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NEK6 NIMA related kinase 6 [ Homo sapiens (human) ]

Gene ID: 10783, updated on 23-Nov-2023

Summary

Official Symbol
NEK6provided by HGNC
Official Full Name
NIMA related kinase 6provided by HGNC
Primary source
HGNC:HGNC:7749
See related
Ensembl:ENSG00000119408 MIM:604884; AllianceGenome:HGNC:7749
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SID6-1512
Summary
The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in placenta (RPKM 13.1), appendix (RPKM 13.0) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See NEK6 in Genome Data Viewer
Location:
9q33.3
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (124257606..124353307)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (136455708..136551354)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (127019885..127115586)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:126774959-126775531 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:126775532-126776104 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126792309-126793096 Neighboring gene uncharacterized LOC107987037 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126803186-126803720 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126803721-126804253 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:126807814-126808609 Neighboring gene LIM homeobox 2 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:126840763-126841962 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28957 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:126893859-126894071 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28958 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28959 Neighboring gene Sharpr-MPRA regulatory region 10969 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:126905749-126906322 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:126906323-126906898 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:126906899-126907472 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28960 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28961 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28962 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:126964420-126964620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28964 Neighboring gene NFE2L2 motif-containing MPRA enhancer 159 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20258 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20259 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28967 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28966 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28969 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28970 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127004798-127005314 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127005315-127005831 Neighboring gene Sharpr-MPRA regulatory region 14990 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28971 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28973 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28972 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20260 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20261 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:127020845-127021790 Neighboring gene uncharacterized LOC124902268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127026232-127026845 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20262 Neighboring gene uncharacterized LOC613206 Neighboring gene Sharpr-MPRA regulatory region 10556 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:127047786-127047960 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:127048049-127049248 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28977 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28978 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28979 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127054700-127055684 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28980 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28981 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127058683-127059590 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127061405-127062310 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127070759-127071606 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:127071689-127072888 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127077520-127078020 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28982 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28983 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28984 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127104704-127105575 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127105576-127106448 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_106555 Neighboring gene uncharacterized LOC100129034 Neighboring gene uncharacterized LOC124902267 Neighboring gene proteasome 20S subunit beta 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables kinesin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
enables transcription corepressor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chromosome segregation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitotic nuclear membrane disassembly TAS
Traceable Author Statement
more info
 
involved_in mitotic spindle organization TAS
Traceable Author Statement
more info
 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction HMP PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cellular senescence TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of mitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of mitotic metaphase/anaphase transition IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of mitotic metaphase/anaphase transition IDA
Inferred from Direct Assay
more info
PubMed 
involved_in spindle assembly TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in centriolar satellite IDA
Inferred from Direct Assay
more info
 
colocalizes_with centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase Nek6
Names
NIMA (never in mitosis gene a)-related kinase 6
never in mitosis A-related kinase 6
nimA-related protein kinase 6
protein kinase SID6-1512
putative serine-threonine protein kinase
NP_001138473.1
NP_001159639.1
NP_001159640.1
NP_001159641.1
NP_001159642.1
NP_001159643.1
NP_055212.2
XP_016869706.1
XP_024303155.1
XP_047278607.1
XP_047278608.1
XP_047278609.1
XP_047278610.1
XP_054217767.1
XP_054217768.1
XP_054217769.1
XP_054217770.1
XP_054217771.1
XP_054217772.1
XP_054217773.1
XP_054217774.1
XP_054217775.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145001.3NP_001138473.1  serine/threonine-protein kinase Nek6 isoform 1

    See identical proteins and their annotated locations for NP_001138473.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 7 encode the same isoform (1).
    Source sequence(s)
    AF087909, AL137846, BC004174, BC012761, CF994196
    Consensus CDS
    CCDS48015.1
    UniProtKB/Swiss-Prot
    Q9HC98
    Related
    ENSP00000362702.3, ENST00000373600.7
    Conserved Domains (2) summary
    smart00220
    Location:79344
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08228
    Location:76343
    STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6
  2. NM_001166167.2NP_001159639.1  serine/threonine-protein kinase Nek6 isoform 3

    See identical proteins and their annotated locations for NP_001159639.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AF087909, AL137846, BC012761, BM083872
    Consensus CDS
    CCDS55338.1
    UniProtKB/Swiss-Prot
    Q9HC98
    Related
    ENSP00000441469.1, ENST00000540326.5
    Conserved Domains (2) summary
    smart00220
    Location:63328
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08228
    Location:60327
    STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6
  3. NM_001166168.2NP_001159640.1  serine/threonine-protein kinase Nek6 isoform 2

    See identical proteins and their annotated locations for NP_001159640.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 5 and 6 encode the same isoform (2).
    Source sequence(s)
    AF087909, AL137846, AL162724, BC012761, BP279761
    Consensus CDS
    CCDS6854.1
    UniProtKB/Swiss-Prot
    B7Z2D9, Q5TBG3, Q5TBG9, Q6FG86, Q6IAR3, Q96E83, Q9HC98, Q9ULX2
    Related
    ENSP00000442636.1, ENST00000545174.5
    Conserved Domains (1) summary
    cd08228
    Location:42309
    STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6
  4. NM_001166169.2NP_001159641.1  serine/threonine-protein kinase Nek6 isoform 4

    See identical proteins and their annotated locations for NP_001159641.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK294614, AL137846, AL162724, BC012761
    Consensus CDS
    CCDS55339.1
    UniProtKB/Swiss-Prot
    Q9HC98
    Related
    ENSP00000439651.1, ENST00000539416.5
    Conserved Domains (2) summary
    smart00220
    Location:70335
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08228
    Location:67334
    STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6
  5. NM_001166170.2NP_001159642.1  serine/threonine-protein kinase Nek6 isoform 2

    See identical proteins and their annotated locations for NP_001159642.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 5 and 6 encode the same isoform (2).
    Source sequence(s)
    AL137846, AL162724, BC012761
    Consensus CDS
    CCDS6854.1
    UniProtKB/Swiss-Prot
    B7Z2D9, Q5TBG3, Q5TBG9, Q6FG86, Q6IAR3, Q96E83, Q9HC98, Q9ULX2
    Related
    ENSP00000441426.1, ENST00000546191.5
    Conserved Domains (1) summary
    cd08228
    Location:42309
    STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6
  6. NM_001166171.2NP_001159643.1  serine/threonine-protein kinase Nek6 isoform 1

    See identical proteins and their annotated locations for NP_001159643.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Both variants 1 and 7 encode the same protein.
    Source sequence(s)
    AL137846, AL162724, BC012761, DB350175
    Consensus CDS
    CCDS48015.1
    UniProtKB/Swiss-Prot
    Q9HC98
    Related
    ENSP00000377749.2, ENST00000394199.6
    Conserved Domains (2) summary
    smart00220
    Location:79344
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08228
    Location:76343
    STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6
  7. NM_014397.6NP_055212.2  serine/threonine-protein kinase Nek6 isoform 2

    See identical proteins and their annotated locations for NP_055212.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 5 and 6 encode the same isoform (2).
    Source sequence(s)
    AF087909, AL137846, BC012761, CF994196
    Consensus CDS
    CCDS6854.1
    UniProtKB/Swiss-Prot
    B7Z2D9, Q5TBG3, Q5TBG9, Q6FG86, Q6IAR3, Q96E83, Q9HC98, Q9ULX2
    Related
    ENSP00000319734.5, ENST00000320246.10
    Conserved Domains (1) summary
    cd08228
    Location:42309
    STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    124257606..124353307
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422652.1XP_047278608.1  serine/threonine-protein kinase Nek6 isoform X2

  2. XM_024447387.2XP_024303155.1  serine/threonine-protein kinase Nek6 isoform X4

    UniProtKB/Swiss-Prot
    B7Z2D9, Q5TBG3, Q5TBG9, Q6FG86, Q6IAR3, Q96E83, Q9HC98, Q9ULX2
    Conserved Domains (1) summary
    cd08228
    Location:42309
    STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6
  3. XM_047422653.1XP_047278609.1  serine/threonine-protein kinase Nek6 isoform X3

  4. XM_017014217.2XP_016869706.1  serine/threonine-protein kinase Nek6 isoform X2

    UniProtKB/Swiss-Prot
    Q9HC98
    Conserved Domains (2) summary
    smart00220
    Location:79344
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08228
    Location:76343
    STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6
  5. XM_047422651.1XP_047278607.1  serine/threonine-protein kinase Nek6 isoform X1

  6. XM_047422654.1XP_047278610.1  serine/threonine-protein kinase Nek6 isoform X2

RNA

  1. XR_007061235.1 RNA Sequence

  2. XR_007061234.1 RNA Sequence

  3. XR_007061237.1 RNA Sequence

  4. XR_007061236.1 RNA Sequence

  5. XR_007061238.1 RNA Sequence

  6. XR_007061233.1 RNA Sequence

  7. XR_007061232.1 RNA Sequence

  8. XR_007061231.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    136455708..136551354
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361796.1XP_054217771.1  serine/threonine-protein kinase Nek6 isoform X4

    UniProtKB/Swiss-Prot
    B7Z2D9, Q5TBG3, Q5TBG9, Q6FG86, Q6IAR3, Q96E83, Q9HC98, Q9ULX2
  2. XM_054361797.1XP_054217772.1  serine/threonine-protein kinase Nek6 isoform X4

    UniProtKB/Swiss-Prot
    B7Z2D9, Q5TBG3, Q5TBG9, Q6FG86, Q6IAR3, Q96E83, Q9HC98, Q9ULX2
  3. XM_054361798.1XP_054217773.1  serine/threonine-protein kinase Nek6 isoform X4

    UniProtKB/Swiss-Prot
    B7Z2D9, Q5TBG3, Q5TBG9, Q6FG86, Q6IAR3, Q96E83, Q9HC98, Q9ULX2
  4. XM_054361794.1XP_054217769.1  serine/threonine-protein kinase Nek6 isoform X3

  5. XM_054361800.1XP_054217775.1  serine/threonine-protein kinase Nek6 isoform X4

    UniProtKB/Swiss-Prot
    B7Z2D9, Q5TBG3, Q5TBG9, Q6FG86, Q6IAR3, Q96E83, Q9HC98, Q9ULX2
  6. XM_054361793.1XP_054217768.1  serine/threonine-protein kinase Nek6 isoform X2

  7. XM_054361792.1XP_054217767.1  serine/threonine-protein kinase Nek6 isoform X1

  8. XM_054361799.1XP_054217774.1  serine/threonine-protein kinase Nek6 isoform X4

    UniProtKB/Swiss-Prot
    B7Z2D9, Q5TBG3, Q5TBG9, Q6FG86, Q6IAR3, Q96E83, Q9HC98, Q9ULX2
  9. XM_054361795.1XP_054217770.1  serine/threonine-protein kinase Nek6 isoform X2