Hsph1 heat shock 105kDa/110kDa protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hsph1provided by MGI
Official Full Name: heat shock 105kDa/110kDa protein 1provided by MGI
Primary source: MGI:MGI:105053
See related: Ensembl:ENSMUSG00000029657 AllianceGenome:MGI:105053
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 105kDa; Hsp105; Hsp110; hsp-E7I; hsp110/105
Summary: Enables alpha-tubulin binding activity. Acts upstream of or within several processes, including chaperone cofactor-dependent protein refolding; negative regulation of intracellular signal transduction; and positive regulation of nitrogen compound metabolic process. Located in cytoplasm and nucleus. Colocalizes with microtubule. Is expressed in several structures, including brain; gut; integumental system; liver and biliary system; and reproductive system. Orthologous to human HSPH1 (heat shock protein family H (Hsp110) member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in cortex adult (RPKM 30.2), CNS E11.5 (RPKM 29.9) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G3; 5 89.18 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (149540308..149562594, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (149616843..149636498, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of HSP110 attenuates hypoxia-induced pulmonary hypertension in mice through suppression of YAP/TAZ-TEAD4 pathway.
Title: Knockdown of HSP110 attenuates hypoxia-induced pulmonary hypertension in mice through suppression of YAP/TAZ-TEAD4 pathway.
Hsp105alpha suppresses Adriamycin-induced cell death via nuclear localization signal-dependent nuclear accumulation.
Title: Hsp105α suppresses Adriamycin-induced cell death via nuclear localization signal-dependent nuclear accumulation.
These observations suggest that GGA administration is a therapeutic candidate for depressive diseases by increasing hippocampal BDNF levels via HSP105 expression.
Title: HSP105 prevents depression-like behavior by increasing hippocampal brain-derived neurotrophic factor levels in mice.
Hsp105 may play an important role in the refolding of denatured proteins and protection against stress-induced cell death in mammalian cells.
Title: Characterization of stress sensitivity and chaperone activity of Hsp105 in mammalian cells.
hsp110/105 KO mice are resistant to ischemic injury and that the protective effects of hsp110/105 deficiency in cerebral ischemia may partly be mediated by an increase in the chaperone activity of Hsp70.
Title: Targeted disruption of Hsp110/105 gene protects against ischemic stress.
HSP105 appears to chaperone the responses to endoplasmic reticulum (ER) stress through its interactions with GRP78 and GSK3, and without HSP105 cell death following ER stress proceeds by a non-caspase-3-dependent process.
Title: HSP105 interacts with GRP78 and GSK3 and promotes ER stress-induced caspase-3 activation.
Data suggest that Hsp105 has opposite effects on stress-induced apoptosis depending on the cell type; a pro-apoptotic effect in embryonal cells and an anti-apoptotic effect in neuronal cells.
Title: Hsp105alpha enhances stress-induced apoptosis but not necrosis in mouse embryonal f9 cells.
The constitutive overexpression of HSP105 in cancer cells is involved in malignant transformation by protecting tumor cells from apoptosis.
Title: Synthetic small interfering RNA targeting heat shock protein 105 induces apoptosis of various cancer cells both in vitro and in vivo.
Hsp110 over-expression increases the immunogenicity of the murine CT26 colon tumor.
Title: Hsp110 over-expression increases the immunogenicity of the murine CT26 colon tumor.
enhances activation of p38, release of cytochrome c and caspase activation; may play important roles in organogenesis, during which marked apoptosis occurs, by enhancing apoptosis during mouse embryogenesis
Title: Enhancement of oxidative stress-induced apoptosis by Hsp105alpha in mouse embryonal F9 cells.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hsp105 (e-PCR), detects polymorphism
- UniSTS:143409

NoName (e-PCR)
- UniSTS:235373

AI790491 (e-PCR)
- UniSTS:179330

L40406 (e-PCR)
- UniSTS:124911

Homology

Homologs of the Hsph1 gene: The Hsph1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and S.cerevisiae.
Orthologs from Annotation Pipeline: 344 organisms have orthologs with human gene Hsph1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables adenyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables alpha-tubulin binding	IDA Inferred from Direct Assay more info	PubMed
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within chaperone cofactor-dependent protein refolding	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuron apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of MHC class I biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of NK T cell activation	TAS Traceable Author Statement more info	PubMed
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of microtubule cytoskeleton organization	NAS Non-traceable Author Statement more info	PubMed
involved_in response to unfolded protein	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular region	TAS Traceable Author Statement more info	PubMed
colocalizes_with microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: heat shock protein 105 kDa

Names: 42 degrees C-HSP; HSP105 42 C-HSP; heat shock 110 kDa protein; heat shock protein 110; heat shock-related 100 kDa protein E7I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347534.1 → NP_001334463.1 heat shock protein 105 kDa isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC119856

Consensus CDS

CCDS85010.1

UniProtKB/Swiss-Prot

Q61699

Related

ENSMUSP00000074392.9, ENSMUST00000074846.14
NM_013559.2 → NP_038587.2 heat shock protein 105 kDa isoform 1

See identical proteins and their annotated locations for NP_038587.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK146697, AK165046, AK172913, CF164049

Consensus CDS

CCDS19885.1

UniProtKB/Swiss-Prot

Q61699, Q8VCW6

Related

ENSMUSP00000144413.2, ENSMUST00000202361.4

Conserved Domains (3) summary

cd11739
Location:2 → 384

HSPH1_NBD; Nucleotide-binding domain of HSPH1

pfam00012
Location:3 → 709

HSP70; Hsp70 protein

pfam13552
Location:660 → 742

DUF4127; Protein of unknown function (DUF4127)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

149540308..149562594 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006504916.4 → XP_006504979.1 heat shock protein 105 kDa isoform X2

Conserved Domains (3) summary

COG3087
Location:537 → 620

FtsN; Cell division protein FtsN [Cell cycle control, cell division, chromosome partitioning]

pfam13552
Location:673 → 761

DUF4127; Protein of unknown function (DUF4127)

cl17037
Location:56 → 403

NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
XM_030254168.2 → XP_030110028.1 heat shock protein 105 kDa isoform X1

Conserved Domains (3) summary

COG3087
Location:425 → 508

FtsN; Cell division protein FtsN [Cell cycle control, cell division, chromosome partitioning]

pfam13552
Location:561 → 649

DUF4127; Protein of unknown function (DUF4127)

cl17037
Location:1 → 291

NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily