067 Neighboring gene vaccinia related kinase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulation of spermatogenesis by testis-specific, cytoplasmic poly(A) polymerase TPAP. Kashiwabara S, et al. Science, 2002 Dec 6. PMID 12471261
  2. Complex alternative RNA processing generates an unexpected diversity of poly(A) polymerase isoforms. Zhao W, et al. Mol Cell Biol, 1996 May. PMID 8628305, Free PMC Article
  3. Interaction of poly(A) polymerase with the 25-kDa subunit of cleavage factor I. Kim H, et al. Biochem Biophys Res Commun, 2001 Nov 30. PMID 11716503
  4. ERK is a novel regulatory kinase for poly(A) polymerase. Lee SH, et al. Nucleic Acids Res, 2008 Feb. PMID 18084034, Free PMC Article
  5. Inositol 1,4,5-triphosphate receptor-binding protein released with inositol 1,4,5-triphosphate (IRBIT) associates with components of the mRNA 3' processing machinery in a phosphorylation-dependent manner and inhibits polyadenylation. Kiefer H, et al. J Biol Chem, 2009 Apr 17. PMID 19224921, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables manganese ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables poly(A) RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(A) RNA polymerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables poly(A) RNA polymerase activity ISO
Inferred from Sequence Orthology
more info
  
enables poly(A) RNA polymerase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within cytosolic mRNA polyadenylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
poly(A) polymerase alpha
Names
PAP-alpha
polynucleotide adenylyltransferase
NP_001334369.1
NP_001409830.1
NP_035242.1
XP_006515655.1
XP_006515656.1
XP_006515657.1
XP_006515658.1
XP_006515659.1
XP_017170481.1
XP_017170483.1
XP_030102471.1
XP_030102472.1
XP_030102473.1
XP_036013145.1
XP_036013146.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347440.1 → NP_001334369.1  poly(A) polymerase alpha isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is shorter than isoform 1.
    Source sequence(s)
    AC158526, AK132704, BC060128, BU056874, BY308303, CF167932, CX200364
    Consensus CDS
    CCDS84000.1
    UniProtKB/TrEMBL
    E9PWC8, E9PZR3
    Related
    ENSMUSP00000126275.2, ENSMUST00000170002.8
    Conserved Domains (3) summary
    PRK12799
    Location:501 → 647
    motB; flagellar motor protein MotB; Reviewed
    pfam04926
    Location:366 → 495
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:21 → 363
    PAP_central; Poly(A) polymerase central domain

  2. NM_001422901.1 → NP_001409830.1  poly(A) polymerase alpha isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC144543, AC158526

  3. NM_011112.4 → NP_035242.1  poly(A) polymerase alpha isoform 1

    See identical proteins and their annotated locations for NP_035242.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC158526, AK132704, BC060128, BU056874, BY308303, CX200364
    Consensus CDS
    CCDS49163.1
    UniProtKB/Swiss-Prot
    Q61183, Q61208, Q61209, Q8K4X2
    UniProtKB/TrEMBL
    Q3V141
    Related
    ENSMUSP00000105527.3, ENSMUST00000109901.9
    Conserved Domains (3) summary
    pfam04926
    Location:366 → 495
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:21 → 363
    PAP_central; Poly(A) polymerase central domain
    cl25496
    Location:530 → 725
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

RNA

  1. NR_186615.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC144543, AC158526
    Related
    ENSMUST00000169938.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    105750926..105805208
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314994.3 → XP_017170483.1  poly(A) polymerase alpha isoform X7

    UniProtKB/TrEMBL
    E9PWC8
    Conserved Domains (3) summary
    PRK12799
    Location:501 → 646
    motB; flagellar motor protein MotB; Reviewed
    pfam04926
    Location:366 → 495
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:21 → 363
    PAP_central; Poly(A) polymerase central domain

  2. XM_017314992.3 → XP_017170481.1  poly(A) polymerase alpha isoform X2

    UniProtKB/TrEMBL
    Q3V141
    Conserved Domains (3) summary
    PRK12799
    Location:501 → 646
    motB; flagellar motor protein MotB; Reviewed
    pfam04926
    Location:366 → 495
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:21 → 363
    PAP_central; Poly(A) polymerase central domain

  3. XM_036157252.1 → XP_036013145.1  poly(A) polymerase alpha isoform X11

    UniProtKB/TrEMBL
    F6VTN8
    Conserved Domains (3) summary
    PRK12799
    Location:251 → 397
    motB; flagellar motor protein MotB; Reviewed
    PTZ00418
    Location:1 → 317
    PTZ00418; Poly(A) polymerase; Provisional
    cl11966
    Location:1 → 113
    NT_Pol-beta-like; Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins

  4. XM_030246613.1 → XP_030102473.1  poly(A) polymerase alpha isoform X12

    UniProtKB/TrEMBL
    F6VTN8
    Related
    ENSMUSP00000132353.2, ENSMUST00000166471.8
    Conserved Domains (2) summary
    PRK12799
    Location:205 → 345
    motB; flagellar motor protein MotB; Reviewed
    PTZ00418
    Location:2 → 265
    PTZ00418; Poly(A) polymerase; Provisional

  5. XM_036157253.1 → XP_036013146.1  poly(A) polymerase alpha isoform X13

    UniProtKB/TrEMBL
    F6VTN8
    Conserved Domains (2) summary
    PRK12799
    Location:205 → 345
    motB; flagellar motor protein MotB; Reviewed
    PTZ00418
    Location:2 → 265
    PTZ00418; Poly(A) polymerase; Provisional

  6. XM_006515596.4 → XP_006515659.1  poly(A) polymerase alpha isoform X9

    UniProtKB/TrEMBL
    Q3V141
    Conserved Domains (3) summary
    pfam05109
    Location:544 → 739
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam04926
    Location:380 → 509
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:35 → 377
    PAP_central; Poly(A) polymerase central domain

  7. XM_030246611.2 → XP_030102471.1  poly(A) polymerase alpha isoform X4

    UniProtKB/TrEMBL
    E9PWC8
    Conserved Domains (3) summary
    PRK12799
    Location:515 → 660
    motB; flagellar motor protein MotB; Reviewed
    pfam04926
    Location:380 → 509
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:35 → 377
    PAP_central; Poly(A) polymerase central domain

  8. XM_006515594.4 → XP_006515657.1  poly(A) polymerase alpha isoform X5

    UniProtKB/TrEMBL
    E9QAN2
    Conserved Domains (3) summary
    PRK12799
    Location:515 → 661
    motB; flagellar motor protein MotB; Reviewed
    pfam04926
    Location:380 → 509
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:35 → 377
    PAP_central; Poly(A) polymerase central domain

  9. XM_030246612.2 → XP_030102472.1  poly(A) polymerase alpha isoform X6

    UniProtKB/TrEMBL
    E9QAN2
    Conserved Domains (3) summary
    PRK12799
    Location:515 → 660
    motB; flagellar motor protein MotB; Reviewed
    pfam04926
    Location:380 → 509
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:35 → 377
    PAP_central; Poly(A) polymerase central domain

  10. XM_006515593.5 → XP_006515656.1  poly(A) polymerase alpha isoform X3

    UniProtKB/TrEMBL
    E9PWC8
    Conserved Domains (3) summary
    PRK12799
    Location:515 → 661
    motB; flagellar motor protein MotB; Reviewed
    pfam04926
    Location:380 → 509
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:35 → 377
    PAP_central; Poly(A) polymerase central domain

  11. XM_006515592.4 → XP_006515655.1  poly(A) polymerase alpha isoform X1

    UniProtKB/TrEMBL
    Q3V141
    Conserved Domains (3) summary
    PRK12799
    Location:515 → 660
    motB; flagellar motor protein MotB; Reviewed
    pfam04926
    Location:380 → 509
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:35 → 377
    PAP_central; Poly(A) polymerase central domain

  12. XM_006515595.4 → XP_006515658.1  poly(A) polymerase alpha isoform X8

    UniProtKB/TrEMBL
    E9QAN2
    Conserved Domains (3) summary
    PRK12799
    Location:515 → 661
    motB; flagellar motor protein MotB; Reviewed
    pfam04926
    Location:380 → 509
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:35 → 377
    PAP_central; Poly(A) polymerase central domain

RNA

  1. XR_003949999.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61183.4 GenPept UniProtKB/Swiss-Prot:Q61183

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