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NEK6 NIMA related kinase 6 [ Homo sapiens (human) ]

Gene ID: 10783, updated on 21-Dec-2019

Summary

Official Symbol
NEK6provided by HGNC
Official Full Name
NIMA related kinase 6provided by HGNC
Primary source
HGNC:HGNC:7749
See related
Ensembl:ENSG00000119408 MIM:604884
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SID6-1512
Summary
The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in placenta (RPKM 13.1), appendix (RPKM 13.0) and 25 other tissues See more
Orthologs

Genomic context

See NEK6 in Genome Data Viewer
Location:
9q33.3
Exon count:
17
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (124257606..124352442)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (127019885..127114721)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987037 Neighboring gene NFE2L2 motif-containing MPRA enhancer 159 Neighboring gene uncharacterized LOC613206 Neighboring gene uncharacterized LOC105376269 Neighboring gene uncharacterized LOC100129034 Neighboring gene proteasome 20S subunit beta 7 Neighboring gene uncharacterized LOC105376270 Neighboring gene adhesion G protein-coupled receptor D2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
activating transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
kinesin binding IPI
Inferred from Physical Interaction
more info
PubMed 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
transcription corepressor binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
chromosome segregation IDA
Inferred from Direct Assay
more info
PubMed 
mitotic nuclear envelope disassembly TAS
Traceable Author Statement
more info
 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling HMP PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cellular senescence TAS
Traceable Author Statement
more info
PubMed 
regulation of mitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
regulation of mitotic metaphase/anaphase transition IDA
Inferred from Direct Assay
more info
PubMed 
spindle assembly TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
centriolar satellite IDA
Inferred from Direct Assay
more info
 
colocalizes_with centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
spindle pole IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase Nek6
Names
NIMA (never in mitosis gene a)-related kinase 6
never in mitosis A-related kinase 6
nimA-related protein kinase 6
protein kinase SID6-1512
putative serine-threonine protein kinase
NP_001138473.1
NP_001159639.1
NP_001159640.1
NP_001159641.1
NP_001159642.1
NP_001159643.1
NP_055212.2
XP_005251721.1
XP_006716999.1
XP_016869706.1
XP_024303153.1
XP_024303154.1
XP_024303155.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145001.2NP_001138473.1  serine/threonine-protein kinase Nek6 isoform 1

    See identical proteins and their annotated locations for NP_001138473.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 7 encode the same isoform (1).
    Source sequence(s)
    AF087909, AL137846, BC004174, BC012761, CF994196
    Consensus CDS
    CCDS48015.1
    UniProtKB/Swiss-Prot
    Q9HC98
    Related
    ENSP00000362702.3, ENST00000373600.7
    Conserved Domains (2) summary
    smart00220
    Location:79344
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08228
    Location:76343
    STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6
  2. NM_001166167.1NP_001159639.1  serine/threonine-protein kinase Nek6 isoform 3

    See identical proteins and their annotated locations for NP_001159639.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AF087909, AL137846, BC012761, BM083872
    Consensus CDS
    CCDS55338.1
    UniProtKB/Swiss-Prot
    Q9HC98
    Related
    ENSP00000441469.1, ENST00000540326.5
    Conserved Domains (2) summary
    smart00220
    Location:63328
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08228
    Location:60327
    STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6
  3. NM_001166168.1NP_001159640.1  serine/threonine-protein kinase Nek6 isoform 2

    See identical proteins and their annotated locations for NP_001159640.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 5 and 6 encode the same isoform (2).
    Source sequence(s)
    AF087909, AL137846, BC012761, BP279761
    Consensus CDS
    CCDS6854.1
    UniProtKB/Swiss-Prot
    Q9HC98
    UniProtKB/TrEMBL
    A0A024R8A6
    Related
    ENSP00000442636.1, ENST00000545174.5
    Conserved Domains (1) summary
    cd08228
    Location:42309
    STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6
  4. NM_001166169.1NP_001159641.1  serine/threonine-protein kinase Nek6 isoform 4

    See identical proteins and their annotated locations for NP_001159641.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK294614, AL137846, AL162724, BC012761
    Consensus CDS
    CCDS55339.1
    UniProtKB/Swiss-Prot
    Q9HC98
    Related
    ENSP00000439651.1, ENST00000539416.5
    Conserved Domains (2) summary
    smart00220
    Location:70335
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08228
    Location:67334
    STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6
  5. NM_001166170.1NP_001159642.1  serine/threonine-protein kinase Nek6 isoform 2

    See identical proteins and their annotated locations for NP_001159642.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 5 and 6 encode the same isoform (2).
    Source sequence(s)
    AL137846, AL162724, BC012761
    Consensus CDS
    CCDS6854.1
    UniProtKB/Swiss-Prot
    Q9HC98
    UniProtKB/TrEMBL
    A0A024R8A6
    Related
    ENSP00000441426.1, ENST00000546191.5
    Conserved Domains (1) summary
    cd08228
    Location:42309
    STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6
  6. NM_001166171.1NP_001159643.1  serine/threonine-protein kinase Nek6 isoform 1

    See identical proteins and their annotated locations for NP_001159643.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Both variants 1 and 7 encode the same protein.
    Source sequence(s)
    AL137846, AL162724, BC012761, DB350175
    Consensus CDS
    CCDS48015.1
    UniProtKB/Swiss-Prot
    Q9HC98
    Related
    ENSP00000377749.2, ENST00000394199.6
    Conserved Domains (2) summary
    smart00220
    Location:79344
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08228
    Location:76343
    STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6
  7. NM_014397.5NP_055212.2  serine/threonine-protein kinase Nek6 isoform 2

    See identical proteins and their annotated locations for NP_055212.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 5 and 6 encode the same isoform (2).
    Source sequence(s)
    AF087909, AL137846, BC012761, CF994196
    Consensus CDS
    CCDS6854.1
    UniProtKB/Swiss-Prot
    Q9HC98
    UniProtKB/TrEMBL
    A0A024R8A6
    Related
    ENSP00000319734.5, ENST00000320246.9
    Conserved Domains (1) summary
    cd08228
    Location:42309
    STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    124257606..124352442
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447387.1XP_024303155.1  serine/threonine-protein kinase Nek6 isoform X3

    Conserved Domains (1) summary
    cd08228
    Location:42309
    STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6
  2. XM_005251664.1XP_005251721.1  serine/threonine-protein kinase Nek6 isoform X3

    See identical proteins and their annotated locations for XP_005251721.1

    UniProtKB/Swiss-Prot
    Q9HC98
    UniProtKB/TrEMBL
    A0A024R8A6
    Conserved Domains (1) summary
    cd08228
    Location:42309
    STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6
  3. XM_024447386.1XP_024303154.1  serine/threonine-protein kinase Nek6 isoform X3

    Conserved Domains (1) summary
    cd08228
    Location:42309
    STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6
  4. XM_006716936.2XP_006716999.1  serine/threonine-protein kinase Nek6 isoform X3

    See identical proteins and their annotated locations for XP_006716999.1

    UniProtKB/Swiss-Prot
    Q9HC98
    UniProtKB/TrEMBL
    A0A024R8A6
    Conserved Domains (1) summary
    cd08228
    Location:42309
    STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6
  5. XM_017014217.1XP_016869706.1  serine/threonine-protein kinase Nek6 isoform X2

    UniProtKB/Swiss-Prot
    Q9HC98
    Conserved Domains (2) summary
    smart00220
    Location:79344
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08228
    Location:76343
    STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6
  6. XM_024447385.1XP_024303153.1  serine/threonine-protein kinase Nek6 isoform X1

    Conserved Domains (1) summary
    cd08228
    Location:100367
    STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6
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