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NEK6 NIMA related kinase 6 [ Homo sapiens (human) ]

Gene ID: 10783, updated on 29-Mar-2023

Summary

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Official Symbol
NEK6provided by HGNC
Official Full Name
NIMA related kinase 6provided by HGNC
Primary source
HGNC:HGNC:7749
See related
Ensembl:ENSG00000119408 MIM:604884; AllianceGenome:HGNC:7749
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SID6-1512
Summary
The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in placenta (RPKM 13.1), appendix (RPKM 13.0) and 25 other tissues See more
Orthologs
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Genomic context

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See NEK6 in Genome Data Viewer
Location:
9q33.3
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (124257606..124353307)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (136455708..136551354)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (127019885..127115586)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127005315-127005831 Neighboring gene Sharpr-MPRA regulatory region 14990 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:127020845-127021790 Neighboring gene uncharacterized LOC124902268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127026232-127026845 Neighboring gene uncharacterized LOC613206 Neighboring gene Sharpr-MPRA regulatory region 10556 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:127048049-127049248 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127054700-127055684 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127058683-127059590 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127061405-127062310 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127070759-127071606 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:127071689-127072888 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127077520-127078020 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127104704-127105575 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127105576-127106448 Neighboring gene uncharacterized LOC100129034 Neighboring gene proteasome 20S subunit beta 7 Neighboring gene uncharacterized LOC124902267

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. NEK6 Regulates Redox Balance and DNA Damage Response in DU-145 Prostate Cancer Cells. Pavan ICB, et al. Cells, 2023 Jan 7. PMID 36672191, Free PMC Article
  2. Predictive Role of NEK6 in Prognosis and Immune Infiltration in Head and Neck Squamous Cell Carcinoma. Yang ZM, et al. Front Endocrinol (Lausanne), 2022. PMID 35898455, Free PMC Article
  3. Overexpression of NIMA-related kinase 6 (NEK6) contributes to malignant growth and dismal prognosis in Human Breast Cancer. He Z, et al. Pathol Res Pract, 2018 Oct. PMID 30153958
  4. cis-Regulatory Circuits Regulating NEK6 Kinase Overexpression in Transformed B Cells Are Super-Enhancer Independent. Huang Y, et al. Cell Rep, 2017 Mar 21. PMID 28329684, Free PMC Article
  5. The inhibition of Nek6 function sensitizes human cancer cells to premature senescence upon serum reduction or anticancer drug treatment. Jee HJ, et al. Cancer Lett, 2013 Jul 10. PMID 23416273

See all (70) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NEK6 Regulates Redox Balance and DNA Damage Response in DU-145 Prostate Cancer Cells.
    Title: NEK6 Regulates Redox Balance and DNA Damage Response in DU-145 Prostate Cancer Cells.
  2. Predictive Role of NEK6 in Prognosis and Immune Infiltration in Head and Neck Squamous Cell Carcinoma.
    Title: Predictive Role of NEK6 in Prognosis and Immune Infiltration in Head and Neck Squamous Cell Carcinoma.
  3. NEK6 is an injury-responsive kinase cooperating with STAT3 in regulation of reactive astrogliosis.
    Title: NEK6 is an injury-responsive kinase cooperating with STAT3 in regulation of reactive astrogliosis.
  4. Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression.
    Title: Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression.
  5. CircNEK6 promoted the progression of thyroid cancer through up-regulating FZD8 and activating Wnt signaling pathway by targeting miR-370-3p.
    Title: Emerging roles of circRNA_NEK6 targeting miR-370-3p in the proliferation and invasion of thyroid cancer via Wnt signaling pathway.
  6. our results imply that Nek6 plays a facilitating role in breast cancer cell proliferation
    Title: Overexpression of NIMA-related kinase 6 (NEK6) contributes to malignant growth and dismal prognosis in Human Breast Cancer.
  7. cis-regulatory circuits that lead to overexpression of NEK6, a mitosis-associated kinase, in human B cell lymphoma, were analyzed.
    Title: cis-Regulatory Circuits Regulating NEK6 Kinase Overexpression in Transformed B Cells Are Super-Enhancer Independent.
  8. High NEK6 expression is associated with Cluster Amplified Centrosomes in cancer.
    Title: Hsp72 and Nek6 Cooperate to Cluster Amplified Centrosomes in Cancer Cells.
  9. Signaling cascade of the NIMA-related kinases (Neks) Nek6, Nek7, and Nek9 is required for the localization and function of two kinesins essential for cytokinesis, Mklp2 and Kif14 to properly coordinate cytokinesis.
    Title: A bifurcated signaling cascade of NIMA-related kinases controls distinct kinesins in anaphase.
  10. our studies establish NEK6 signaling as a central mechanism mediating castration-resistant prostate cancer
    Title: Castration Resistance in Prostate Cancer Is Mediated by the Kinase NEK6.
Submit: New GeneRIF Correction See all GeneRIFs (36)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common genetic variation and performance on standardized cognitive tests.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables kinesin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
  
enables transcription corepressor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in chromosome segregation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic nuclear membrane disassembly TAS
Traceable Author Statement
more info
  
involved_in mitotic spindle organization TAS
Traceable Author Statement
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling HMP PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cellular senescence TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of mitotic cell cycle TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of mitotic metaphase/anaphase transition IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in regulation of mitotic metaphase/anaphase transition IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in spindle assembly TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in centriolar satellite IDA
Inferred from Direct Assay
more info
  
colocalizes_with centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase Nek6
Names
NIMA (never in mitosis gene a)-related kinase 6
never in mitosis A-related kinase 6
nimA-related protein kinase 6
protein kinase SID6-1512
putative serine-threonine protein kinase
NP_001138473.1
NP_001159639.1
NP_001159640.1
NP_001159641.1
NP_001159642.1
NP_001159643.1
NP_055212.2
XP_016869706.1
XP_024303155.1
XP_047278607.1
XP_047278608.1
XP_047278609.1
XP_047278610.1
XP_054217767.1
XP_054217768.1
XP_054217769.1
XP_054217770.1
XP_054217771.1
XP_054217772.1
XP_054217773.1
XP_054217774.1
XP_054217775.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145001.3 → NP_001138473.1  serine/threonine-protein kinase Nek6 isoform 1

    See identical proteins and their annotated locations for NP_001138473.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 7 encode the same isoform (1).
    Source sequence(s)
    AF087909, AL137846, BC004174, BC012761, CF994196
    Consensus CDS
    CCDS48015.1
    UniProtKB/Swiss-Prot
    Q9HC98
    Related
    ENSP00000362702.3, ENST00000373600.7
    Conserved Domains (2) summary
    smart00220
    Location:79 → 344
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08228
    Location:76 → 343
    STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6

  2. NM_001166167.2 → NP_001159639.1  serine/threonine-protein kinase Nek6 isoform 3

    See identical proteins and their annotated locations for NP_001159639.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AF087909, AL137846, BC012761, BM083872
    Consensus CDS
    CCDS55338.1
    UniProtKB/Swiss-Prot
    Q9HC98
    Related
    ENSP00000441469.1, ENST00000540326.5
    Conserved Domains (2) summary
    smart00220
    Location:63 → 328
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08228
    Location:60 → 327
    STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6

  3. NM_001166168.2 → NP_001159640.1  serine/threonine-protein kinase Nek6 isoform 2

    See identical proteins and their annotated locations for NP_001159640.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 5 and 6 encode the same isoform (2).
    Source sequence(s)
    AF087909, AL137846, AL162724, BC012761, BP279761
    Consensus CDS
    CCDS6854.1
    UniProtKB/Swiss-Prot
    Q9HC98, Q9ULX2
    UniProtKB/TrEMBL
    A0A024R8A6
    Related
    ENSP00000442636.1, ENST00000545174.5
    Conserved Domains (1) summary
    cd08228
    Location:42 → 309
    STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6

  4. NM_001166169.2 → NP_001159641.1  serine/threonine-protein kinase Nek6 isoform 4

    See identical proteins and their annotated locations for NP_001159641.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK294614, AL137846, AL162724, BC012761
    Consensus CDS
    CCDS55339.1
    UniProtKB/Swiss-Prot
    Q9HC98
    Related
    ENSP00000439651.1, ENST00000539416.5
    Conserved Domains (2) summary
    smart00220
    Location:70 → 335
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08228
    Location:67 → 334
    STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6

  5. NM_001166170.2 → NP_001159642.1  serine/threonine-protein kinase Nek6 isoform 2

    See identical proteins and their annotated locations for NP_001159642.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 5 and 6 encode the same isoform (2).
    Source sequence(s)
    AL137846, AL162724, BC012761
    Consensus CDS
    CCDS6854.1
    UniProtKB/Swiss-Prot
    Q9HC98, Q9ULX2
    UniProtKB/TrEMBL
    A0A024R8A6
    Related
    ENSP00000441426.1, ENST00000546191.5
    Conserved Domains (1) summary
    cd08228
    Location:42 → 309
    STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6

  6. NM_001166171.2 → NP_001159643.1  serine/threonine-protein kinase Nek6 isoform 1

    See identical proteins and their annotated locations for NP_001159643.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Both variants 1 and 7 encode the same protein.
    Source sequence(s)
    AL137846, AL162724, BC012761, DB350175
    Consensus CDS
    CCDS48015.1
    UniProtKB/Swiss-Prot
    Q9HC98
    Related
    ENSP00000377749.2, ENST00000394199.6
    Conserved Domains (2) summary
    smart00220
    Location:79 → 344
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08228
    Location:76 → 343
    STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6

  7. NM_014397.6 → NP_055212.2  serine/threonine-protein kinase Nek6 isoform 2

    See identical proteins and their annotated locations for NP_055212.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 5 and 6 encode the same isoform (2).
    Source sequence(s)
    AF087909, AL137846, BC012761, CF994196
    Consensus CDS
    CCDS6854.1
    UniProtKB/Swiss-Prot
    Q9HC98, Q9ULX2
    UniProtKB/TrEMBL
    A0A024R8A6
    Related
    ENSP00000319734.5, ENST00000320246.10
    Conserved Domains (1) summary
    cd08228
    Location:42 → 309
    STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    124257606..124353307
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422652.1 → XP_047278608.1  serine/threonine-protein kinase Nek6 isoform X2

  2. XM_024447387.2 → XP_024303155.1  serine/threonine-protein kinase Nek6 isoform X4

    UniProtKB/Swiss-Prot
    Q9ULX2
    UniProtKB/TrEMBL
    A0A024R8A6
    Conserved Domains (1) summary
    cd08228
    Location:42 → 309
    STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6

  3. XM_047422653.1 → XP_047278609.1  serine/threonine-protein kinase Nek6 isoform X3

  4. XM_017014217.2 → XP_016869706.1  serine/threonine-protein kinase Nek6 isoform X2

    UniProtKB/Swiss-Prot
    Q9HC98
    Conserved Domains (2) summary
    smart00220
    Location:79 → 344
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08228
    Location:76 → 343
    STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6

  5. XM_047422651.1 → XP_047278607.1  serine/threonine-protein kinase Nek6 isoform X1

  6. XM_047422654.1 → XP_047278610.1  serine/threonine-protein kinase Nek6 isoform X2

RNA

  1. XR_007061235.1 RNA Sequence

  2. XR_007061234.1 RNA Sequence

  3. XR_007061237.1 RNA Sequence

  4. XR_007061236.1 RNA Sequence

  5. XR_007061238.1 RNA Sequence

  6. XR_007061233.1 RNA Sequence

  7. XR_007061232.1 RNA Sequence

  8. XR_007061231.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    136455708..136551354
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361796.1 → XP_054217771.1  serine/threonine-protein kinase Nek6 isoform X4

  2. XM_054361797.1 → XP_054217772.1  serine/threonine-protein kinase Nek6 isoform X4

  3. XM_054361798.1 → XP_054217773.1  serine/threonine-protein kinase Nek6 isoform X4

  4. XM_054361794.1 → XP_054217769.1  serine/threonine-protein kinase Nek6 isoform X3

  5. XM_054361800.1 → XP_054217775.1  serine/threonine-protein kinase Nek6 isoform X4

  6. XM_054361793.1 → XP_054217768.1  serine/threonine-protein kinase Nek6 isoform X2

  7. XM_054361792.1 → XP_054217767.1  serine/threonine-protein kinase Nek6 isoform X1

  8. XM_054361799.1 → XP_054217774.1  serine/threonine-protein kinase Nek6 isoform X4

  9. XM_054361795.1 → XP_054217770.1  serine/threonine-protein kinase Nek6 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HC98.2 GenPept UniProtKB/Swiss-Prot:Q9HC98

Gene LinkOut

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