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Hsph1 heat shock 105kDa/110kDa protein 1 [ Mus musculus (house mouse) ]

Gene ID: 15505, updated on 1-Mar-2024

Summary

Official Symbol
Hsph1provided by MGI
Official Full Name
heat shock 105kDa/110kDa protein 1provided by MGI
Primary source
MGI:MGI:105053
See related
Ensembl:ENSMUSG00000029657 AllianceGenome:MGI:105053
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
105kDa; Hsp105; Hsp110; hsp-E7I; hsp110/105
Summary
Enables alpha-tubulin binding activity. Acts upstream of or within several processes, including chaperone cofactor-dependent protein refolding; negative regulation of intracellular signal transduction; and positive regulation of nitrogen compound metabolic process. Located in cytoplasm and nucleus. Colocalizes with microtubule. Is expressed in several structures, including brain; gut; integumental system; liver and biliary system; and reproductive system. Orthologous to human HSPH1 (heat shock protein family H (Hsp110) member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 30.2), CNS E11.5 (RPKM 29.9) and 25 other tissues See more
Orthologs
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Genomic context

See Hsph1 in Genome Data Viewer
Location:
5 G3; 5 89.18 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (149540308..149562594, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (149616843..149636498, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15997 Neighboring gene WD40 repeat domain 95 Neighboring gene predicted gene, 54316 Neighboring gene STARR-seq mESC enhancer starr_14938 Neighboring gene predicted gene, 35763 Neighboring gene STARR-positive B cell enhancer ABC_E3638 Neighboring gene STARR-positive B cell enhancer ABC_E1317 Neighboring gene STARR-seq mESC enhancer starr_14940 Neighboring gene predicted gene, 20005 Neighboring gene NME/NM23 nucleoside diphosphate kinase, pseudogene 1 Neighboring gene beta-3-glucosyltransferase Neighboring gene STARR-seq mESC enhancer starr_14941 Neighboring gene predicted gene, 36141

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
 
enables adenyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables adenyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
enables alpha-tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
PubMed 
colocalizes_with microtubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
heat shock protein 105 kDa
Names
42 degrees C-HSP
HSP105 42 C-HSP
heat shock 110 kDa protein
heat shock protein 110
heat shock-related 100 kDa protein E7I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347534.1NP_001334463.1  heat shock protein 105 kDa isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC119856
    Consensus CDS
    CCDS85010.1
    UniProtKB/TrEMBL
    E9Q0U7
    Related
    ENSMUSP00000074392.9, ENSMUST00000074846.14
  2. NM_013559.2NP_038587.2  heat shock protein 105 kDa isoform 1

    See identical proteins and their annotated locations for NP_038587.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK146697, AK165046, AK172913, CF164049
    Consensus CDS
    CCDS19885.1
    UniProtKB/Swiss-Prot
    Q3TNS2, Q3UIY8, Q61699, Q62578, Q62579, Q6A0A5, Q8C430, Q8VCW6
    UniProtKB/TrEMBL
    E9Q0U7
    Related
    ENSMUSP00000144413.2, ENSMUST00000202361.4
    Conserved Domains (3) summary
    cd11739
    Location:2384
    HSPH1_NBD; Nucleotide-binding domain of HSPH1
    pfam00012
    Location:3709
    HSP70; Hsp70 protein
    pfam13552
    Location:660742
    DUF4127; Protein of unknown function (DUF4127)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    149540308..149562594 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504916.4XP_006504979.1  heat shock protein 105 kDa isoform X2

    UniProtKB/TrEMBL
    E9Q0U7
    Conserved Domains (3) summary
    COG3087
    Location:537620
    FtsN; Cell division protein FtsN [Cell cycle control, cell division, chromosome partitioning]
    pfam13552
    Location:673761
    DUF4127; Protein of unknown function (DUF4127)
    cl17037
    Location:56403
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  2. XM_030254168.2XP_030110028.1  heat shock protein 105 kDa isoform X1

    UniProtKB/TrEMBL
    E9Q0U7
    Conserved Domains (3) summary
    COG3087
    Location:425508
    FtsN; Cell division protein FtsN [Cell cycle control, cell division, chromosome partitioning]
    pfam13552
    Location:561649
    DUF4127; Protein of unknown function (DUF4127)
    cl17037
    Location:1291
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily