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ZNF460 zinc finger protein 460 [ Homo sapiens (human) ]

Gene ID: 10794, updated on 3-May-2025
Official Symbol
ZNF460provided by HGNC
Official Full Name
zinc finger protein 460provided by HGNC
Primary source
HGNC:HGNC:21628
See related
Ensembl:ENSG00000197714 MIM:604755; AllianceGenome:HGNC:21628
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HZF8; ZNF272
Summary
Zinc finger proteins, such as ZNF272, interact with nucleic acids and have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See ZFP93 (MIM 604749) for additional information on zinc finger proteins.[supplied by OMIM, May 2004]
Expression
Ubiquitous expression in adrenal (RPKM 1.2), bone marrow (RPKM 1.1) and 25 other tissues See more
Orthologs
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See ZNF460 in Genome Data Viewer
Location:
19q13.43
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (57279982..57294069)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (60376424..60390576)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (57791350..57805437)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15127 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15128 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11073 Neighboring gene aurora kinase C Neighboring gene Sharpr-MPRA regulatory region 2652 Neighboring gene zinc finger protein 805 Neighboring gene NANOG hESC enhancer GRCh37_chr19:57774577-57775110 Neighboring gene ZNF460 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11074 Neighboring gene Sharpr-MPRA regulatory region 5355 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:57791112-57792311 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11075 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15130 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:57814007-57814506 Neighboring gene PPPDE peptidase domain containing 1 pseudogene Neighboring gene Sharpr-MPRA regulatory region 10022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:57830216-57830733 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15132 Neighboring gene zinc finger protein 543

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
zinc finger protein 460
Names
zinc finger protein 272
zinc finger protein HZF8

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330622.2NP_001317551.1  zinc finger protein 460 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC005261, AK298106, AW293116, DC415509
    Consensus CDS
    CCDS82404.1
    UniProtKB/Swiss-Prot
    Q14592
    Related
    ENSP00000446167.1, ENST00000537645.5
  2. NM_006635.4NP_006626.3  zinc finger protein 460 isoform 1

    See identical proteins and their annotated locations for NP_006626.3

    Status: VALIDATED

    Source sequence(s)
    AC005261, AK074582, BC118625, DA991801
    Consensus CDS
    CCDS12949.1
    UniProtKB/Swiss-Prot
    A4FU64, B4DNX9, Q14592, Q2VPC7, Q6VSF8
    Related
    ENSP00000353491.2, ENST00000360338.4
    Conserved Domains (3) summary
    COG5048
    Location:222552
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:198218
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1253
    KRAB; KRAB box

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    57279982..57294069
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438079.1XP_047294035.1  zinc finger protein 460 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    60376424..60390576
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319573.1XP_054175548.1  zinc finger protein 460 isoform X1