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PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [ Cebus imitator (Panamanian white-faced capuchin) ]

Gene ID: 108287732, updated on 14-Mar-2024

Summary

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Gene symbol
PIK3CA
Gene description
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
See related
Ensembl:ENSCCAG00000028165
Gene type
protein coding
RefSeq status
MODEL
Organism
Cebus imitator
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae; Cebinae; Cebus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
23
Annotation release Status Assembly Chr Location
101 current Cebus_imitator-1.0 (GCF_001604975.1) Unplaced Scaffold NW_016107668.1 (763873..859276)

NW_016107668.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L6-like Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene U4 spliceosomal RNA Neighboring gene potassium calcium-activated channel subfamily M regulatory beta subunit 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_016107668 Unplaced Scaffold Reference Cebus_imitator-1.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of phosphatidylinositol 3-kinase complex, class IA IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of phosphatidylinositol 3-kinase complex, class IB IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Cebus imitator Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Cebus_imitator-1.0

Genomic

  1. NW_016107668.1 Reference Cebus_imitator-1.0

    Range
    763873..859276
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017506291.2 → XP_017361780.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

    UniProtKB/TrEMBL
    A0A2K5QXM4
    Conserved Domains (5) summary
    cd08398
    Location:325 → 484
    C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)
    smart00143
    Location:31 → 108
    PI3K_p85B; PI3-kinase family, p85-binding domain
    smart00144
    Location:173 → 292
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00872
    Location:525 → 696
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd05175
    Location:695 → 1064
    PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha

  2. XM_017506295.2 → XP_017361784.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

    UniProtKB/TrEMBL
    A0A2K5QXM4
    Conserved Domains (5) summary
    cd08398
    Location:325 → 484
    C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)
    smart00143
    Location:31 → 108
    PI3K_p85B; PI3-kinase family, p85-binding domain
    smart00144
    Location:173 → 292
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00872
    Location:525 → 696
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd05175
    Location:695 → 1064
    PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha

  3. XM_017506293.1 → XP_017361782.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

    UniProtKB/TrEMBL
    A0A2K5QXM4
    Conserved Domains (5) summary
    cd08398
    Location:325 → 484
    C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)
    smart00143
    Location:31 → 108
    PI3K_p85B; PI3-kinase family, p85-binding domain
    smart00144
    Location:173 → 292
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00872
    Location:525 → 696
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd05175
    Location:695 → 1064
    PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha

  4. XM_017506294.2 → XP_017361783.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

    UniProtKB/TrEMBL
    A0A2K5QXM4
    Related
    ENSCCAP00000020641.1, ENSCCAT00000038130.1
    Conserved Domains (5) summary
    cd08398
    Location:325 → 484
    C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)
    smart00143
    Location:31 → 108
    PI3K_p85B; PI3-kinase family, p85-binding domain
    smart00144
    Location:173 → 292
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00872
    Location:525 → 696
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd05175
    Location:695 → 1064
    PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha
Nucleotide Protein
Heading Accession and Version

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