U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZNF234 zinc finger protein 234 [ Homo sapiens (human) ]

Gene ID: 10780, updated on 11-Jun-2025
Official Symbol
ZNF234provided by HGNC
Official Full Name
zinc finger protein 234provided by HGNC
Primary source
HGNC:HGNC:13027
See related
Ensembl:ENSG00000263002 MIM:604750; AllianceGenome:HGNC:13027
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HZF4; ZNF269
Summary
Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jun 2025]
Expression
Ubiquitous expression in spleen (RPKM 2.1), thyroid (RPKM 2.0) and 25 other tissues See more
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table
See ZNF234 in Genome Data Viewer
Location:
19q13.31
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (44141554..44160313)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (46964407..46983173)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44645707..44664466)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 224 Neighboring gene ZNF225 and ZNF224 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:44617263-44617613 Neighboring gene zinc finger protein 225 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:44645889-44646479 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14756 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14757 Neighboring gene zinc finger protein 226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14758 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14759 Neighboring gene zinc finger protein 227 Neighboring gene uncharacterized LOC124904726

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937. Abrink M, et al. DNA Cell Biol, 1995 Feb. PMID 7865130
  2. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. Shannon M, et al. Genome Res, 2003 Jun. PMID 12743021, Free PMC Article
  3. A GO catalogue of human DNA-binding transcription factors. Lovering RC, et al. Biochim Biophys Acta Gene Regul Mech, 2021 Nov-Dec. PMID 34673265
  4. Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. Wang J, et al. J Proteome Res, 2008 Sep. PMID 18624398
  5. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. Bett JS, et al. Biochem J, 2013 Apr 15. PMID 23398456, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
zinc finger protein 234
Names
C2-H2 type zinc finger protein
Homo sapiens zinc finger 234
zinc finger protein 234, partial sequence
zinc finger protein 269
zinc finger protein 4
zinc finger protein HZF4

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144824.2 → NP_001138296.1  zinc finger protein 234

    See identical proteins and their annotated locations for NP_001138296.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC021092, AC138470, AK314064
    Consensus CDS
    CCDS46101.1
    UniProtKB/Swiss-Prot
    A8K1C8, Q14588, Q96IR4, Q9NS45, Q9NYT7
    Related
    ENSP00000465011.1, ENST00000592437.5
    Conserved Domains (6) summary
    smart00349
    Location:8 → 65
    KRAB; krueppel associated box
    COG5048
    Location:258 → 672
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:486 → 506
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:204 → 226
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:639 → 662
    zf-H2C2_2; Zinc-finger double domain

  2. NM_006630.3 → NP_006621.1  zinc finger protein 234

    See identical proteins and their annotated locations for NP_006621.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC021092, AC138470, AK289843, AK314064
    Consensus CDS
    CCDS46101.1
    UniProtKB/Swiss-Prot
    A8K1C8, Q14588, Q96IR4, Q9NS45, Q9NYT7
    Related
    ENSP00000400878.1, ENST00000426739.7
    Conserved Domains (6) summary
    smart00349
    Location:8 → 65
    KRAB; krueppel associated box
    COG5048
    Location:258 → 672
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:486 → 506
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:204 → 226
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:639 → 662
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    44141554..44160313
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438061.1 → XP_047294017.1  zinc finger protein 234 isoform X2

  2. XM_006722974.4 → XP_006723037.1  zinc finger protein 234 isoform X1

    See identical proteins and their annotated locations for XP_006723037.1

    UniProtKB/Swiss-Prot
    A8K1C8, Q14588, Q96IR4, Q9NS45, Q9NYT7
    Conserved Domains (6) summary
    smart00349
    Location:8 → 65
    KRAB; krueppel associated box
    COG5048
    Location:258 → 672
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:486 → 506
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:204 → 226
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:639 → 662
    zf-H2C2_2; Zinc-finger double domain

  3. XM_047438063.1 → XP_047294019.1  zinc finger protein 234 isoform X3

  4. XM_017026149.2 → XP_016881638.1  zinc finger protein 234 isoform X1

    UniProtKB/Swiss-Prot
    A8K1C8, Q14588, Q96IR4, Q9NS45, Q9NYT7
    Conserved Domains (6) summary
    smart00349
    Location:8 → 65
    KRAB; krueppel associated box
    COG5048
    Location:258 → 672
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:486 → 506
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:204 → 226
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:639 → 662
    zf-H2C2_2; Zinc-finger double domain

  5. XM_017026150.2 → XP_016881639.1  zinc finger protein 234 isoform X2

    Conserved Domains (6) summary
    smart00349
    Location:8 → 63
    KRAB; krueppel associated box
    COG5048
    Location:246 → 660
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:474 → 494
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:192 → 214
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:627 → 650
    zf-H2C2_2; Zinc-finger double domain

  6. XM_017026151.2 → XP_016881640.1  zinc finger protein 234 isoform X3

  7. XM_047438060.1 → XP_047294016.1  zinc finger protein 234 isoform X2

  8. XM_047438062.1 → XP_047294018.1  zinc finger protein 234 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    46964407..46983173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319544.1 → XP_054175519.1  zinc finger protein 234 isoform X1

  2. XM_054319547.1 → XP_054175522.1  zinc finger protein 234 isoform X2

  3. XM_054319549.1 → XP_054175524.1  zinc finger protein 234 isoform X3

  4. XM_054319546.1 → XP_054175521.1  zinc finger protein 234 isoform X2

  5. XM_054319548.1 → XP_054175523.1  zinc finger protein 234 isoform X3

  6. XM_054319545.1 → XP_054175520.1  zinc finger protein 234 isoform X1

  7. XM_054319550.1 → XP_054175525.1  zinc finger protein 234 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14588.3 GenPept UniProtKB/Swiss-Prot:Q14588

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous