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Mylk myosin, light polypeptide kinase [ Mus musculus (house mouse) ]

Gene ID: 107589, updated on 12-Feb-2024

Summary

Official Symbol
Mylkprovided by MGI
Official Full Name
myosin, light polypeptide kinaseprovided by MGI
Primary source
MGI:MGI:894806
See related
Ensembl:ENSMUSG00000022836 AllianceGenome:MGI:894806
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KRP; Mlck; nmMlck; smMLCK; MLCK108; MLCK210; 9530072E15Rik; A930019C19Rik
Summary
Enables enzyme binding activity. Involved in tonic smooth muscle contraction. Acts upstream of or within cellular response to calcium ion; cellular response to potassium ion; and cellular response to xenobiotic stimulus. Located in cell-cell junction. Is expressed in several structures, including central nervous system; heart; liver; and retina. Human ortholog(s) of this gene implicated in adult respiratory distress syndrome; asthma; and thoracic aortic aneurysm. Orthologous to human MYLK (myosin light chain kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 454.5), large intestine adult (RPKM 64.4) and 8 other tissues See more
Orthologs
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Genomic context

See Mylk in Genome Data Viewer
Location:
16 B3; 16 24.49 cM
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (34565569..34822806)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (34745199..35002436)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40725 Neighboring gene STARR-positive B cell enhancer ABC_E5539 Neighboring gene ropporin, rhophilin associated protein 1 Neighboring gene predicted gene, 35150 Neighboring gene coiled-coil domain containing 14 Neighboring gene STARR-seq mESC enhancer starr_40726 Neighboring gene RIKEN cDNA 1700119H24 gene Neighboring gene STARR-seq mESC enhancer starr_40727 Neighboring gene RIKEN cDNA E130310I04 gene Neighboring gene predicted gene, 53951 Neighboring gene STARR-seq mESC enhancer starr_40730 Neighboring gene STARR-seq mESC enhancer starr_40731 Neighboring gene STARR-positive B cell enhancer ABC_E1922 Neighboring gene predicted gene, 21691 Neighboring gene predicted gene, 53952 Neighboring gene 3-hydroxyacyl-CoA dehydratase 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables myosin light chain kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables myosin light chain kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cleavage furrow IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cleavage furrow ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
myosin light chain kinase, smooth muscle
Names
kinase-related protein
telokin
NP_001395190.1
NP_001395191.1
NP_001395192.1
NP_647461.3
XP_006521765.1
XP_006521768.1
XP_017172338.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001408261.1NP_001395190.1  myosin light chain kinase, smooth muscle isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC110166, AC154813
    UniProtKB/Swiss-Prot
    Q3TSJ7, Q6PDN3, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3
  2. NM_001408262.1NP_001395191.1  myosin light chain kinase, smooth muscle isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC110166, AC154813
  3. NM_001408263.1NP_001395192.1  myosin light chain kinase, smooth muscle isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC110166, AC154813
  4. NM_139300.4NP_647461.3  myosin light chain kinase, smooth muscle isoform 2

    See identical proteins and their annotated locations for NP_647461.3

    Status: VALIDATED

    Source sequence(s)
    AC110166, AC154813, CT010574
    Consensus CDS
    CCDS37320.1
    UniProtKB/Swiss-Prot
    Q3TSJ7, Q6PDN3, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3
    UniProtKB/TrEMBL
    B1B1A8
    Related
    ENSMUSP00000023538.9, ENSMUST00000023538.9
    Conserved Domains (8) summary
    cd00096
    Location:637706
    Ig; Immunoglobulin domain
    smart00408
    Location:524587
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:13621453
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:18401930
    I-set; Immunoglobulin I-set domain
    cd14191
    Location:14921750
    STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
    pfam00069
    Location:14951750
    Pkinase; Protein kinase domain
    pfam16620
    Location:255409
    23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
    cl11960
    Location:12691366
    Ig; Immunoglobulin domain

RNA

  1. NR_176622.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC110166, AC154813

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    34565569..34822806
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521702.1XP_006521765.1  myosin light chain kinase, smooth muscle isoform X1

    See identical proteins and their annotated locations for XP_006521765.1

    UniProtKB/Swiss-Prot
    Q3TSJ7, Q6PDN3, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3
    Conserved Domains (5) summary
    cd00063
    Location:13531444
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14191
    Location:14831741
    STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
    pfam07679
    Location:18311921
    I-set; Immunoglobulin I-set domain
    pfam16620
    Location:246400
    23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
    cl11960
    Location:12601357
    Ig; Immunoglobulin domain
  2. XM_017316849.2XP_017172338.1  myosin light chain kinase, smooth muscle isoform X2

    UniProtKB/Swiss-Prot
    Q3TSJ7, Q6PDN3, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3
    Conserved Domains (5) summary
    cd00063
    Location:13071398
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14191
    Location:14371695
    STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
    pfam07679
    Location:17851875
    I-set; Immunoglobulin I-set domain
    pfam16620
    Location:246400
    23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
    cl11960
    Location:12141311
    Ig; Immunoglobulin domain
  3. XM_006521705.3XP_006521768.1  myosin light chain kinase, smooth muscle isoform X3

    Conserved Domains (4) summary
    cd05762
    Location:38135
    Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains
    cd00063
    Location:131222
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:609699
    I-set; Immunoglobulin I-set domain
    cl21453
    Location:261519
    PKc_like; Protein Kinases, catalytic domain