LILRB1 leukocyte immunoglobulin like receptor B1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LILRB1provided by HGNC
Official Full Name: leukocyte immunoglobulin like receptor B1provided by HGNC
Primary source: HGNC:HGNC:6605
See related: Ensembl:ENSG00000104972 MIM:604811; AllianceGenome:HGNC:6605
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ILT2; LIR1; MIR7; PIRB; CD85J; ILT-2; LIR-1; MIR-7; PIR-B
Summary: This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Biased expression in appendix (RPKM 25.9), spleen (RPKM 20.5) and 10 other tissues See more
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 19q13.42

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (54616322..54638022)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (57709827..57731530)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (55127776..55149473)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LILRB1-HLA-G axis defines a checkpoint driving natural killer cell exhaustion in tuberculosis.
Title: LILRB1-HLA-G axis defines a checkpoint driving natural killer cell exhaustion in tuberculosis.
Leukocyte immunoglobulin-like receptor B1 (LILRB1) protects human multiple myeloma cells from ferroptosis by maintaining cholesterol homeostasis.
Title: Leukocyte immunoglobulin-like receptor B1 (LILRB1) protects human multiple myeloma cells from ferroptosis by maintaining cholesterol homeostasis.
ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms.
Title: ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms.
HLA-F and LILRB1 Genetic Polymorphisms Associated with Alloimmunisation in Sickle Cell Disease.
Title: HLA-F and LILRB1 Genetic Polymorphisms Associated with Alloimmunisation in Sickle Cell Disease.
Peripheral HLA-G/ILT-2 immune checkpoint axis in acute and convalescent COVID-19 patients.
Title: Peripheral HLA-G/ILT-2 immune checkpoint axis in acute and convalescent COVID-19 patients.
EIF4A3-induced circular RNA SCAP facilitates tumorigenesis and progression of non-small-cell lung cancer via miR-7/SMAD2 signaling.
Title: EIF4A3-induced circular RNA SCAP facilitates tumorigenesis and progression of non-small-cell lung cancer via miR-7/SMAD2 signaling.
Elevated LILRB1 expression predicts poor prognosis and is associated with tumor immune infiltration in patients with glioma.
Title: Elevated LILRB1 expression predicts poor prognosis and is associated with tumor immune infiltration in patients with glioma.
TET2 and LILRB1 mutations are frequent in Epstein-Barr virus-positive diffuse large B-cell lymphoma especially in elderly patients.
Title: TET2 and LILRB1 mutations are frequent in Epstein-Barr virus-positive diffuse large B-cell lymphoma especially in elderly patients.
Evidence for Epistatic Interaction between HLA-G and LILRB1 in the Pathogenesis of Nonsegmental Vitiligo.
Title: Evidence for Epistatic Interaction between HLA-G and LILRB1 in the Pathogenesis of Nonsegmental Vitiligo.
Uterine NK cells underexpress KIR2DL1/S1 and LILRB1 in reproductive failure.
Title: Uterine NK cells underexpress KIR2DL1/S1 and LILRB1 in reproductive failure.

Submit: New GeneRIF Correction See all GeneRIFs (119)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 downregulates the expression of leukocyte immunoglobulin-like receptor, subfamily B, member 1 (LILRB1) in human B cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

REN92234 (e-PCR)
- UniSTS:417032

REN92235 (e-PCR)
- UniSTS:417033

ECD16466 (e-PCR)
- UniSTS:297481

REN92236 (e-PCR)
- UniSTS:417034

REN92238 (e-PCR)
- UniSTS:417036

REN92239 (e-PCR)
- UniSTS:417037

ECD10050 (e-PCR)
- UniSTS:291090

ECD18786 (e-PCR)
- UniSTS:299796

ECD00782 (e-PCR)
- UniSTS:281891

REN93557 (e-PCR)
- UniSTS:418355

REN93558 (e-PCR)
- UniSTS:418356

REN93559 (e-PCR)
- UniSTS:418357

REN93560 (e-PCR)
- UniSTS:418358

REN93561 (e-PCR)
- UniSTS:418359

REN93562 (e-PCR)
- UniSTS:418360

REN93563 (e-PCR)
- UniSTS:418361

REN93564 (e-PCR)
- UniSTS:418362

REN93565 (e-PCR)
- UniSTS:418363

REN93566 (e-PCR)
- UniSTS:418364

REN93567 (e-PCR)
- UniSTS:418365

REN93568 (e-PCR)
- UniSTS:418366

REN93569 (e-PCR)
- UniSTS:418367

ECD04689 (e-PCR)
- UniSTS:285760

REN93570 (e-PCR)
- UniSTS:418368

REN93571 (e-PCR)
- UniSTS:418369

REN93572 (e-PCR)
- UniSTS:418370

REN93573 (e-PCR)
- UniSTS:418371

stSG605948 (e-PCR)
- UniSTS:448067

REN93574 (e-PCR)
- UniSTS:418372

REN93575 (e-PCR)
- UniSTS:418373

REN93576 (e-PCR)
- UniSTS:418374

REN93577 (e-PCR)
- UniSTS:418375

REN93578 (e-PCR)
- UniSTS:418376

REN93579 (e-PCR)
- UniSTS:418377

REN93580 (e-PCR)
- UniSTS:418378

REN93581 (e-PCR)
- UniSTS:418379

REN93582 (e-PCR)
- UniSTS:418380

REN93583 (e-PCR)
- UniSTS:418381

REN93584 (e-PCR)
- UniSTS:418382

REN93585 (e-PCR)
- UniSTS:418383

REN93586 (e-PCR)
- UniSTS:418384

REN93587 (e-PCR)
- UniSTS:418385

REN93588 (e-PCR)
- UniSTS:418386

REN93589 (e-PCR)
- UniSTS:418387

REN93590 (e-PCR)
- UniSTS:418388

REN93591 (e-PCR)
- UniSTS:418389

REN93592 (e-PCR)
- UniSTS:418390

REN93593 (e-PCR)
- UniSTS:418391

REN93594 (e-PCR)
- UniSTS:418392

REN93595 (e-PCR)
- UniSTS:418393

REN93596 (e-PCR)
- UniSTS:418394

REN93597 (e-PCR)
- UniSTS:418395

REN93598 (e-PCR)
- UniSTS:418396

REN93599 (e-PCR)
- UniSTS:418397

REN93600 (e-PCR)
- UniSTS:418398

REN93602 (e-PCR)
- UniSTS:418400

REN93603 (e-PCR)
- UniSTS:418401

REN93604 (e-PCR)
- UniSTS:418402

REN93605 (e-PCR)
- UniSTS:418403

REN93606 (e-PCR)
- UniSTS:418404

REN93607 (e-PCR)
- UniSTS:418405

REN93608 (e-PCR)
- UniSTS:418406

REN93609 (e-PCR)
- UniSTS:418407

REN93610 (e-PCR)
- UniSTS:418408

REN93611 (e-PCR)
- UniSTS:418409

REN93613 (e-PCR)
- UniSTS:418411

ECD00082 (e-PCR)
- UniSTS:281196

REN93614 (e-PCR)
- UniSTS:418412

REN93615 (e-PCR)
- UniSTS:418413

REN93616 (e-PCR)
- UniSTS:418414

REN93617 (e-PCR)
- UniSTS:418415

REN93618 (e-PCR)
- UniSTS:418416

REN93619 (e-PCR)
- UniSTS:418417

REN93620 (e-PCR)
- UniSTS:418418

REN93621 (e-PCR)
- UniSTS:418419

REN93622 (e-PCR)
- UniSTS:418420

REN93623 (e-PCR)
- UniSTS:418421

REN93624 (e-PCR)
- UniSTS:418422

REN93625 (e-PCR)
- UniSTS:418423

REN93626 (e-PCR)
- UniSTS:418424

REN93627 (e-PCR)
- UniSTS:418425

REN93628 (e-PCR)
- UniSTS:418426

ECD11182 (e-PCR)
- UniSTS:292218

REN93629 (e-PCR)
- UniSTS:418427

REN93630 (e-PCR)
- UniSTS:418428

REN93631 (e-PCR)
- UniSTS:418429

REN93632 (e-PCR)
- UniSTS:418430

REN93634 (e-PCR)
- UniSTS:418432

REN93635 (e-PCR)
- UniSTS:418433

REN93636 (e-PCR)
- UniSTS:418434

REN93637 (e-PCR)
- UniSTS:418435

REN93638 (e-PCR)
- UniSTS:418436

REN93639 (e-PCR)
- UniSTS:418437

REN93640 (e-PCR)
- UniSTS:418438

REN93641 (e-PCR)
- UniSTS:418439

REN93642 (e-PCR)
- UniSTS:418440

REN93643 (e-PCR)
- UniSTS:418441

REN93644 (e-PCR)
- UniSTS:418442

REN93645 (e-PCR)
- UniSTS:418443

REN93646 (e-PCR)
- UniSTS:418444

REN93647 (e-PCR)
- UniSTS:418445

REN93648 (e-PCR)
- UniSTS:418446

REN93649 (e-PCR)
- UniSTS:418447

REN93650 (e-PCR)
- UniSTS:418448

REN93651 (e-PCR)
- UniSTS:418449

REN93652 (e-PCR)
- UniSTS:418450

REN93653 (e-PCR)
- UniSTS:418451

ECD22004 (e-PCR)
- UniSTS:302995

REN93654 (e-PCR)
- UniSTS:418452

REN93655 (e-PCR)
- UniSTS:418453

RH70709 (e-PCR)
- UniSTS:48548

ECD12015 (e-PCR)
- UniSTS:293048

ECD12535 (e-PCR)
- UniSTS:293568

ECD19993 (e-PCR)
- UniSTS:300997

REN93455 (e-PCR)
- UniSTS:418253

REN93456 (e-PCR)
- UniSTS:418254

REN92192 (e-PCR)
- UniSTS:416990

REN92194 (e-PCR)
- UniSTS:416992

REN92195 (e-PCR)
- UniSTS:416993

REN92212 (e-PCR)
- UniSTS:417010

REN92217 (e-PCR)
- UniSTS:417015

REN92218 (e-PCR)
- UniSTS:417016

REN92219 (e-PCR)
- UniSTS:417017

ECD01260 (e-PCR)
- UniSTS:282367

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables HLA-A specific inhibitory MHC class I receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables HLA-B specific inhibitory MHC class I receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables MHC class I protein binding	IDA Inferred from Direct Assay more info	PubMed
enables MHC class I protein binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables MHC class I protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables MHC class I receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables MHC class Ib protein binding	IDA Inferred from Direct Assay more info	PubMed
enables MHC class Ib protein complex binding	IDA Inferred from Direct Assay more info	PubMed
enables MHC class Ib receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables SH2 domain binding	IDA Inferred from Direct Assay more info	PubMed
NOT enables amyloid-beta binding	IDA Inferred from Direct Assay more info	PubMed
enables inhibitory MHC class I receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase 1 binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Fc receptor mediated inhibitory signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in T cell proliferation involved in immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in defense response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in dendritic cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in immune response-inhibiting cell surface receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in immune response-regulating signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in interleukin-10-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of CD8-positive, alpha-beta T cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of T cell mediated cytotoxicity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of alpha-beta T cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cytokine production involved in immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of dendritic cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of dendritic cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of interferon-beta production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of interleukin-10 production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of interleukin-12 production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of mononuclear cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of natural killer cell mediated cytotoxicity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of osteoclast development	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of serotonin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transforming growth factor beta production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of tumor necrosis factor production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of type II interferon production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of defense response to virus by host	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gamma-delta T cell activation involved in immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of macrophage cytokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of type II interferon production	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor internalization	TAS Traceable Author Statement more info	PubMed
involved_in response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

Go to the top of the page Help

Preferred Names: leukocyte immunoglobulin-like receptor subfamily B member 1

Names: CD85 antigen-like family member J; Ig-like transcript 2; immunoglobulin heavy chain variable region; leucocyte Ig-like receptor B1; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1; monocyte/macrophage immunoglobulin-like receptor 7; myeloid inhibitory receptor 7

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081637.3 → NP_001075106.2 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) has a shorter 5' UTR and uses two alternate in-frame splice sites in the coding region, compared to variant 1. The resulting protein (isoform 2) is longer, compared to isoform 1.

Source sequence(s)

AC245036

Consensus CDS

CCDS42614.1

UniProtKB/TrEMBL

A0A087WSV6, A0A0G2JNQ6

Related

ENSP00000315997.7, ENST00000324602.12

Conserved Domains (3) summary

cd00096
Location:125 → 129

Ig; Ig strand A [structural motif]

cd05751
Location:28 → 118

IgC2_D1_LILR_KIR_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains

cl11960
Location:124 → 219

Ig; Immunoglobulin domain
NM_001081638.4 → NP_001075107.2 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 3 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region and differs in the 5' UTR, compared to variant 1. The resulting protein (isoform 3) is longer, compared to isoform 1.

Source sequence(s)

AF283984, AK223310, BC015731, DQ655953, EU915608

Consensus CDS

CCDS42615.1

UniProtKB/TrEMBL

A0A087WSX8, A0A0G2JQ44

Related

ENSP00000379618.3, ENST00000396327.7

Conserved Domains (3) summary

cd00096
Location:125 → 129

Ig; Ig strand A [structural motif]

cd05751
Location:28 → 118

IgC2_D1_LILR_KIR_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains

cl11960
Location:124 → 219

Ig; Immunoglobulin domain
NM_001081639.4 → NP_001075108.2 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 4 precursor

See identical proteins and their annotated locations for NP_001075108.2

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region and differs in the 5' UTR, compared to variant 1. The resulting protein (isoform 4) is longer, compared to isoform 1.

Source sequence(s)

AF004230, AF283984, AK223310, BC015731, DQ655953, EU915608

Consensus CDS

CCDS42616.1

UniProtKB/TrEMBL

D9IDM5, D9IDM8

Related

ENSP00000379623.4, ENST00000396332.8

Conserved Domains (3) summary

cd00096
Location:125 → 129

Ig; Ig strand A [structural motif]

cd05751
Location:28 → 118

IgC2_D1_LILR_KIR_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains

cl11960
Location:124 → 219

Ig; Immunoglobulin domain
NM_001278398.2 → NP_001265327.2 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 5 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (5) has a shorter 5' UTR, lacks an internal in-frame exon, and uses an alternate splice site in the central coding region, compared to variant 1. The resulting protein (isoform 5) is shorter, compared to isoform 1.

Source sequence(s)

AF009006, AF283984, BC015731, EU915608

Consensus CDS

CCDS62803.1

UniProtKB/TrEMBL

A0A0G2JQ46, A8MVE2

Related

ENSP00000379610.1, ENST00000396317.5

Conserved Domains (3) summary

cd05751
Location:27 → 119

Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins

smart00410
Location:335 → 397

IG_like; Immunoglobulin like

cl11960
Location:124 → 219

Ig; Immunoglobulin domain
NM_001278399.2 → NP_001265328.2 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 6 precursor

See identical proteins and their annotated locations for NP_001265328.2

Status: REVIEWED

Description

Transcript Variant: This variant (6) has a shorter 5' UTR, lacks several exons, and its 3'-terminal exon extends past a splice site that is used in variant 1. The resulting protein (isoform 6) has a shorter and distinct C-terminus, compared to isoform 1. Isoform 6 lacks the transmembrane domain found in isoform 1 and is suspected to be soluble (PMID: 19658091).

Source sequence(s)

AK223310, DA991480, EU915608

UniProtKB/TrEMBL

F6RVM3

Conserved Domains (3) summary

cd05751
Location:27 → 119

Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins

smart00410
Location:335 → 397

IG_like; Immunoglobulin like

cl11960
Location:124 → 219

Ig; Immunoglobulin domain
NM_001388355.1 → NP_001375284.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 3 precursor

Status: REVIEWED

Source sequence(s)

AC245036

Consensus CDS

CCDS42615.1

UniProtKB/TrEMBL

A0A087WSX8, A0A0G2JQ44

Conserved Domains (3) summary

cd00096
Location:125 → 129

Ig; Ig strand A [structural motif]

cd05751
Location:28 → 118

IgC2_D1_LILR_KIR_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains

cl11960
Location:124 → 219

Ig; Immunoglobulin domain
NM_001388356.1 → NP_001375285.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 4 precursor

Status: REVIEWED

Source sequence(s)

AC245036

Consensus CDS

CCDS42616.1

UniProtKB/TrEMBL

D9IDM5, D9IDM8

Conserved Domains (3) summary

cd00096
Location:125 → 129

Ig; Ig strand A [structural motif]

cd05751
Location:28 → 118

IgC2_D1_LILR_KIR_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains

cl11960
Location:124 → 219

Ig; Immunoglobulin domain
NM_001388357.1 → NP_001375286.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 3 precursor

Status: REVIEWED

Source sequence(s)

AC245036

Consensus CDS

CCDS42615.1

UniProtKB/TrEMBL

A0A087WSX8, A0A0G2JQ44

Conserved Domains (3) summary

cd00096
Location:125 → 129

Ig; Ig strand A [structural motif]

cd05751
Location:28 → 118

IgC2_D1_LILR_KIR_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains

cl11960
Location:124 → 219

Ig; Immunoglobulin domain
NM_001388358.1 → NP_001375287.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AC245036

Consensus CDS

CCDS42614.1

UniProtKB/TrEMBL

A0A087WSV6, A0A0G2JNQ6

Conserved Domains (3) summary

cd00096
Location:125 → 129

Ig; Ig strand A [structural motif]

cd05751
Location:28 → 118

IgC2_D1_LILR_KIR_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains

cl11960
Location:124 → 219

Ig; Immunoglobulin domain
NM_006669.7 → NP_006660.4 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_006660.4

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.

Source sequence(s)

AF283984, AK223310, AK292156, BC015731

Consensus CDS

CCDS42617.1

UniProtKB/Swiss-Prot

A2IXV4, A8MXT0, O75024, O75025, Q8NHJ9, Q8NHK0, Q8NHL6

UniProtKB/TrEMBL

A0A0B4J1W1

Related

ENSP00000379622.1, ENST00000396331.5

Conserved Domains (3) summary

cd05751
Location:27 → 119

Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins

smart00410
Location:335 → 397

IG_like; Immunoglobulin like

cl11960
Location:124 → 219

Ig; Immunoglobulin domain

RNA

NR_103518.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (7) has a shorter 5' UTR and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AF283984, AK223310, BC015731

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

54616322..54638022

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047438080.1 → XP_047294036.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X1
XM_047438081.1 → XP_047294037.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X2
XM_047438082.1 → XP_047294038.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X3
XM_047438083.1 → XP_047294039.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X4
XM_047438084.1 → XP_047294040.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X5
XM_047438085.1 → XP_047294041.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X6
XM_047438086.1 → XP_047294042.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X7
XM_047438087.1 → XP_047294043.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X8
XM_017026192.2 → XP_016881681.2 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X9
XM_047438088.1 → XP_047294044.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X10

Related

ENSP00000410165.1, ENST00000421584.5
XM_047438089.1 → XP_047294045.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X11

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

NW_003571054.1 Reference GRCh38.p14 ALT_REF_LOCI_1

Range

522708..544408

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054329622.1 → XP_054185597.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X1
XM_054329623.1 → XP_054185598.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X2
XM_054329624.1 → XP_054185599.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X3
XM_054329625.1 → XP_054185600.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X4
XM_054329626.1 → XP_054185601.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X5
XM_054329627.1 → XP_054185602.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X6
XM_054329628.1 → XP_054185603.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X7
XM_054329629.1 → XP_054185604.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X8
XM_054329630.1 → XP_054185605.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X9
XM_054329631.1 → XP_054185606.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X10
XM_054329632.1 → XP_054185607.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X11

Reference GRCh38.p14 ALT_REF_LOCI_7

Genomic

NW_003571060.1 Reference GRCh38.p14 ALT_REF_LOCI_7

Range

521195..542900

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054331448.1 → XP_054187423.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X1
XM_054331449.1 → XP_054187424.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X2
XM_054331450.1 → XP_054187425.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X3
XM_054331451.1 → XP_054187426.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X4
XM_054331452.1 → XP_054187427.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X12
XM_054331453.1 → XP_054187428.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X13
XM_054331454.1 → XP_054187429.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X14
XM_054331455.1 → XP_054187430.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X5
XM_054331457.1 → XP_054187432.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X6

UniProtKB/TrEMBL

A0A0G2JQ15
XM_054331458.1 → XP_054187433.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X7

UniProtKB/TrEMBL

A0A0G2JP64
XM_054331459.1 → XP_054187434.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X8

UniProtKB/TrEMBL

A0A0G2JNM2
XM_054331456.1 → XP_054187431.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X5
XM_054331460.1 → XP_054187435.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X9
XM_054331461.1 → XP_054187436.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X10
XM_054331462.1 → XP_054187437.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X11

Reference GRCh38.p14 ALT_REF_LOCI_9

Genomic

NT_187693.1 Reference GRCh38.p14 ALT_REF_LOCI_9

Range

598890..620587

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054333582.1 → XP_054189557.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X1
XM_054333583.1 → XP_054189558.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X2
XM_054333584.1 → XP_054189559.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X3
XM_054333585.1 → XP_054189560.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X4
XM_054333586.1 → XP_054189561.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X5
XM_054333588.1 → XP_054189563.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X6

UniProtKB/TrEMBL

A0A0G2JQ15
XM_054333589.1 → XP_054189564.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X7

UniProtKB/TrEMBL

A0A0G2JP64
XM_054333591.1 → XP_054189566.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X8

UniProtKB/TrEMBL

A0A0G2JNM2
XM_054333587.1 → XP_054189562.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X1
XM_054333590.1 → XP_054189565.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X7

UniProtKB/TrEMBL

A0A0G2JP64
XM_054333592.1 → XP_054189567.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X9
XM_054333593.1 → XP_054189568.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X10
XM_054333594.1 → XP_054189569.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X11

Alternate T2T-CHM13v2.0

Genomic

NC_060943.1 Alternate T2T-CHM13v2.0

Range

57709827..57731530

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054319577.1 → XP_054175552.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X1
XM_054319578.1 → XP_054175553.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X2
XM_054319579.1 → XP_054175554.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X3
XM_054319580.1 → XP_054175555.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X4
XM_054319581.1 → XP_054175556.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X15
XM_054319582.1 → XP_054175557.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X16
XM_054319583.1 → XP_054175558.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X17
XM_054319584.1 → XP_054175559.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X5
XM_054319587.1 → XP_054175562.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X6
XM_054319588.1 → XP_054175563.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X7
XM_054319590.1 → XP_054175565.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X8
XM_054319586.1 → XP_054175561.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X1
XM_054319585.1 → XP_054175560.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X5
XM_054319589.1 → XP_054175564.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X7
XM_054319591.1 → XP_054175566.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X9
XM_054319592.1 → XP_054175567.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X10
XM_054319593.1 → XP_054175568.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X11