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LILRB1 leukocyte immunoglobulin like receptor B1 [ Homo sapiens (human) ]

Gene ID: 10859, updated on 8-Jul-2021

Summary

Official Symbol
LILRB1provided by HGNC
Official Full Name
leukocyte immunoglobulin like receptor B1provided by HGNC
Primary source
HGNC:HGNC:6605
See related
Ensembl:ENSG00000104972 MIM:604811
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ILT2; LIR1; MIR7; PIRB; CD85J; ILT-2; LIR-1; MIR-7; PIR-B
Summary
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in appendix (RPKM 25.9), spleen (RPKM 20.5) and 10 other tissues See more
Orthologs
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Genomic context

See LILRB1 in Genome Data Viewer
Location:
19q13.42
Exon count:
17
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (54616322..54638022)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55128583..55149007)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene leukocyte immunoglobulin like receptor A2 Neighboring gene leukocyte immunoglobulin like receptor A1 Neighboring gene microRNA 8061 Neighboring gene vomeronasal 1 receptor 105 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of leukocyte immunoglobulin-like receptor, subfamily B, member 1 (LILRB1) in human B cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37515

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in Fc receptor mediated inhibitory signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in T cell proliferation involved in immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dendritic cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in immune response-inhibiting cell surface receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of CD8-positive, alpha-beta T cell activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of T cell mediated cytotoxicity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of alpha-beta T cell activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cytokine production involved in immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of dendritic cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of dendritic cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of interferon-beta production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of interferon-gamma production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of interleukin-10 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of interleukin-12 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of mononuclear cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of natural killer cell mediated cytotoxicity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of osteoclast development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of serotonin secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transforming growth factor beta production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of defense response to virus by host IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gamma-delta T cell activation involved in immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interferon-gamma production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of macrophage cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
involved_in receptor internalization TAS
Traceable Author Statement
more info
PubMed 
involved_in response to virus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
leukocyte immunoglobulin-like receptor subfamily B member 1
Names
CD85 antigen-like family member J
Ig-like transcript 2
immunoglobulin heavy chain variable region
leucocyte Ig-like receptor B1
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
monocyte/macrophage immunoglobulin-like receptor 7
myeloid inhibitory receptor 7

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081637.3NP_001075106.2  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a shorter 5' UTR and uses two alternate in-frame splice sites in the coding region, compared to variant 1. The resulting protein (isoform 2) is longer, compared to isoform 1.
    Source sequence(s)
    AC245036
    Consensus CDS
    CCDS42614.1
    UniProtKB/Swiss-Prot
    Q8NHL6
    UniProtKB/TrEMBL
    A0A087WSV6
    Related
    ENSP00000315997.7, ENST00000324602.12
    Conserved Domains (3) summary
    cd00096
    Location:125129
    Ig; Ig strand A [structural motif]
    cd05751
    Location:28118
    IgC2_D1_LILR_KIR_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains
    cl11960
    Location:124219
    Ig; Immunoglobulin domain
  2. NM_001081638.4NP_001075107.2  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region and differs in the 5' UTR, compared to variant 1. The resulting protein (isoform 3) is longer, compared to isoform 1.
    Source sequence(s)
    AF283984, AK223310, BC015731, DQ655953, EU915608
    Consensus CDS
    CCDS42615.1
    UniProtKB/Swiss-Prot
    Q8NHL6
    UniProtKB/TrEMBL
    A0A087WSX8
    Related
    ENSP00000379618.3, ENST00000396327.7
    Conserved Domains (3) summary
    cd00096
    Location:125129
    Ig; Ig strand A [structural motif]
    cd05751
    Location:28118
    IgC2_D1_LILR_KIR_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains
    cl11960
    Location:124219
    Ig; Immunoglobulin domain
  3. NM_001081639.4NP_001075108.2  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001075108.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region and differs in the 5' UTR, compared to variant 1. The resulting protein (isoform 4) is longer, compared to isoform 1.
    Source sequence(s)
    AF004230, AF283984, AK223310, BC015731, DQ655953, EU915608
    Consensus CDS
    CCDS42616.1
    UniProtKB/Swiss-Prot
    Q8NHL6
    UniProtKB/TrEMBL
    D9IDM5
    Related
    ENSP00000379623.4, ENST00000396332.8
    Conserved Domains (3) summary
    cd00096
    Location:125129
    Ig; Ig strand A [structural motif]
    cd05751
    Location:28118
    IgC2_D1_LILR_KIR_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains
    cl11960
    Location:124219
    Ig; Immunoglobulin domain
  4. NM_001278398.2NP_001265327.2  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has a shorter 5' UTR, lacks an internal in-frame exon, and uses an alternate splice site in the central coding region, compared to variant 1. The resulting protein (isoform 5) is shorter, compared to isoform 1.
    Source sequence(s)
    AF009006, AF283984, BC015731, EU915608
    Consensus CDS
    CCDS62803.1
    UniProtKB/Swiss-Prot
    Q8NHL6
    UniProtKB/TrEMBL
    A8MVE2
    Related
    ENSP00000379610.1, ENST00000396317.5
    Conserved Domains (3) summary
    cd05751
    Location:27119
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
    smart00410
    Location:335397
    IG_like; Immunoglobulin like
    cl11960
    Location:124219
    Ig; Immunoglobulin domain
  5. NM_001278399.2NP_001265328.2  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 6 precursor

    See identical proteins and their annotated locations for NP_001265328.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has a shorter 5' UTR, lacks several exons, and its 3'-terminal exon extends past a splice site that is used in variant 1. The resulting protein (isoform 6) has a shorter and distinct C-terminus, compared to isoform 1. Isoform 6 lacks the transmembrane domain found in isoform 1 and is suspected to be soluble (PMID: 19658091).
    Source sequence(s)
    AK223310, DA991480, EU915608
    UniProtKB/Swiss-Prot
    Q8NHL6
    Conserved Domains (3) summary
    cd05751
    Location:27119
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
    smart00410
    Location:335397
    IG_like; Immunoglobulin like
    cl11960
    Location:124219
    Ig; Immunoglobulin domain
  6. NM_001388355.1NP_001375284.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC245036
    Conserved Domains (3) summary
    cd00096
    Location:125129
    Ig; Ig strand A [structural motif]
    cd05751
    Location:28118
    IgC2_D1_LILR_KIR_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains
    cl11960
    Location:124219
    Ig; Immunoglobulin domain
  7. NM_001388356.1NP_001375285.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AC245036
    Conserved Domains (3) summary
    cd00096
    Location:125129
    Ig; Ig strand A [structural motif]
    cd05751
    Location:28118
    IgC2_D1_LILR_KIR_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains
    cl11960
    Location:124219
    Ig; Immunoglobulin domain
  8. NM_001388357.1NP_001375286.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC245036
    Conserved Domains (3) summary
    cd00096
    Location:125129
    Ig; Ig strand A [structural motif]
    cd05751
    Location:28118
    IgC2_D1_LILR_KIR_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains
    cl11960
    Location:124219
    Ig; Immunoglobulin domain
  9. NM_001388358.1NP_001375287.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC245036
    Conserved Domains (3) summary
    cd00096
    Location:125129
    Ig; Ig strand A [structural motif]
    cd05751
    Location:28118
    IgC2_D1_LILR_KIR_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains
    cl11960
    Location:124219
    Ig; Immunoglobulin domain
  10. NM_006669.7NP_006660.4  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_006660.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AF283984, AK223310, AK292156, BC015731
    Consensus CDS
    CCDS42617.1
    UniProtKB/Swiss-Prot
    Q8NHL6
    UniProtKB/TrEMBL
    A0A0B4J1W1
    Related
    ENSP00000379622.1, ENST00000396331.5
    Conserved Domains (3) summary
    cd05751
    Location:27119
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
    smart00410
    Location:335397
    IG_like; Immunoglobulin like
    cl11960
    Location:124219
    Ig; Immunoglobulin domain

RNA

  1. NR_103518.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has a shorter 5' UTR and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF283984, AK223310, BC015731

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    54616322..54638022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026192.1XP_016881681.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X14

  2. XM_011526331.2XP_011524633.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X1

    Conserved Domains (3) summary
    cd05751
    Location:27119
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
    smart00410
    Location:345407
    IG_like; Immunoglobulin like
    cl11960
    Location:124219
    Ig; Immunoglobulin domain
  3. XM_011526335.2XP_011524637.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X11

    Conserved Domains (3) summary
    cd05751
    Location:27119
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
    smart00410
    Location:345407
    IG_like; Immunoglobulin like
    cl11960
    Location:124219
    Ig; Immunoglobulin domain
  4. XM_017026191.1XP_016881680.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X12

  5. XM_011526336.2XP_011524638.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X13

    Related
    ENSP00000410165.1, ENST00000421584.5
    Conserved Domains (3) summary
    cd05751
    Location:27119
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
    smart00410
    Location:335397
    IG_like; Immunoglobulin like
    cl11960
    Location:124219
    Ig; Immunoglobulin domain
  6. XM_011526332.3XP_011524634.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X3

    Conserved Domains (3) summary
    cd05751
    Location:27119
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
    smart00410
    Location:345407
    IG_like; Immunoglobulin like
    cl11960
    Location:124219
    Ig; Immunoglobulin domain
  7. XM_017026184.2XP_016881673.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X5

  8. XM_017026182.2XP_016881671.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X2

    Related
    ENSP00000395004.2, ENST00000427581.6
  9. XM_017026183.2XP_016881672.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X4

  10. XM_017026185.1XP_016881674.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X6

    UniProtKB/TrEMBL
    A0A0B4J1W1
    Conserved Domains (3) summary
    cd05751
    Location:27119
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
    smart00410
    Location:335397
    IG_like; Immunoglobulin like
    cl11960
    Location:124219
    Ig; Immunoglobulin domain

RNA

  1. XR_001753590.2 RNA Sequence

  2. XR_002958244.1 RNA Sequence

  3. XR_001753591.1 RNA Sequence

  4. XR_935716.2 RNA Sequence

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NW_003571054.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    522708..544408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_7

Genomic

  1. NW_003571060.1 Reference GRCh38.p13 ALT_REF_LOCI_7

    Range
    521195..542900
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_9

Genomic

  1. NT_187693.1 Reference GRCh38.p13 ALT_REF_LOCI_9

    Range
    598890..620587
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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