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PPP1R13L protein phosphatase 1 regulatory subunit 13 like [ Homo sapiens (human) ]

Gene ID: 10848, updated on 5-Sep-2021

Summary

Official Symbol
PPP1R13Lprovided by HGNC
Official Full Name
protein phosphatase 1 regulatory subunit 13 likeprovided by HGNC
Primary source
HGNC:HGNC:18838
See related
Ensembl:ENSG00000104881 MIM:607463
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAI; RAI4; IASPP; NKIP1
Summary
IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008]
Expression
Broad expression in skin (RPKM 27.0), placenta (RPKM 6.4) and 14 other tissues See more
Orthologs
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Genomic context

See PPP1R13L in Genome Data Viewer
Location:
19q13.32
Exon count:
15
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (45379634..45406361, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (45882896..45909619, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S16 pseudogene 9 Neighboring gene kinesin light chain 3 Neighboring gene ERCC excision repair 2, TFIIH core complex helicase subunit Neighboring gene RNA polymerase I subunit G Neighboring gene ERCC excision repair 1, endonuclease non-catalytic subunit Neighboring gene Sharpr-MPRA regulatory region 13779

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cadherin binding HDA PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity TAS
Traceable Author Statement
more info
PubMed 
enables transcription factor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cardiac muscle contraction IEA
Inferred from Electronic Annotation
more info
 
involved_in cardiac right ventricle morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in embryonic camera-type eye development IEA
Inferred from Electronic Annotation
more info
 
involved_in hair cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organismal homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in post-embryonic development IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in ventricular cardiac muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell junction IDA
Inferred from Direct Assay
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
relA-associated inhibitor
Names
NFkB interacting protein 1
PPP1R13B-like protein
inhibitor of ASPP protein
inhibitor of apoptosis stimulating protein of p53
protein iASPP
protein phosphatase 1, regulatory (inhibitor) subunit 13 like
retinoic acid induced 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142502.2NP_001135974.1  relA-associated inhibitor

    See identical proteins and their annotated locations for NP_001135974.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC092309, BC064913, DB209153
    Consensus CDS
    CCDS33050.1
    UniProtKB/Swiss-Prot
    Q8WUF5
    UniProtKB/TrEMBL
    A0A024R0Q5
    Related
    ENSP00000403902.1, ENST00000418234.6
    Conserved Domains (4) summary
    cd11952
    Location:761817
    SH3_iASPP; Src Homology 3 (SH3) domain of Inhibitor of ASPP protein (iASPP)
    cd00204
    Location:626748
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:631722
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:631657
    ANK; ANK repeat [structural motif]
  2. NM_006663.4NP_006654.2  relA-associated inhibitor

    See identical proteins and their annotated locations for NP_006654.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC092309, BC032298
    Consensus CDS
    CCDS33050.1
    UniProtKB/Swiss-Prot
    Q8WUF5
    UniProtKB/TrEMBL
    A0A024R0Q5
    Related
    ENSP00000354218.4, ENST00000360957.10
    Conserved Domains (4) summary
    cd11952
    Location:761817
    SH3_iASPP; Src Homology 3 (SH3) domain of Inhibitor of ASPP protein (iASPP)
    cd00204
    Location:626748
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:631722
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:631657
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    45379634..45406361 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026178.1XP_016881667.1  relA-associated inhibitor isoform X1

    UniProtKB/Swiss-Prot
    Q8WUF5
    UniProtKB/TrEMBL
    A0A024R0Q5
    Conserved Domains (4) summary
    cd11952
    Location:761817
    SH3_iASPP; Src Homology 3 (SH3) domain of Inhibitor of ASPP protein (iASPP)
    cd00204
    Location:626748
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:631722
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:631657
    ANK; ANK repeat [structural motif]
  2. XM_017026177.1XP_016881666.1  relA-associated inhibitor isoform X1

    UniProtKB/Swiss-Prot
    Q8WUF5
    UniProtKB/TrEMBL
    A0A024R0Q5
    Conserved Domains (4) summary
    cd11952
    Location:761817
    SH3_iASPP; Src Homology 3 (SH3) domain of Inhibitor of ASPP protein (iASPP)
    cd00204
    Location:626748
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:631722
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:631657
    ANK; ANK repeat [structural motif]
  3. XM_017026179.1XP_016881668.1  relA-associated inhibitor isoform X2

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