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Neu3 neuraminidase 3 [ Mus musculus (house mouse) ]

Gene ID: 50877, updated on 8-May-2024

Summary

Official Symbol
Neu3provided by MGI
Official Full Name
neuraminidase 3provided by MGI
Primary source
MGI:MGI:1355305
See related
Ensembl:ENSMUSG00000035239 AllianceGenome:MGI:1355305
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables exo-alpha-(2->3)-sialidase activity. Involved in ganglioside catabolic process. Located in early endosome membrane; external side of plasma membrane; and recycling endosome membrane. Is expressed in brain. Orthologous to human NEU3 (neuraminidase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 13.1), ovary adult (RPKM 8.7) and 19 other tissues See more
Orthologs
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Genomic context

See Neu3 in Genome Data Viewer
Location:
7 E1; 7 54.15 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (99460646..99477579, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (99811434..99828457, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene UTP18, small subunit (SSU) processome component, homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_19661 Neighboring gene olfactory receptor family 2 subfamily AT member 1 Neighboring gene olfactory receptor enhancer Ikaria Neighboring gene STARR-positive B cell enhancer ABC_E3735 Neighboring gene STARR-seq mESC enhancer starr_19662 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:106976805-106976914 Neighboring gene STARR-positive B cell enhancer ABC_E3736 Neighboring gene signal peptidase complex subunit 2 homolog (S. cerevisiae) Neighboring gene STARR-positive B cell enhancer ABC_E1347 Neighboring gene X-ray radiation resistance associated 1 Neighboring gene predicted gene, 38405

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-sialidase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables exo-alpha-(2->3)-sialidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables exo-alpha-(2->3)-sialidase activity ISO
Inferred from Sequence Orthology
more info
 
enables exo-alpha-(2->6)-sialidase activity IEA
Inferred from Electronic Annotation
more info
 
enables exo-alpha-(2->8)-sialidase activity ISO
Inferred from Sequence Orthology
more info
 
enables exo-alpha-sialidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables exo-alpha-sialidase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in early endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in recycling endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in recycling endosome membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
sialidase-3
Names
N-acetyl-alpha-neuraminidase 3
Sialidase 3 (Membrane sialidase) (Ganglioside sialidase) (N-acetyl-alpha-neuraminidase 3)
ganglioside sialidase
membrane sialidase
NP_001405392.1
NP_057929.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418463.1NP_001405392.1  sialidase-3

    Status: VALIDATED

    Source sequence(s)
    AC115040
    UniProtKB/Swiss-Prot
    Q9JMH7
    UniProtKB/TrEMBL
    Q543I9
  2. NM_016720.3NP_057929.1  sialidase-3

    See identical proteins and their annotated locations for NP_057929.1

    Status: VALIDATED

    Source sequence(s)
    AC115040
    Consensus CDS
    CCDS21489.1
    UniProtKB/Swiss-Prot
    Q9JMH7
    UniProtKB/TrEMBL
    Q543I9
    Related
    ENSMUSP00000045222.7, ENSMUST00000036331.7
    Conserved Domains (1) summary
    cd15482
    Location:11402
    Sialidase_non-viral; Non-viral sialidases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    99460646..99477579 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)