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HSPH1 heat shock protein family H (Hsp110) member 1 [ Homo sapiens (human) ]

Gene ID: 10808, updated on 9-Feb-2020

Summary

Official Symbol
HSPH1provided by HGNC
Official Full Name
heat shock protein family H (Hsp110) member 1provided by HGNC
Primary source
HGNC:HGNC:16969
See related
Ensembl:ENSG00000120694 MIM:610703
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSP105; HSP105A; HSP105B; NY-CO-25
Summary
This gene encodes a member of the heat shock protein 70 family of proteins. The encoded protein functions as a nucleotide exchange factor for the molecular chaperone heat shock cognate 71 kDa protein (Hsc70). In addition, this protein plays a distinct but related role as a holdase that inhibits the aggregation of misfolded proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elevated expression of this protein has been observed in numerous human cancers. [provided by RefSeq, Mar 2017]
Expression
Broad expression in brain (RPKM 32.5), testis (RPKM 30.3) and 25 other tissues See more
Orthologs

Genomic context

See HSPH1 in Genome Data Viewer
Location:
13q12.3
Exon count:
20
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (31134973..31162388, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (31710762..31737246, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723392 Neighboring gene WD repeat domain 95, pseudogene Neighboring gene uncharacterized LOC105370148 Neighboring gene beta 3-glucosyltransferase Neighboring gene ankyrin repeat domain 26 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 is identified to have a physical interaction with heat shock 105kDa/110kDa protein 1 (HSPH1; HSP105) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 is identified to have a physical interaction with heat shock 105kDa/110kDa protein 1 (HSPH1; HSP105) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0201, DKFZp686M05240

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
adenyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
alpha-tubulin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
chaperone cofactor-dependent protein refolding IEA
Inferred from Electronic Annotation
more info
 
positive regulation of MHC class I biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
positive regulation of NK T cell activation TAS
Traceable Author Statement
more info
PubMed 
receptor-mediated endocytosis TAS
Traceable Author Statement
more info
 
regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
regulation of cellular response to heat TAS
Traceable Author Statement
more info
 
response to unfolded protein TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endocytic vesicle lumen TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
PubMed 
microtubule IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
heat shock protein 105 kDa
Names
antigen NY-CO-25
heat shock 105kDa/110kDa protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053051.1 RefSeqGene

    Range
    6206..33137
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001286503.1NP_001273432.1  heat shock protein 105 kDa isoform 2

    See identical proteins and their annotated locations for NP_001273432.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2, also known as Hsp105beta) is shorter than isoform 1.
    Source sequence(s)
    AB003333, AL137142, BC037553, DB077644
    Consensus CDS
    CCDS66525.1
    UniProtKB/Swiss-Prot
    Q92598
    UniProtKB/TrEMBL
    A0A024RDQ0
    Related
    ENSP00000369768.4, ENST00000380405.7
    Conserved Domains (1) summary
    cd11739
    Location:2384
    HSPH1_NBD; Nucleotide-binding domain of HSPH1
  2. NM_001286504.1NP_001273433.1  heat shock protein 105 kDa isoform 3

    See identical proteins and their annotated locations for NP_001273433.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AK302430, AL137142, BC037553, DB069199
    Consensus CDS
    CCDS66526.1
    UniProtKB/Swiss-Prot
    Q92598
    Related
    ENSP00000487365.1, ENST00000630972.2
    Conserved Domains (1) summary
    cl17037
    Location:39386
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  3. NM_001286505.1NP_001273434.1  heat shock protein 105 kDa isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and contains multiple differences in the coding region, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK302294, AK302430, AL137142, BC037553, DB069199
    Consensus CDS
    CCDS73559.1
    UniProtKB/Swiss-Prot
    Q92598
    UniProtKB/TrEMBL
    A0A0A0MSM0, B4DY72
    Related
    ENSP00000396090.3, ENST00000445273.6
    Conserved Domains (2) summary
    cl17037
    Location:39308
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    cl26953
    Location:39632
    HSP70; Hsp70 protein
  4. NM_001349704.2NP_001336633.1  heat shock protein 105 kDa isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) includes an alternate intron in its 3' coding region and differs in the 3' UTR compared to variant 1. The encoded isoform (5) has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL137142
    Conserved Domains (1) summary
    cd11739
    Location:2384
    HSPH1_NBD; Nucleotide-binding domain of HSPH1
  5. NM_006644.4NP_006635.2  heat shock protein 105 kDa isoform 1

    See identical proteins and their annotated locations for NP_006635.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1, also known as Hsp105alpha.
    Source sequence(s)
    AL137142, BC037553, CD251908
    Consensus CDS
    CCDS9340.1
    UniProtKB/Swiss-Prot
    Q92598
    UniProtKB/TrEMBL
    A0A024RDS1
    Related
    ENSP00000318687.5, ENST00000320027.10
    Conserved Domains (1) summary
    cd11739
    Location:2384
    HSPH1_NBD; Nucleotide-binding domain of HSPH1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    31134973..31162388 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020362.2XP_016875851.1  heat shock protein 105 kDa isoform X3

  2. XM_011534887.3XP_011533189.1  heat shock protein 105 kDa isoform X1

    Conserved Domains (2) summary
    pfam00012
    Location:39710
    HSP70; Hsp70 protein
    cl17037
    Location:39386
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  3. XM_005266236.2XP_005266293.1  heat shock protein 105 kDa isoform X2

    See identical proteins and their annotated locations for XP_005266293.1

    Conserved Domains (2) summary
    pfam00012
    Location:39666
    HSP70; Hsp70 protein
    cl17037
    Location:39386
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  4. XM_017020364.2XP_016875853.1  heat shock protein 105 kDa isoform X6

  5. XM_011534888.2XP_011533190.1  heat shock protein 105 kDa isoform X5

    Conserved Domains (2) summary
    pfam00012
    Location:3630
    HSP70; Hsp70 protein
    cl17037
    Location:2306
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  6. XM_017020363.2XP_016875852.1  heat shock protein 105 kDa isoform X4

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