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VPS37C VPS37C, ESCRT-I subunit [ Homo sapiens (human) ]

Gene ID: 55048, updated on 3-Jun-2018
Official Symbol
VPS37Cprovided by HGNC
Official Full Name
VPS37C, ESCRT-I subunitprovided by HGNC
Primary source
HGNC:HGNC:26097
See related
Ensembl:ENSG00000167987 MIM:610038; Vega:OTTHUMG00000167826
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
VPS37C is a subunit of ESCRT-I (endosomal sorting complex required for transport I), a complex in the class E vacuolar protein sorting (VPS) pathway required for sorting ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies (Eastman et al., 2005 [PubMed 15509564]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in prostate (RPKM 9.4), placenta (RPKM 8.1) and 25 other tissues See more
Orthologs
See VPS37C in Genome Data Viewer
Location:
11q12.2
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (61130256..61161444, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (60897728..60928916, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene CD5 molecule Neighboring gene Sharpr-MPRA regulatory region 3147/8872 Neighboring gene pepsinogen 3, group I (pepsinogen A) Neighboring gene pepsinogen 4, group I (pepsinogen A)

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
NHGRI GWA Catalog
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    Budding and maturation of HIV virion, organism-specific biosystemWith the virus components precariously assembled on the inner leaflet of the plasma membrane, the host cell machinery is required for viral budding. The virus takes advantage of the host ESCRT pathwa...
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  • ESCRT-I complex, organism-specific biosystem (from KEGG)
    ESCRT-I complex, organism-specific biosystemStructural complex; Genetic information processing; Protein processing
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  • Endosomal Sorting Complex Required For Transport (ESCRT), organism-specific biosystem (from REACTOME)
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  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ20847

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
endosomal transport TAS
Traceable Author Statement
more info
 
endosome transport via multivesicular body sorting pathway IEA
Inferred from Electronic Annotation
more info
 
macroautophagy TAS
Traceable Author Statement
more info
PubMed 
multivesicular body assembly TAS
Traceable Author Statement
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
viral budding via host ESCRT complex TAS
Traceable Author Statement
more info
PubMed 
viral life cycle TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
ESCRT I complex IDA
Inferred from Direct Assay
more info
PubMed 
ESCRT I complex TAS
Traceable Author Statement
more info
PubMed 
endosome membrane TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
late endosome membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
vacuolar protein sorting-associated protein 37C
Names
ESCRT-I complex subunit VPS37C
hVps37C
vacuolar protein sorting 37 homolog C
vacuolar protein sorting 37C

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017966.4NP_060436.4  vacuolar protein sorting-associated protein 37C

    See identical proteins and their annotated locations for NP_060436.4

    Status: VALIDATED

    Source sequence(s)
    AL834261, BM450171
    Consensus CDS
    CCDS31573.1
    UniProtKB/Swiss-Prot
    A5D8V6
    Related
    ENSP00000301765.5, OTTHUMP00000236974, ENST00000301765.9, OTTHUMT00000396467
    Conserved Domains (1) summary
    pfam07200
    Location:5146
    Mod_r; Modifier of rudimentary (Mod(r)) protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    61130256..61161444 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005274077.3XP_005274134.1  vacuolar protein sorting-associated protein 37C isoform X1

    See identical proteins and their annotated locations for XP_005274134.1

    UniProtKB/Swiss-Prot
    A5D8V6
    Conserved Domains (1) summary
    pfam07200
    Location:5146
    Mod_r; Modifier of rudimentary (Mod(r)) protein
  2. XM_017017955.1XP_016873444.1  vacuolar protein sorting-associated protein 37C isoform X2

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