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Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [ Mus musculus (house mouse) ]

Gene ID: 18706, updated on 27-Feb-2024

Summary

Official Symbol
Pik3caprovided by MGI
Official Full Name
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alphaprovided by MGI
Primary source
MGI:MGI:1206581
See related
Ensembl:ENSMUSG00000027665 AllianceGenome:MGI:1206581
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p110; caPI3K; p110alpha; 6330412C24Rik
Summary
Enables 1-phosphatidylinositol-3-kinase activity; insulin receptor substrate binding activity; and protein kinase activator activity. Involved in several processes, including phosphatidylinositol 3-kinase signaling; positive regulation of peptidyl-serine phosphorylation; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within several processes, including energy homeostasis; negative regulation of apoptotic process; and protein kinase B signaling. Located in intercalated disc and lamellipodium. Part of phosphatidylinositol 3-kinase complex. Is expressed in several structures, including early embryo; eye; and nervous system. Used to study CLOVES syndrome and breast cancer. Human ortholog(s) of this gene implicated in several diseases, including CLOVES syndrome; Cowden syndrome 5; breast cancer (multiple); cutaneous Paget's disease; and gastrointestinal system cancer (multiple). Orthologous to human PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 6.2), cerebellum adult (RPKM 5.7) and 26 other tissues See more
Orthologs
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Genomic context

See Pik3ca in Genome Data Viewer
Location:
3 A3; 3 15.7 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (32451203..32520256)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (32397065..32466112)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930429B21 gene Neighboring gene zinc finger matrin type 3 Neighboring gene STARR-seq mESC enhancer starr_07335 Neighboring gene STARR-seq mESC enhancer starr_07336 Neighboring gene STARR-positive B cell enhancer ABC_E7906 Neighboring gene predicted gene, 54172 Neighboring gene potassium large conductance calcium-activated channel, subfamily M, beta member 3 Neighboring gene STARR-positive B cell enhancer ABC_E6047 Neighboring gene STARR-seq mESC enhancer starr_07337 Neighboring gene STARR-positive B cell enhancer ABC_E6048 Neighboring gene STARR-seq mESC enhancer starr_07340 Neighboring gene STARR-positive B cell enhancer ABC_E2662 Neighboring gene zinc finger protein 639 Neighboring gene mitofusin 1 Neighboring gene STARR-seq mESC enhancer starr_07342 Neighboring gene guanine nucleotide binding protein (G protein), beta 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (18)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC161268

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 1-phosphatidylinositol-3-kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 1-phosphatidylinositol-3-kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables 1-phosphatidylinositol-3-kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS
Traceable Author Statement
more info
 
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables insulin receptor substrate binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within TORC2 signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within adipose tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_negative_effect autosome genomic imprinting IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cardiac muscle cell contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to hydrostatic pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within energy homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in insulin-like growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in insulin-like growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within liver development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of actin filament depolymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of anoikis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of fibroblast apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phagocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylinositol phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylinositol-3-phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of protein localization to membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of actin filament organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cellular respiration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in relaxation of cardiac muscle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to muscle stretch IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vascular endothelial growth factor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in intercalated disc IDA
Inferred from Direct Assay
more info
PubMed 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
part_of phosphatidylinositol 3-kinase complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of phosphatidylinositol 3-kinase complex ISO
Inferred from Sequence Orthology
more info
 
part_of phosphatidylinositol 3-kinase complex, class IA IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of phosphatidylinositol 3-kinase complex, class IA ISO
Inferred from Sequence Orthology
more info
 
part_of phosphatidylinositol 3-kinase complex, class IB IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Names
PI3-kinase subunit alpha
PI3K-alpha
PI3Kalpha
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha
phosphoinositide-3-kinase catalytic alpha polypeptide
ptdIns-3-kinase subunit alpha
ptdIns-3-kinase subunit p110-alpha
serine/threonine protein kinase PIK3CA
NP_032865.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008839.3NP_032865.2  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

    See identical proteins and their annotated locations for NP_032865.2

    Status: VALIDATED

    Source sequence(s)
    AC110034, AC130281
    Consensus CDS
    CCDS38409.1
    UniProtKB/Swiss-Prot
    P42337, Q0VGQ5
    Related
    ENSMUSP00000103878.2, ENSMUST00000108243.8
    Conserved Domains (5) summary
    cd08398
    Location:325484
    C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)
    cd00872
    Location:525696
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd05175
    Location:6951064
    PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha
    pfam00794
    Location:173292
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    32451203..32520256
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004941295.1 RNA Sequence