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VPS37C VPS37C subunit of ESCRT-I [ Homo sapiens (human) ]

Gene ID: 55048, updated on 8-Aug-2021

Summary

Official Symbol
VPS37Cprovided by HGNC
Official Full Name
VPS37C subunit of ESCRT-Iprovided by HGNC
Primary source
HGNC:HGNC:26097
See related
Ensembl:ENSG00000167987 MIM:610038
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
VPS37C is a subunit of ESCRT-I (endosomal sorting complex required for transport I), a complex in the class E vacuolar protein sorting (VPS) pathway required for sorting ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies (Eastman et al., 2005 [PubMed 15509564]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in prostate (RPKM 9.4), placenta (RPKM 8.1) and 25 other tissues See more
Orthologs
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Genomic context

See VPS37C in Genome Data Viewer
Location:
11q12.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (61130257..61161426, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (60897729..60928898, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene CD5 molecule Neighboring gene Sharpr-MPRA regulatory region 3147/8872 Neighboring gene pepsinogen A3 Neighboring gene pepsinogen A4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20847

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of ESCRT I complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of ESCRT I complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of ESCRT I complex TAS
Traceable Author Statement
more info
PubMed 
located_in endosome membrane TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
vacuolar protein sorting-associated protein 37C
Names
ESCRT-I complex subunit VPS37C
VPS37C, ESCRT-I subunit
hVps37C
vacuolar protein sorting 37 homolog C
vacuolar protein sorting 37C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017966.5NP_060436.4  vacuolar protein sorting-associated protein 37C

    See identical proteins and their annotated locations for NP_060436.4

    Status: VALIDATED

    Source sequence(s)
    AL834261, BM450171
    Consensus CDS
    CCDS31573.1
    UniProtKB/Swiss-Prot
    A5D8V6
    Related
    ENSP00000301765.5, ENST00000301765.10
    Conserved Domains (1) summary
    pfam07200
    Location:5146
    Mod_r; Modifier of rudimentary (Mod(r)) protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    61130257..61161426 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005274077.3XP_005274134.1  vacuolar protein sorting-associated protein 37C isoform X1

    See identical proteins and their annotated locations for XP_005274134.1

    UniProtKB/Swiss-Prot
    A5D8V6
    Conserved Domains (1) summary
    pfam07200
    Location:5146
    Mod_r; Modifier of rudimentary (Mod(r)) protein
  2. XM_017017955.1XP_016873444.1  vacuolar protein sorting-associated protein 37C isoform X2

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