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ZNF234 zinc finger protein 234 [ Homo sapiens (human) ]

Gene ID: 10780, updated on 11-Jun-2025
Official Symbol
ZNF234provided by HGNC
Official Full Name
zinc finger protein 234provided by HGNC
Primary source
HGNC:HGNC:13027
See related
Ensembl:ENSG00000263002 MIM:604750; AllianceGenome:HGNC:13027
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HZF4; ZNF269
Summary
Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jun 2025]
Expression
Ubiquitous expression in spleen (RPKM 2.1), thyroid (RPKM 2.0) and 25 other tissues See more
Orthologs
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See ZNF234 in Genome Data Viewer
Location:
19q13.31
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (44141554..44160313)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (46964407..46983173)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44645707..44664466)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 224 Neighboring gene ZNF225 and ZNF224 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:44617263-44617613 Neighboring gene zinc finger protein 225 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:44645889-44646479 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14756 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14757 Neighboring gene zinc finger protein 226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14758 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14759 Neighboring gene zinc finger protein 227 Neighboring gene uncharacterized LOC124904726

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
zinc finger protein 234
Names
C2-H2 type zinc finger protein
Homo sapiens zinc finger 234
zinc finger protein 234, partial sequence
zinc finger protein 269
zinc finger protein 4
zinc finger protein HZF4

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144824.2NP_001138296.1  zinc finger protein 234

    See identical proteins and their annotated locations for NP_001138296.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC021092, AC138470, AK314064
    Consensus CDS
    CCDS46101.1
    UniProtKB/Swiss-Prot
    A8K1C8, Q14588, Q96IR4, Q9NS45, Q9NYT7
    Related
    ENSP00000465011.1, ENST00000592437.5
    Conserved Domains (6) summary
    smart00349
    Location:865
    KRAB; krueppel associated box
    COG5048
    Location:258672
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:486506
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:204226
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:639662
    zf-H2C2_2; Zinc-finger double domain
  2. NM_006630.3NP_006621.1  zinc finger protein 234

    See identical proteins and their annotated locations for NP_006621.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC021092, AC138470, AK289843, AK314064
    Consensus CDS
    CCDS46101.1
    UniProtKB/Swiss-Prot
    A8K1C8, Q14588, Q96IR4, Q9NS45, Q9NYT7
    Related
    ENSP00000400878.1, ENST00000426739.7
    Conserved Domains (6) summary
    smart00349
    Location:865
    KRAB; krueppel associated box
    COG5048
    Location:258672
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:486506
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:204226
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:639662
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    44141554..44160313
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438061.1XP_047294017.1  zinc finger protein 234 isoform X2

  2. XM_006722974.4XP_006723037.1  zinc finger protein 234 isoform X1

    See identical proteins and their annotated locations for XP_006723037.1

    UniProtKB/Swiss-Prot
    A8K1C8, Q14588, Q96IR4, Q9NS45, Q9NYT7
    Conserved Domains (6) summary
    smart00349
    Location:865
    KRAB; krueppel associated box
    COG5048
    Location:258672
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:486506
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:204226
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:639662
    zf-H2C2_2; Zinc-finger double domain
  3. XM_047438063.1XP_047294019.1  zinc finger protein 234 isoform X3

  4. XM_017026149.2XP_016881638.1  zinc finger protein 234 isoform X1

    UniProtKB/Swiss-Prot
    A8K1C8, Q14588, Q96IR4, Q9NS45, Q9NYT7
    Conserved Domains (6) summary
    smart00349
    Location:865
    KRAB; krueppel associated box
    COG5048
    Location:258672
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:486506
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:204226
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:639662
    zf-H2C2_2; Zinc-finger double domain
  5. XM_017026150.2XP_016881639.1  zinc finger protein 234 isoform X2

    Conserved Domains (6) summary
    smart00349
    Location:863
    KRAB; krueppel associated box
    COG5048
    Location:246660
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:474494
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:192214
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:627650
    zf-H2C2_2; Zinc-finger double domain
  6. XM_017026151.2XP_016881640.1  zinc finger protein 234 isoform X3

  7. XM_047438060.1XP_047294016.1  zinc finger protein 234 isoform X2

  8. XM_047438062.1XP_047294018.1  zinc finger protein 234 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    46964407..46983173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319544.1XP_054175519.1  zinc finger protein 234 isoform X1

  2. XM_054319547.1XP_054175522.1  zinc finger protein 234 isoform X2

  3. XM_054319549.1XP_054175524.1  zinc finger protein 234 isoform X3

  4. XM_054319546.1XP_054175521.1  zinc finger protein 234 isoform X2

  5. XM_054319548.1XP_054175523.1  zinc finger protein 234 isoform X3

  6. XM_054319545.1XP_054175520.1  zinc finger protein 234 isoform X1

  7. XM_054319550.1XP_054175525.1  zinc finger protein 234 isoform X3