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Vps37c VPS37C subunit of ESCRT-I [ Rattus norvegicus (Norway rat) ]

Gene ID: 108348178, updated on 17-Aug-2024

Summary

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Official Symbol
Vps37cprovided by RGD
Official Full Name
VPS37C subunit of ESCRT-Iprovided by RGD
Primary source
RGD:11384366
See related
EnsemblRapid:ENSRNOG00000046439 AllianceGenome:RGD:11384366
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309258
Summary
Predicted to enable calcium-dependent protein binding activity. Predicted to be involved in protein targeting to membrane; protein targeting to vacuole; and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to be located in late endosome membrane. Predicted to be part of ESCRT I complex. Orthologous to human VPS37C (VPS37C subunit of ESCRT-I). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
1q43
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (216760675..216787198)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (207336694..207362295)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (226742267..226774109)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene triokinase and FMN cyclase Neighboring gene damage-specific DNA binding protein 1 Neighboring gene von Willebrand factor C and EGF domains Neighboring gene pepsinogen A3 Neighboring gene uncharacterized LOC120099989 Neighboring gene Cd5 molecule Neighboring gene transfer RNA alanine (anticodon AGC) 22

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. VPS37 isoforms differentially modulate the ternary complex formation of ALIX, ALG-2, and ESCRT-I. Okumura M, et al. Biosci Biotechnol Biochem, 2013. PMID 23924735
  2. The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain. Agromayor M, et al. Structure, 2012 Mar 7. PMID 22405001, Free PMC Article
  3. Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding. Morita E, et al. Cell Host Microbe, 2007 Jul 12. PMID 18005716, Free PMC Article
  4. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
  5. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC189426

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to vacuole IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of ESCRT I complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ESCRT I complex ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
vacuolar protein sorting-associated protein 37C
Names
VPS37C, ESCRT-I subunit
vacuolar protein sorting 37 homolog C
vacuolar protein sorting 37C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001396992.2 → NP_001383921.1  vacuolar protein sorting-associated protein 37C isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    B5DFF4, M0R461
    Conserved Domains (2) summary
    PHA03247
    Location:194 → 351
    PHA03247; large tegument protein UL36; Provisional
    pfam07200
    Location:5 → 149
    Mod_r; Modifier of rudimentary (Mod(r)) protein

  2. NM_001396993.2 → NP_001383922.1  vacuolar protein sorting-associated protein 37C isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    B5DFF4, M0R461
    Conserved Domains (2) summary
    PHA03247
    Location:194 → 351
    PHA03247; large tegument protein UL36; Provisional
    pfam07200
    Location:5 → 149
    Mod_r; Modifier of rudimentary (Mod(r)) protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    216760675..216787198
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104948.2 → XP_038960876.1  vacuolar protein sorting-associated protein 37C isoform X1

    UniProtKB/TrEMBL
    B5DFF4, M0R461
    Conserved Domains (2) summary
    PHA03247
    Location:194 → 351
    PHA03247; large tegument protein UL36; Provisional
    pfam07200
    Location:5 → 149
    Mod_r; Modifier of rudimentary (Mod(r)) protein

  2. XM_063287864.1 → XP_063143934.1  vacuolar protein sorting-associated protein 37C isoform X2

  3. XM_063287808.1 → XP_063143878.1  vacuolar protein sorting-associated protein 37C isoform X2

  4. XM_063287835.1 → XP_063143905.1  vacuolar protein sorting-associated protein 37C isoform X2

  5. XM_063287728.1 → XP_063143798.1  vacuolar protein sorting-associated protein 37C isoform X1

    UniProtKB/TrEMBL
    B5DFF4, M0R461
    Related
    ENSRNOP00000064140.1, ENSRNOT00000074079.4

  6. XM_063287683.1 → XP_063143753.1  vacuolar protein sorting-associated protein 37C isoform X1

    UniProtKB/TrEMBL
    B5DFF4, M0R461

  7. XM_039104992.2 → XP_038960920.1  vacuolar protein sorting-associated protein 37C isoform X2

    Conserved Domains (1) summary
    pfam07200
    Location:5 → 149
    Mod_r; Modifier of rudimentary (Mod(r)) protein
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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