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ZNF234 zinc finger protein 234 [ Homo sapiens (human) ]

Gene ID: 10780, updated on 12-Oct-2019

Summary

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Official Symbol
ZNF234provided by HGNC
Official Full Name
zinc finger protein 234provided by HGNC
Primary source
HGNC:HGNC:13027
See related
Ensembl:ENSG00000263002 MIM:604750
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HZF4; ZNF269
Expression
Ubiquitous expression in spleen (RPKM 2.1), thyroid (RPKM 2.0) and 25 other tissues See more
Orthologs
all

Genomic context

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See ZNF234 in Genome Data Viewer
Location:
19q13.31
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (44141530..44160313)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44645710..44664462)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100379224 Neighboring gene zinc finger protein 224 Neighboring gene zinc finger protein 225 Neighboring gene zinc finger protein 226 Neighboring gene zinc finger protein 227

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937. Abrink M, et al. DNA Cell Biol, 1995 Feb. PMID 7865130
  2. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. Shannon M, et al. Genome Res, 2003 Jun. PMID 12743021, Free PMC Article
  3. Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. Wang J, et al. J Proteome Res, 2008 Sep. PMID 18624398
  4. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. Bett JS, et al. Biochem J, 2013 Apr 15. PMID 23398456, Free PMC Article
  5. SR protein kinases promote splicing of nonconsensus introns. Lipp JJ, et al. Nat Struct Mol Biol, 2015 Aug. PMID 26167880

See all (10) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from BioSystems

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  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
  
metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 234
Names
C2-H2 type zinc finger protein
Homo sapiens zinc finger 234
zinc finger protein 234, partial sequence
zinc finger protein 269
zinc finger protein 4
zinc finger protein HZF4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144824.2 → NP_001138296.1  zinc finger protein 234

    See identical proteins and their annotated locations for NP_001138296.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC021092, AC138470, AK314064
    Consensus CDS
    CCDS46101.1
    UniProtKB/Swiss-Prot
    Q14588
    UniProtKB/TrEMBL
    A0A024R0N3
    Related
    ENSP00000465011.1, ENST00000592437.5
    Conserved Domains (6) summary
    smart00349
    Location:8 → 65
    KRAB; krueppel associated box
    COG5048
    Location:258 → 672
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:486 → 506
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:204 → 226
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:639 → 662
    zf-H2C2_2; Zinc-finger double domain

  2. NM_006630.3 → NP_006621.1  zinc finger protein 234

    See identical proteins and their annotated locations for NP_006621.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC021092, AC138470, AK289843, AK314064
    Consensus CDS
    CCDS46101.1
    UniProtKB/Swiss-Prot
    Q14588
    UniProtKB/TrEMBL
    A0A024R0N3
    Related
    ENSP00000400878.1, ENST00000426739.7
    Conserved Domains (6) summary
    smart00349
    Location:8 → 65
    KRAB; krueppel associated box
    COG5048
    Location:258 → 672
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:486 → 506
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:204 → 226
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:639 → 662
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    44141530..44160313
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026152.1 → XP_016881641.1  zinc finger protein 234 isoform X4

  2. XM_017026153.1 → XP_016881642.1  zinc finger protein 234 isoform X4

  3. XM_017026149.1 → XP_016881638.1  zinc finger protein 234 isoform X1

    UniProtKB/Swiss-Prot
    Q14588
    UniProtKB/TrEMBL
    A0A024R0N3
    Conserved Domains (6) summary
    smart00349
    Location:8 → 65
    KRAB; krueppel associated box
    COG5048
    Location:258 → 672
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:486 → 506
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:204 → 226
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:639 → 662
    zf-H2C2_2; Zinc-finger double domain

  4. XM_017026151.1 → XP_016881640.1  zinc finger protein 234 isoform X3

  5. XM_017026150.1 → XP_016881639.1  zinc finger protein 234 isoform X2

    Conserved Domains (6) summary
    smart00349
    Location:8 → 63
    KRAB; krueppel associated box
    COG5048
    Location:246 → 660
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:474 → 494
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:192 → 214
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:627 → 650
    zf-H2C2_2; Zinc-finger double domain

  6. XM_006722974.3 → XP_006723037.1  zinc finger protein 234 isoform X1

    See identical proteins and their annotated locations for XP_006723037.1

    UniProtKB/Swiss-Prot
    Q14588
    UniProtKB/TrEMBL
    A0A024R0N3
    Conserved Domains (6) summary
    smart00349
    Location:8 → 65
    KRAB; krueppel associated box
    COG5048
    Location:258 → 672
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:486 → 506
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:204 → 226
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:639 → 662
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14588.3 GenPept UniProtKB/Swiss-Prot:Q14588

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