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NEU3 neuraminidase 3 [ Homo sapiens (human) ]

Gene ID: 10825, updated on 4-Jun-2020

Summary

Official Symbol
NEU3provided by HGNC
Official Full Name
neuraminidase 3provided by HGNC
Primary source
HGNC:HGNC:7760
See related
Ensembl:ENSG00000162139 MIM:604617
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIAL3
Summary
This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 5.8), prostate (RPKM 5.1) and 25 other tissues See more
Orthologs

Genomic context

See NEU3 in Genome Data Viewer
Location:
11q13.4
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (74988644..75010907)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (74699950..74718743)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene X-ray radiation resistance associated 1 Neighboring gene uncharacterized LOC107984352 Neighboring gene signal peptidase complex subunit 2 Neighboring gene RNA, U6 small nuclear 216, pseudogene Neighboring gene olfactory receptor family 2 subfamily AT member 2 pseudogene Neighboring gene nucleophosmin 1 pseudogene 50

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Removal of sialic acids from HIV-1 gp120 with neuraminidase (NA) enhances mannose-binding lectin (MBL) binding PubMed
env The desialylation of HIV-1 gp120 with neuraminidase greatly augments the initial virus-cell interaction, leading to remarkably enhanced viral replication and cytopathogenicity PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12388

Gene Ontology Provided by GOA

Function Evidence Code Pubs
alpha-sialidase activity IDA
Inferred from Direct Assay
more info
PubMed 
exo-alpha-(2->3)-sialidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
exo-alpha-(2->6)-sialidase activity IEA
Inferred from Electronic Annotation
more info
 
exo-alpha-(2->8)-sialidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
exo-alpha-sialidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
exo-alpha-sialidase activity IDA
Inferred from Direct Assay
more info
PubMed 
exo-alpha-sialidase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
carbohydrate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
ganglioside catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ganglioside catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
glycosphingolipid metabolic process TAS
Traceable Author Statement
more info
 
oligosaccharide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oligosaccharide catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sialidase-3
Names
N-acetyl-alpha-neuraminidase 3
ganglioside sialidase
membrane sialidase
sialidase 3 (membrane sialidase)
NP_001354789.1
NP_001354790.1
NP_001354791.1
NP_001354792.1
NP_001354793.1
NP_001354794.1
NP_001354795.1
NP_001354796.1
NP_006647.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001367860.1NP_001354789.1  sialidase-3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), as well as variant 1, encodes the longest isoform (a).
    Source sequence(s)
    AP001992, BC136397
    Related
    ENSP00000432097.1, ENST00000531509.5
  2. NM_001367861.1NP_001354790.1  sialidase-3 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variant 4, encodes isoform b.
    Source sequence(s)
    AP001992
  3. NM_001367862.1NP_001354791.1  sialidase-3 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variant 3, encodes isoform b.
    Source sequence(s)
    AP001992, DB099096
    Related
    ENSP00000434754.1, ENST00000534628.1
  4. NM_001367863.1NP_001354792.1  sialidase-3 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variant 6, encodes isoform c.
    Source sequence(s)
    AP001992
    Related
    ENSP00000434474.1, ENST00000529024.1
  5. NM_001367864.1NP_001354793.1  sialidase-3 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variant 5, encodes isoform c.
    Source sequence(s)
    AK303540, AP001992
    Related
    ENSP00000434907.1, ENST00000532963.1
  6. NM_001367865.1NP_001354794.1  sialidase-3 isoform d

    Status: REVIEWED

    Source sequence(s)
    AP001992
  7. NM_001367866.1NP_001354795.1  sialidase-3 isoform e

    Status: REVIEWED

    Source sequence(s)
    AP001992, BP352846
    Related
    ENSP00000436118.1, ENST00000531619.1
  8. NM_001367867.2NP_001354796.1  sialidase-3 isoform f

    Status: REVIEWED

    Source sequence(s)
    AP001992, BX108543
    Related
    ENSP00000436540.1, ENST00000526068.1
  9. NM_006656.6NP_006647.3  sialidase-3 isoform a

    See identical proteins and their annotated locations for NP_006647.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AP001992, CN429425, DB240271
    Consensus CDS
    CCDS44682.1
    UniProtKB/Swiss-Prot
    Q9UQ49
    UniProtKB/TrEMBL
    A0A024R5N6
    Related
    ENSP00000294064.4, ENST00000294064.9
    Conserved Domains (2) summary
    cd15482
    Location:44436
    Sialidase_non-viral; Non-viral sialidases
    pfam13088
    Location:70417
    BNR_2; BNR repeat-like domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    74988644..75010907
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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