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Ppp1r13l protein phosphatase 1, regulatory subunit 13 like [ Mus musculus (house mouse) ]

Gene ID: 333654, updated on 5-Jan-2023

Summary

Official Symbol
Ppp1r13lprovided by MGI
Official Full Name
protein phosphatase 1, regulatory subunit 13 likeprovided by MGI
Primary source
MGI:MGI:3525053
See related
Ensembl:ENSMUSG00000040734 AllianceGenome:MGI:3525053
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
wa3; IASPP; Nkip1
Summary
Predicted to enable identical protein binding activity. Acts upstream of or within several processes, including animal organ development; cardiac muscle contraction; and negative regulation of transcription by RNA polymerase II. Predicted to be located in cell junction; cytosol; and intercellular bridge. Is expressed in alimentary system; sensory organ; and vibrissa. Used to study arrhythmogenic right ventricular cardiomyopathy. Orthologous to human PPP1R13L (protein phosphatase 1 regulatory subunit 13 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 16.3), stomach adult (RPKM 11.1) and 23 other tissues See more
Orthologs
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Genomic context

See Ppp1r13l in Genome Data Viewer
Location:
7 A3; 7 9.62 cM
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (19093639..19112465)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19359724..19378540)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D830036C21 gene Neighboring gene VISTA enhancer mm567 Neighboring gene excision repair cross-complementing rodent repair deficiency, complementation group 1 Neighboring gene RNA polymerase I subunit G Neighboring gene excision repair cross-complementing rodent repair deficiency, complementation group 2 Neighboring gene microRNA 343 Neighboring gene kinesin light chain 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cardiac muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cardiac right ventricle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic camera-type eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hair cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organismal-level homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within ventricular cardiac muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
relA-associated inhibitor
Names
NFkB interacting protein 1
PPP1R13B-like protein
inhibitor of ASPP protein
protein iASPP
protein phosphatase 1, regulatory (inhibitor) subunit 13 like

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010836.3NP_001010836.1  relA-associated inhibitor

    See identical proteins and their annotated locations for NP_001010836.1

    Status: PROVISIONAL

    Source sequence(s)
    AK170535
    Consensus CDS
    CCDS20899.1
    UniProtKB/Swiss-Prot
    Q5I1X5
    UniProtKB/TrEMBL
    Q3TCU2
    Related
    ENSMUSP00000047839.8, ENSMUST00000047621.14
    Conserved Domains (4) summary
    cd11952
    Location:757813
    SH3_iASPP; Src Homology 3 (SH3) domain of Inhibitor of ASPP protein (iASPP)
    PHA03247
    Location:46364
    PHA03247; large tegument protein UL36; Provisional
    sd00045
    Location:627653
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:627713
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    19093639..19112465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540128.4XP_006540191.1  relA-associated inhibitor isoform X1

    See identical proteins and their annotated locations for XP_006540191.1

    UniProtKB/Swiss-Prot
    Q5I1X5
    UniProtKB/TrEMBL
    Q3TCU2
    Conserved Domains (4) summary
    cd11952
    Location:757813
    SH3_iASPP; Src Homology 3 (SH3) domain of Inhibitor of ASPP protein (iASPP)
    PHA03247
    Location:46364
    PHA03247; large tegument protein UL36; Provisional
    sd00045
    Location:627653
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:627713
    Ank_2; Ankyrin repeats (3 copies)
  2. XM_006540126.3XP_006540189.1  relA-associated inhibitor isoform X1

    See identical proteins and their annotated locations for XP_006540189.1

    UniProtKB/Swiss-Prot
    Q5I1X5
    UniProtKB/TrEMBL
    Q3TCU2
    Conserved Domains (4) summary
    cd11952
    Location:757813
    SH3_iASPP; Src Homology 3 (SH3) domain of Inhibitor of ASPP protein (iASPP)
    PHA03247
    Location:46364
    PHA03247; large tegument protein UL36; Provisional
    sd00045
    Location:627653
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:627713
    Ank_2; Ankyrin repeats (3 copies)
  3. XM_036153184.1XP_036009077.1  relA-associated inhibitor isoform X1

    UniProtKB/Swiss-Prot
    Q5I1X5
    UniProtKB/TrEMBL
    Q3TCU2
    Conserved Domains (4) summary
    cd11952
    Location:757813
    SH3_iASPP; Src Homology 3 (SH3) domain of Inhibitor of ASPP protein (iASPP)
    PHA03247
    Location:46364
    PHA03247; large tegument protein UL36; Provisional
    sd00045
    Location:627653
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:627713
    Ank_2; Ankyrin repeats (3 copies)
  4. XM_006540127.5XP_006540190.1  relA-associated inhibitor isoform X1

    See identical proteins and their annotated locations for XP_006540190.1

    UniProtKB/Swiss-Prot
    Q5I1X5
    UniProtKB/TrEMBL
    Q3TCU2
    Conserved Domains (4) summary
    cd11952
    Location:757813
    SH3_iASPP; Src Homology 3 (SH3) domain of Inhibitor of ASPP protein (iASPP)
    PHA03247
    Location:46364
    PHA03247; large tegument protein UL36; Provisional
    sd00045
    Location:627653
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:627713
    Ank_2; Ankyrin repeats (3 copies)
  5. XM_030242701.2XP_030098561.1  relA-associated inhibitor isoform X1

    UniProtKB/Swiss-Prot
    Q5I1X5
    UniProtKB/TrEMBL
    Q3TCU2
    Conserved Domains (4) summary
    cd11952
    Location:757813
    SH3_iASPP; Src Homology 3 (SH3) domain of Inhibitor of ASPP protein (iASPP)
    PHA03247
    Location:46364
    PHA03247; large tegument protein UL36; Provisional
    sd00045
    Location:627653
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:627713
    Ank_2; Ankyrin repeats (3 copies)
  6. XM_030242700.2XP_030098560.1  relA-associated inhibitor isoform X1

    UniProtKB/Swiss-Prot
    Q5I1X5
    UniProtKB/TrEMBL
    Q3TCU2
    Conserved Domains (4) summary
    cd11952
    Location:757813
    SH3_iASPP; Src Homology 3 (SH3) domain of Inhibitor of ASPP protein (iASPP)
    PHA03247
    Location:46364
    PHA03247; large tegument protein UL36; Provisional
    sd00045
    Location:627653
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:627713
    Ank_2; Ankyrin repeats (3 copies)